Side-Effects of Anti-Inflammatory Drugs: Part Two Studies in Major Organ Systems

Front Matter....Pages i-xxv
Front Matter....Pages 1-1
Mechanisms of gastric contrasted with intestinal damage by non-steroidal anti-inflammatory drugs....Pages 3-28
The enterohepatic circulation of some anti-inflammatory drugs may cause intestinal ulcerations....Pages 29-39
Limitations of laboratory models in predicting gastrointestinal toleration of oxicams and other anti-inflammatory drugs....Pages 41-54
Why are non-steroidal anti-inflammatory drugs so gastrotoxic, even when given orally as solubilized salt formulations or parenterally?....Pages 55-65
Early and late phases in the formation by anti-inflammatory drugs of intestinal lesions in rats....Pages 67-81
Role of intestinal microflora in maintaining indomethacin-induced intestinal lesions in rats....Pages 83-87
Comparison of gastric mucosal damage and prostaglandin formation in arthritis patients treated with carprofen and ibuprofen....Pages 89-96
Inhibition of prostanoid synthesis by anti-inflammatory drugs in human gastric mucosa....Pages 97-100
Leukotriene formation in the gastrointestinal tract and effects of anti-inflammatory drugs....Pages 101-112
Evidence for sulphydryl-sensitive process in the mechanisms of acute gastric mucosal injury and defence....Pages 113-121
Experimental and clinical studies on the prevention of aspirin-induced gastric damage by “cytoprotective” drugs....Pages 123-132
Both E Prostaglandins and prolonged indomethacin treatment exert trophic effects on the gastric mucosa....Pages 133-142
Gastrointestinal side-effects of prostaglandins....Pages 143-149
Investigation of auranofin-induced diarrhoea....Pages 151-158
Pyrido-pyrimidines — with analgesic and anti-inflammatory activity — inhibit the gastrointestinal mucosal damage induced by different prostaglandin synthesis inhibitors....Pages 159-160
Al(OH) 3 inhibits aspirin-induced gastric lesions in cats with Heidenhain pouch....Pages 161-162
Polyene phosphatidylcholine: an inhibitor of NSAID gastric toxicity which increases impaired mucosal PGE 2 synthesis....Pages 163-164
Prostaglandins prevent red streaks in rat gastric mucosa caused by intravenous aspirin but not by salicylate....Pages 165-166
Gastroduodenal alkaline secretion, mucosal defence of non-steroidal anti-inflammatory agents....Pages 167-168
Front Matter....Pages 169-169
Side-effects of penicillamine: some recent aspects....Pages 171-183
Front Matter....Pages 169-169
Side-effects of gold complexes and D-penicillamine: genetic aspects....Pages 185-199
Antimalarial-induced ocular toxicity during the treatment of rheumatoid arthritis....Pages 201-208
Clinical aspects and side-effects of sulphasalazine in the treatment of rheumatoid arthritis....Pages 209-221
Sulphasalazine: mode of action and side-effects in rheumatoid arthritis and ulcerative colitis....Pages 223-234
Side-effects of levamisole: recent aspects....Pages 235-244
Toxicology of immunoregulatory agents....Pages 245-252
Actions of novel immunoregulants useful in the treatment of arthritis as may be relevant to their toxicity....Pages 253-271
Monitoring for gold salt nephropathy and follow-up of gold-induced proteinuria by micro-PAGE electrophoresis....Pages 273-275
Long-term (up to 8 years) evaluation of side-effects of gold salts, levamisole and D-penicillamine in rheumatoid arthritis patients....Pages 277-278
Side-effect profile of sulphasalazine in inflammatory arthritis....Pages 279-280
Penicillamine-induced dermatomyositis and polymyositis....Pages 281-282
Front Matter....Pages 283-283
Pulsed intravenous methylprednisolone in the treatment of rheumatoid arthritis....Pages 285-292
Side-effects in SLE patients treated with methylprednisolone pulse therapy (MPPT)....Pages 293-301
Mechanisms of bone damage by glucocorticoids....Pages 303-309
Front Matter....Pages 311-311
Aspirin allergy....Pages 313-320
Genetic susceptibility towards NSAID-induced toxic epidermal necrolysis....Pages 321-329
Pathophysiology and pharmacology of asthma....Pages 331-344
Photosensitivity due to anti-inflammatory analgesic drugs: a laser flash photolysis study of azapropazone....Pages 345-354
Front Matter....Pages 355-355
Recent studies on the comparative nephrotoxicity of anti-inflammatory agents....Pages 357-366
Hospitalizations for renal impairment among users and non-users of non-steroidal anti-inflammatory drugs in Saskatchewan, Canada, 1983....Pages 367-375
Front Matter....Pages 355-355
Anti-inflammatory drugs and renal synthesis of prostaglandins and thromboxane in patients with systemic lupus erythematosus....Pages 377-392
The biochemical nephrotoxicity of anti-inflammatory and analgesic drugs: metabolic activation in the medulla and cortex....Pages 393-413
Free radical reactions during warm ischaemia and reperfusion of rabbit kidneys: potential therapeutic effects of desferrioxamine in renal transplantation....Pages 415-425
The effects of indomethacin, ketoprofen and piroxicam on basal and furosemide-induced sodium excretion in the healthy subject....Pages 427-428
Front Matter....Pages 429-429
Azapropazone is not a pyrazolidine derivative....Pages 431-438
The effect of benoxaprofen on thyroid function....Pages 439-441
The response of human platelets to aspirin in vitro....Pages 443-444
Differential influences of salsalate, aspirin and naproxen on plasma renin activity and platelet thromboxane (TxB) 2 synthesis....Pages 445-446
Antihypotensive effects of non-steroidal anti-inflammatory drugs: a study on thermal-induced hypotension....Pages 447-448
Mechanism of action of neuropeptides: a group of naturally occurring (endogenous) anti-inflammatory analgesic compounds....Pages 449-450
Back Matter....Pages 451-464