Serine Proteases and Their Serpin Inhibitors in the Nervous System: Regulation in Development and in Degenerative and Malignant Disease

Front Matter....Pages i-xxv
Front Matter....Pages 1-1
Thrombin Structural Regions in Determining Bioregulatory Functions....Pages 3-7
Regulation and Control of the Fibrinolytic System....Pages 9-20
A Key Molecule Dictating and Regulating Surface Plasmin Formation : The Receptor for Urokinase Plasminogen Activator....Pages 21-30
Regulation of Tissue Plasminogen Activator Secretion from Human Endothelial Cells....Pages 31-39
Thrombin Disintegrates Cell Surface Urokinase Focal Adhesion Plaques and Decreases Cell Extension: Implications for Axonal Growth....Pages 41-50
Structure and Function of Tissue-Type Plasminogen Activator....Pages 51-68
The Heparin Binding Site and Activation of Protease Nexin I....Pages 69-78
Polypeptide Chain Structure of Inter-α-Trypsin Inhibitor and Pre-α-Trypsin Inhibitor: Evidence for Chain Assembly by Glycan and Comparison with other “Kunin”-Containing Proteins....Pages 79-91
Regulation of Protease Nexin-1 Activity and Target Protease Specificity by the Extracellular Matrix....Pages 93-102
Front Matter....Pages 103-103
Induction of the Urokinase-Type Plasminogen Activator Gene by Cytoskeleton-Disrupting Agents....Pages 105-114
Use of Protein Chemistry and Molecular Biology to Determine Interaction Areas Between Proteases and their Inhibitors: The Thrombin-Hirudin Interaction as an Example....Pages 115-126
Signal Transduction Chains Involved in the Control of the Fibrinolytic Enzyme Cascade....Pages 127-135
Rodent Serpins : Accelerated Evolution and Novel Specificities....Pages 137-145
Structure of the Human Protease Nexin Gene and Expression of Recombinant Forms of PN-I....Pages 147-161
Evolutionary Adaptations of Serpins and their Use in Designing New Proteinase Inhibitors....Pages 163-170
Front Matter....Pages 171-171
Plasminogen Activator in the Developing Nervous System....Pages 173-184
Multiple Roles for Plasminogen Activator System in Nervous System Development....Pages 185-197
Interaction of Plasminogen Activators with the Neuronal Surface....Pages 199-208
Glial Plasminogen Activators in Developing and Regenerating Neural Tissue....Pages 209-217
Plasminogen Activators in Development, Injury and Pathology of the Neuromuscular System....Pages 219-228
Front Matter....Pages 171-171
Relationship Between Plasminogen Activators and Regeneration Capacities of Rat Skeletal Muscles....Pages 229-241
Front Matter....Pages 243-243
A Cascade Approach to Synapse Formation Based on Thrombogenic and Fibrinolytic Models....Pages 245-253
Localized Extracellular Proteolysis May Convey Inductive Signals Between Nerve and Muscle Cells During Synaptogenesis....Pages 255-273
Steps in Establishing a Biological Relevance for Glia-Derived Nexin....Pages 275-281
Front Matter....Pages 283-283
Protease Inhibitors in Neurologic Diseases....Pages 285-291
Presence and Significance of α 1 -Antitrypsin in Human Brain Tumors....Pages 293-299
Serpins and Brain Tumors: Roles in Pathogenesis....Pages 301-311
A Serine Protease Inhibitor Domain Encoded Within the Alzheimer Disease-Associated Amyloid ß -Protein Precursor Gene....Pages 313-319
The Serpin, α 1 -Antichymotrypsin, in Brain Aging and Diseases of the Nervous System....Pages 321-327
Protease Nexin I Immunostaining in Alzheimer’s Disease....Pages 329-336
Back Matter....Pages 337-359