Sliding Filament Mechanism in Muscle Contraction: Fifty Years of Research

Front Matter....Pages 1-1
Early Developments in Muscle Research and the Role of New Structural Technologies....Pages 3-11
The Molecular Basis of Cross-Bridge Function....Pages 13-23
Molecular Synchronization in Actomyosin Motors — From Single Molecule to Muscle Fiber Via Nanomuscle....Pages 25-36
Distribution of Crossbridge States in Contracting Muscle....Pages 37-44
X-Ray Diffraction Studies of Striated Muscles....Pages 45-60
Conformational Change and Regulation of Myosin Molecules....Pages 61-72
Front Matter....Pages 73-73
Driving Filament Sliding: Weak binding cross-bridge states, strong binding cross-bridge states, and the power stroke....Pages 75-91
Mysteries about Amplitude and Efficiency of Cross-Bridge Powerstroke....Pages 93-112
Sarcomere Dynamics, Stepwise Shortening and the Nature of Contraction....Pages 113-126
Crossbridge Formation Detected by Stiffness Measurements in Single Muscle Fibres....Pages 127-140
Non Cross-Bridge Stiffness in Skeletal Muscle Fibres at Rest and During Activity....Pages 141-155
Nature’s Strategy for Optimizing Power Generation in Insect Flight Muscle....Pages 157-167
Front Matter....Pages 169-169
From Crossbridges to Metabolism: System Biology for Energetics....Pages 171-182
Energetics, Mechanics and Molecular Engineering of Calcium Cycling in Skeletal Muscle....Pages 183-192
Heat, Phosphorus NMR and Microcalorimetry in Relation to the Mechanism of Filament Sliding....Pages 193-203
How Two-Foot Molecular Motors May Walk....Pages 205-219
Front Matter....Pages 221-221
Molecular Basis of Calcium Regulation of Striated Muscle Contraction....Pages 223-231
Mechanisms of Calcium Release from the Sarcoplasmic Reticulum in Skeletal Muscle....Pages 233-247
From Inward Spread of Activation, Active Elongation to the Effect of Organic Calcium Channel Blockers in Muscle Excitation-Contraction Coupling....Pages 249-265
Front Matter....Pages 267-267
Cardiac Myosin Binding Protein C: Modulator of Contractility....Pages 269-282
Front Matter....Pages 267-267
Human Atrial Myosin Light Chain 1 Expression Attenuates Heart Failure....Pages 283-292
Cytoplasmic Free Concentrations of Ca 2+ in Skeletal Muscle Cells....Pages 293-301
Mysterious Beauty of Beating Heart: Cardiac mechano-energetico-informatics....Pages 303-317
Is Myosin Phosphorylation Sufficient to Regulate Smooth Muscle Contraction?....Pages 319-328
Front Matter....Pages 329-329
Comparative Aspects of Crossbridge Function — Skinned Fibre Studies....Pages 331-340
Dynamic Structures of Myosin, Kinesin and Troponin as Detected by SDSL-ESR....Pages 341-348
Mutations of Transcription Factors in Human with Heart Disease for Understanding the Development and Mechanisms of Congenital Cardiovascular Heart Disease....Pages 349-357
General Discussion Part I Skeletal Muscle Mechanics....Pages 359-369
General Discussion Part II Skeletal Muscle Energetics....Pages 371-377
General Discussion — Skeletal Muscle III Structural Studies....Pages 379-395
General Discussion Part IV Cardiac Muscle....Pages 397-403
General Discussion Part V Smooth Muscle....Pages 405-415
Concluding Remarks....Pages 417-419