Severe Combined Immunodeficiency

Preface
Contents
1: Mucosal Immunity in Primary Immunodeficiencies
	1.1	 The MALT
	1.2	 Epithelia and Innate Mucosal Immunity in Respiratory Tract and Gut
	1.3	 Mucosal T Cells
		1.3.1	 Autoimmune Enteropathy, Regulatory T Cells, and IL-17 Production
		1.3.2	 CD4+ T Cell Depletion in Gut Mucosal and Chronic Granulomatous Disease
	References
2: Genetic Defects Associated with SCID and Their Impact on Lymphocyte Development
	2.1	 Introduction
	2.2	 Lymphocyte Development
	2.3	 Genetic Defects in SCID and Their Impact on Lymphocyte Development
		2.3.1	 Early Impairment of the Common Lymphoid Progenitor
		2.3.2	 Defective Signaling Through Cytokine Receptors
		2.3.3	 Defective V(D)J Recombination
		2.3.4	 Defective CD3 Complex and Pre-TCR Signaling
	2.4	 Conclusions and Future Perspectives
	References
3: Bioinformatics in Primary Immunodeficiencies: Towards a “Computational Immunology” Era
	3.1	 Introduction to Computational Immunology
	3.2	 Genomic Approaches in Immunodeficiency Research: A Structured Approach T