Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications: Proceedings of the 6th International Conference on Sodium Calcium Exchange

Front Matter....Pages i-xxv
Front Matter....Pages 1-1
Livin’ with NCX and Lovin’ It: A 45 Year Romance....Pages 3-15
20 Years from NCX Purification and Cloning: Milestones....Pages 17-23
Front Matter....Pages 25-25
Ca 2+ Regulation in the Na + /Ca 2+ Exchanger Features a Dual Electrostatic Switch Mechanism....Pages 27-33
Molecular Determinants of Allosteric Regulation in NCX Proteins....Pages 35-48
NCX1: Mechanism of Transport....Pages 49-54
Structural Studies of the Ca 2+ Regulatory Domain of Drosophila Na + /Ca 2+ Exchanger CALX....Pages 55-63
Interplay of Ca 2+ and Mg 2+ in Sodium-Calcium Exchanger and in Other Ca 2+ -Binding Proteins: Magnesium, Watchdog That Blocks Each Turn if Able....Pages 65-78
Front Matter....Pages 79-79
Functional and Structural Properties of the NCKX2 Na + -Ca 2+ /K + Exchanger: A Comparison with the NCX1 Na + /Ca 2+ Exchanger....Pages 81-94
NCKX5, a Natural Regulator of Human Skin Colour Variation, Regulates the Expression of Key Pigment Genes MC1R and Alpha-MSH and Alters Cholesterol Homeostasis in Normal Human Melanocytes....Pages 95-107
Expression and Regulation of Sodium/Calcium Exchangers, NCX and NCKX, in Reproductive Tissues: Do They Play a Critical Role in Calcium Transport for Reproduction and Development?....Pages 109-121
Front Matter....Pages 123-123
Transcriptional Pathways and Potential Therapeutic Targets in the Regulation of Ncx1 Expression in Cardiac Hypertrophy and Failure....Pages 125-135
Transcriptional Regulation of ncx1 Gene in the Brain....Pages 137-145
Front Matter....Pages 147-147
Metabolic Regulation of the Squid Nerve Na + /Ca 2+ Exchanger: Recent Developments....Pages 149-161
Regulation of Sodium-Calcium Exchanger Activity by Creatine Kinase....Pages 163-173
Coordinated Regulation of Cardiac Na + /Ca 2+ Exchanger and Na + -K + -ATPase by Phospholemman (FXYD1)....Pages 175-190
Front Matter....Pages 191-191
Mitochondria Na + -Ca 2+ Exchange in Cardiomyocytes and Lymphocytes....Pages 193-201
New Insights in Mitochondrial Calcium Handling by Sodium/Calcium Exchanger....Pages 203-209
Front Matter....Pages 211-211
Genetically Modified Mice as a Strategy to Unravel the Role Played by the Na + /Ca 2+ Exchanger in Brain Ischemia and in Spatial Learning and Memory Deficits....Pages 213-222
NCX as a Key Player in the Neuroprotection Exerted by Ischemic Preconditioning and Postconditioning....Pages 223-240
The Role of the Mitochondrial NCX in the Mechanism of Neurodegeneration in Parkinson’s Disease....Pages 241-249
Front Matter....Pages 211-211
The Contribution of the Sodium-Calcium Exchanger (NCX) and Plasma Membrane Ca 2+ ATPase (PMCA) to Cerebellar Synapse Function....Pages 251-263
Front Matter....Pages 265-265
Sodium-Calcium Exchanger Modulates the L-Glutamate Ca i 2+ Signalling in Type-1 Cerebellar Astrocytes....Pages 267-274
Immunosuppressive Drugs, Immunophilins, and Functional Expression of NCX Isoforms....Pages 275-287
Calcium Influx Through Reversed NCX Controls Migration of Microglia....Pages 289-294
Sodium Fluxes and Astroglial Function....Pages 295-305
New Roles of NCX in Glial Cells: Activation of Microglia in Ischemia and Differentiation of Oligodendrocytes....Pages 307-316
Human Macrophages and Monocytes Express Functional Na + /Ca 2+ Exchangers 1 and 3....Pages 317-326
Front Matter....Pages 327-327
New Insights into the Contribution of Arterial NCX to the Regulation of Myogenic Tone and Blood Pressure....Pages 329-343
Toward an Understanding of the Complete NCX1 Lifetime in the Cardiac Sarcolemma....Pages 345-352
Front Matter....Pages 353-353
Cardiac Sodium-Calcium Exchange and Efficient Excitation-Contraction Coupling: Implications for Heart Disease....Pages 355-364
Cross Talk Between Plasma Membrane Na + /Ca 2+ Exchanger-1 and TRPC/Orai-Containing Channels: Key Players in Arterial Hypertension....Pages 365-374
T-Tubule Remodelling and Ryanodine Receptor Organization Modulate Sodium-Calcium Exchange....Pages 375-383
Na + /Ca 2+ Exchange and the Plasma Membrane Ca 2+ -ATPase in β-Cell Function and Diabetes....Pages 385-394
Front Matter....Pages 395-395
The Na + /H + Exchanger NHE5 Is Sorted to Discrete Intracellular Vesicles in the Central and Peripheral Nervous Systems....Pages 397-410
The Role of Na + /H + Exchanger Isoform 1 in Inflammatory Responses: Maintaining H + Homeostasis of Immune Cells....Pages 411-418
Acid-Sensing Ion Channels in Pathological Conditions....Pages 419-431
Nonselective Cation Channels and Links to Hippocampal Ischemia, Aging, and Dementia....Pages 433-447
Erratum To: Chapter 17 New Insights in Mitochondrial Calcium Handling by Sodium/Calcium Exchanger....Pages E1-E1
Back Matter....Pages 449-463