Serotonin: Current Aspects of Neurochemistry and Function

Front Matter....Pages i-xvi
Front Matter....Pages 1-5
Localization of Serotonin-Like Immunoreactivity in the Central Nervous System and Pituitary of the Rat, with Special References to the Innervation of the Hypothalamus....Pages 7-35
Serotonin Binding Protein: Role in Transmitter Storage in Central and Peripheral Serotonergic Neurons....Pages 37-49
Radioautographic Investigation of Serotonin Cells....Pages 51-66
Anatomical Evidence for GABA-5 HT Interaction in Serotonergic Neurons....Pages 67-79
Evidence for the Coexistence of Serotonin and Substance P in Single Raphe Cells and Fiber Plexuses: Combined Immunocytochemistry and Autoradiography....Pages 81-97
Front Matter....Pages 99-104
Effects of Peripherally and Centrally Administered Serotonin on Primate Spinothalamic Neurons....Pages 105-123
The Role of Serotonin in Modulation of Nociceptive Reflexes....Pages 125-151
Role of the Raphe Nuclei in Stimulation Producing Analgesia....Pages 153-176
Descending Control of Pain Transmission: Possible Serotonergic-Enkephalinergic Interactions....Pages 177-189
Front Matter....Pages 191-195
Synthesis and Quantitative Aspects of Dihydrobiopterin Control of Cerebral Serotonin Levels....Pages 197-206
Influence of Plasma Tryptophan on Brain 5HT Synthesis and Serotonergic Activity....Pages 207-219
Tryptophan Availability and the Control of 5-Hydroxytryptamine and Tryptamine Synthesis in Human CNS....Pages 221-230
Regulatory Properties of Neuronal Tryptophan Hydroxylase....Pages 231-251
Studies on the Oxygen Sensitivity of Tryptophan Hydroxylase....Pages 253-263
Influence of Histamine on Serotonin Metabolism in Rat Brain....Pages 265-275
Serotonin and Dopamine Synthesis in Phenylketonuria....Pages 277-291
Front Matter....Pages 293-298
Effect of Serotonin and Melatonin on the Electrophysiological Behaviour of the Plasma Membrane....Pages 299-318
Identification of Serotonin-Binding Proteins Using a Photoaffinity Labeling Probe....Pages 319-325
Serotonin-Receptors Coupled with an Adenylate Cyclase in the Rat Brain: Non-Identity with 3 H-5-HT Binding Sites....Pages 327-345
Brain Serotonin Receptors and Neuropsychiatric Disorders....Pages 347-357
Front Matter....Pages 293-298
Structure-Activity Relationships in the Actions of 1-Phenyl-Piperazines on Brain Serotonin Receptors....Pages 359-368
Front Matter....Pages 369-373
The Action of Serotonin in the Rat Hippocampus....Pages 375-390
Uptake and Metabolism of Serotonin and Amino Acids in Thiamine Deficiency....Pages 391-416
The Serotonin Connection: Some Evidence for a Specific Metabolic Organization....Pages 417-429
Role of Serotonin in the Hypothalamic Regulation of Pituitary Function....Pages 431-444
Evidence for Neuronal Feedback Regulation of Serotonin Formation in Brain....Pages 445-453
Front Matter....Pages 455-458
Neurohumor Substances as Neural Growth Factors....Pages 459-476
Roles for Serotonin in Neuroembryogenesis....Pages 477-506
Developmental-Regulatory Aspects of Brain Tryptophan Hydroxylase....Pages 507-523
Serotonin in Development of Cyclic Reproductive Function....Pages 525-539
Front Matter....Pages 541-545
The Interaction of Indole Derivatives with the Serotonin Receptor and Non-Dopaminergic Circling Behaviour....Pages 547-562
Some Behavioural Interactions between 5-Hydroxytryptamine and Dopamine....Pages 563-584
Serotonergic-Dopaminergic Interactions: Implications for Hyper-Kinetic Disorders....Pages 585-601
Serotonin Metabolism of Animal Model of Depression....Pages 603-625
Hypersensitive Serotonergic Receptors: A New Hypothesis for One Subgroup of Unipolar Depression Derived from an Animal Model....Pages 627-656
An Animal Behavior Model for Decreased Central Serotonergic Function....Pages 657-680
Studies on the Role of Central 5-HT Neurons in Avoidance Learning: A Behavioral and Biochemical Analysis....Pages 681-705
Front Matter....Pages 707-712
On the Clinical Significance of Serotonin and 5-HIAA in Body Fluids....Pages 713-717
Serotonin Metabolite Concentrations in Cerebrospinal Fluid from Schizophrenic Patients—Relationships to Family History....Pages 719-725
Tryptophan in the Treatment of Depression....Pages 727-737
Front Matter....Pages 707-712
Studies of CSF 5-HIAA in Depression and Suicidal Behaviour....Pages 739-752
Serotonin and Dopamine Disturbances in Patients with Unipolar Depressin and Parkinsonism....Pages 753-767
Abstracts....Pages 769-798
Back Matter....Pages 799-824