Sickle cell disease and hematopoietic stem cell transplantation

Front Matter ....Pages i-xiii
Front Matter ....Pages 1-1
 Clinical Manifestations of Sickle Cell Disease Across the Lifespan  (Lydia H. Pecker, Jane Little)....Pages 3-39
 Pathobiology of Sickle Cell Disease Vaso-occlusion and Targeted Therapies  (Kerry A. Morrone, Jennifer Davila, W. Beau Mitchell, Deepa Manwani)....Pages 41-64
 Current Non-HSCT Treatments for SCD  (Claire L. Anderson, Deepika S. Darbari)....Pages 65-86
 Risk-Based Therapies for Sickle Cell Disease  (Emily Riehm Meier)....Pages 87-110
 Transfusion Support of the Patient with Sickle Cell Disease Undergoing Transplantation  (Jeanne E. Hendrickson, Ross M. Fasano)....Pages 111-136
 Neurological Manifestations of Sickle Cell Disease and Their Impact on Allogeneic Hematopoietic Stem Cell Transplantation  (Jessica L. Carpenter, Monica L. Hulbert)....Pages 137-159
Front Matter ....Pages 161-161
 Overview of Hematopoietic Stem Cell Transplantation for Nonmalignant Diseases  (Karen L. Zimowski, Shanmuganathan Chandrakasan)....Pages 163-184
 Unique Challenges of Hematopoietic Stem Cell Transplant for Sickle Cell Disease  (Pooja Khandelwal, Michael Grimley)....Pages 185-198
 The Ethics of Hematopoietic Stem Cell Transplantation for Sickle Cell Disease  (Robert Sheppard Nickel, Naynesh Kamani)....Pages 199-219
 Psychosocial Care and Education of Children with Sickle Cell Disease Undergoing Hematopoietic Stem Cell Transplant and Their Families  (Steven J. Hardy, Jasmine R. Holt, Amanda L. Thompson)....Pages 221-233
 Long-Term Effects of Hematopoietic Stem Cell Transplantation for Sickle Cell Disease  (Karim T. Sadak, Angela R. Smith, Monica Bhatia)....Pages 235-249
 Matched Sibling Donor Hematopoietic Stem Cell Transplantation for Sickle Cell Disease  (Gregory M. T. Guilcher, John T. Horan)....Pages 251-269
 Unrelated Donor Hematopoietic Stem Cell Transplantation for Sickle Cell Disease  (Alexander Ngwube, Shalini Shenoy)....Pages 271-281
 Haploidentical Hematopoietic Cell Transplantation for Sickle Cell Disease  (Elizabeth O. Stenger, Allistair Abraham)....Pages 283-302
 Gene Therapy: The Path Toward Becoming a Realistic Cure for Sickle Cell Disease  (Alexis Leonard, Allistair Abraham)....Pages 303-328
Back Matter ....Pages 329-334