Slow Virus Infections of the Central Nervous System: Investigational Approaches to Etiology and Pathogenesis of These Diseases

Front Matter....Pages i-xii
Front Matter....Pages 1-1
Scrapie: Pathogenesis in Inbred Mice: An Assessment of Host Control and Response Involving Many Strains of Agent....Pages 3-14
Kuru, Creutzfeldt-Jakob Disease, and Transmissible Presenile Dementias....Pages 15-49
Discussion/Chapters 1–2....Pages 50-51
Comment/Chapters 1–2....Pages 52-53
Sheep Progressive Pneumonia Viruses....Pages 54-66
Discussion/Chapter 3....Pages 67-67
Comment/Chapter 3....Pages 68-70
Comment/Chapter 3....Pages 71-72
Front Matter....Pages 73-73
Borna, the Disease—A Summary of Our Present Knowledge....Pages 75-83
Borna Disease: Patterns of Infection....Pages 84-88
Discussion/Chapters 4–5....Pages 89-90
Progressive Multifocal Leukoencephalopathy....Pages 91-100
Discussion/Chapter 6....Pages 101-102
Comment/Chapter 6....Pages 103-105
Subacute Sclerosing Panencephalitis....Pages 106-114
Comment/Chapter 7....Pages 115-115
A Concept of Virus-Induced Demyelinating Encephalomyelitis Relative to an Animal Model....Pages 116-126
Comment/Chapter 8....Pages 127-128
The Biologic Role of Host-Dependent Proteolytic Cleavage of a Paramyxovirus Glycoprotein....Pages 129-136
Discussion/Chapter 9....Pages 137-138
Front Matter....Pages 73-73
Comment/Chapter 9....Pages 139-139
Front Matter....Pages 141-141
Multiple Sclerosis: A Case for Viral Etiology....Pages 143-151
In Search of the Abominable Snowman or “deine Viren, meine Viren” in Multiple Sclerosis....Pages 152-158
Characterization of the Virus Antibody Activity of Oligoclonal IgG Produced in the Central Nervous System of Patients with Multiple Sclerosis....Pages 159-164
Discussion/Chapters 10–12....Pages 165-165
Demyelination in Experimental Allergic Encephalomyelitis and Multiple Sclerosis....Pages 166-185
Genetic Aspects of Multiple Sclerosis....Pages 186-199
Cell-Mediated Immunity in Multiple Sclerosis....Pages 200-206
Discussion/Chapters 13–15....Pages 207-208
Comment/Chapters 13–15....Pages 209-210
Front Matter....Pages 211-211
The Virologist....Pages 213-221
Temperature-Sensitive Viruses: Possible Role in Chronic and Inapparent Infections....Pages 222-227
Discussion/Chapters 16–17....Pages 228-228
The Geneticist....Pages 229-234
Discussion/Chapter 18....Pages 235-235
Critique: Afterthoughts of an Immunologist....Pages 236-240
Discussion/Chapter 19....Pages 241-241
Critique: The Epidemiologist....Pages 242-245
Discussion/Chapter 20....Pages 246-246
Comment/Chapter 20....Pages 247-248
Front Matter....Pages 211-211
Conclusions: Outlook on Future Research....Pages 249-253
Back Matter....Pages 255-258