Small-Bowel Transplantation: Experimental and Clinical Fundamentals

Front Matter....Pages I-XV
Front Matter....Pages 1-1
Microsurgical Techniques of Heterotopic and Orthotopic Small-Bowel Transplantation in the Rat....Pages 2-6
Small-Bowel Transplantation in the Rat: Graft Survival with Heterotopic vs Orthotopic Position....Pages 7-13
Recent Results of Small-Bowel Transplantation in the Rat Model....Pages 14-18
Metabolic Effects of Systemic Venous Drainage in Small-Bowel Transplantation....Pages 19-23
Summary....Pages 24-24
Front Matter....Pages 25-25
Small-Bowel Transplantation in the Pig....Pages 26-33
Lymphatic Regeneration Following Intestinal Transplantation in the Pig....Pages 34-36
Serum Lactic Dehydrogenase in Small-Bowel Transplantation in the Pig....Pages 37-38
In Vitro and In Vivo Studies of the Mucosal Immune Barrier After Long-Term Small-Bowel Allotransplantation in Pigs Using Cyclosporine....Pages 39-43
Orthotopic Segmental Small-Intestinal Transplantation in the Dog....Pages 44-48
Duodenal Histology During Rejection of Whole-Organ Pancreaticoduodenal Allografts in the Pig....Pages 49-53
Segmental Small-Bowel Replacement by Gastric Tube in the Pig....Pages 54-57
Summary....Pages 58-58
Front Matter....Pages 59-59
Absorption and Graft Function After Small-Intestinal Transplantation....Pages 60-64
Intestinal Preservation of Small-Bowel Grafts by Vascular Washout and Cold Storage....Pages 65-73
Glucose Absorption After Heterotopic Small-Bowel Transplantation....Pages 74-78
Absorption Studies After Orthotopic Small-Bowel Transplantation....Pages 79-80
Functional Adaptation of the Small-Intestinal Mucosa After Experimental Small-Bowel Transplantation: A Quantitative Histochemical Study....Pages 81-83
Patterns of Gastrointestinal Hormone Distribution After Small-Bowel Transplantation....Pages 84-86
Summary....Pages 87-88
Front Matter....Pages 89-89
Early Intestinal Lesions of Graft-vs-Host Reaction and Allograft Rejection in Rodents, Identified by Quantitative Histological Techniques....Pages 90-94
Mucosal Mast Cells in Experimental Graft-vs-Host Reaction....Pages 95-97
Clinicopathologic Differentiation of Rejection and Graft-vs-Host Disease Following Small-Bowel Transplantation....Pages 98-108
Graft-vs-Host Reaction After Small-Bowel Transplantation Compared with Graft-vs-Host Reaction After Bone Marrow Transplantation....Pages 109-115
Rejection in Heterotopic Small-Bowel Transplantation....Pages 116-120
Rejection in Orthotopic Small-Bowel Transplantation and Immunosuppression by Cyclosporine A: Evidence for Development of Tolerance Mechanisms....Pages 121-124
Course of Rejection in Pancreaticoduodenal Allografts in the Rat....Pages 125-128
Prevention of Graft-vs-Host Disease Using in Vitro Irradiation of Small-Bowel Grafts....Pages 129-134
Graft Acceptance: Modification of Immunogenicity of the Donor or the Donor Organ with or without Host Immunosuppression....Pages 135-152
Summary....Pages 153-153
Front Matter....Pages 155-155
Long-Term Survival of Orthotopic Small-Bowel Allografts Using Cyclosporin A....Pages 156-160
Influence of Cyclosporine A on Small-Bowel Grafts and Subsequent in Vitro Immune Reactions....Pages 161-165
Different Modes of Cyclosporine A Administration in Experimental Small-Bowel Transplantation....Pages 166-169
Summary....Pages 170-170
Front Matter....Pages 171-171
Intestinal Transplantation: Surgical Techniques in Animals and Man....Pages 172-181
Stoma or No Stoma in Intestinal Transplantation....Pages 182-191
Small-Bowel Allotransplantation in Pigs Using Cyclosporine A: Technique and Results....Pages 192-195
Summary....Pages 196-196
Front Matter....Pages 197-197
Physical and Psychological Preparedness of Short-Bowel Patients for Small-Bowel Transplantation....Pages 198-202
Procurement of Intestinal Allografts from Living Related and from Cadaver Donors....Pages 203-210
Front Matter....Pages 197-197
Summary....Pages 211-211
Front Matter....Pages 213-213
Experience in Home Parenteral Nutrition and Indications for Small-Bowel Transplantation....Pages 214-221
Enteral and Parenteral Feeding of Patients with Short-Bowel Syndrome....Pages 222-224
Methods of Perioperative Nutritional Support and Their Possible Application in Small-Bowel Transplantation....Pages 225-229
Summary....Pages 230-231
Front Matter....Pages 233-233
Monitoring of Small-Bowel Grafts by Mucosal Suction Biopsies....Pages 234-240
Monitoring of Small-Bowel Allograft Rejection: Maltose Absorption....Pages 241-249
Porcine Ileal Peptide: A Potential Marker for Rejection of Small-Intestine Allografts....Pages 250-254
Summary....Pages 255-255
Front Matter....Pages 257-257
Potential Recipients for Small-Bowel Transplantation in the United States and the United Kingdom....Pages 258-261
Indications for Small-Bowel Transplantation in Children....Pages 262-264
Summary....Pages 265-267
Back Matter....Pages 268-272