Selenium: Its Molecular Biology and Role in Human Health

Front Matter....Pages i-xxxi
Front Matter....Pages 1-1
Selenocysteine tRNA[Ser]Sec: From Nonsense Suppressor tRNA to the Quintessential Constituent in Selenoprotein Biosynthesis....Pages 3-12
Eukaryotic Mechanisms of Selenocysteine Incorporation and Its Reconstitution In Vitro....Pages 13-24
Probing Selenoprotein Translation by Ribosome Profiling....Pages 25-37
Pathways in De Novo Biosynthesis of Selenocysteine and Cysteine in Eukaryotes....Pages 39-45
Prokaryotic Selenoprotein Biosynthesis and Function....Pages 47-58
The Role of Selenium in Human Evolution....Pages 59-71
The Chemistry of Selenocysteine in Proteins....Pages 73-83
Evolution of Selenophosphate Synthetase....Pages 85-99
Structure and Mechanism of Selenocysteine Synthases....Pages 101-112
Mechanism, Structure, and Biological Role of Selenocysteine Lyase....Pages 113-123
Front Matter....Pages 125-125
Eukaryotic Selenoproteomes....Pages 127-139
Prokaryotic Selenoproteins and Selenoproteomes....Pages 141-150
Functional Genomics of Selenoproteins and Se-responsive Pathways....Pages 151-173
Selenium Regulation of the Selenoprotein and Non-selenoprotein Transcriptomes in a Variety of Species....Pages 175-186
Thioredoxin Reductase 1 as an Anticancer Drug Target....Pages 187-198
Basics and News on Glutathione Peroxidases....Pages 199-209
Glutathione Peroxidase 4....Pages 211-222
The 15 kDa Selenoprotein: Insights into Its Regulation and Function....Pages 223-234
Selenoprotein K and Protein Palmitoylation in Regulating Immune Cell Functions....Pages 235-243
Front Matter....Pages 245-252
Selenoprotein M: Structure, Expression and Functional Relevance....Pages 125-125
Selenoprotein P and Selenium Distribution in Mammals....Pages 253-260
Selenoprotein T: From Discovery to Functional Studies Using Conditional Knockout Mice....Pages 261-274
Biochemistry and Function of Methionine Sulfoxide Reductase....Pages 275-286
Front Matter....Pages 287-292
Selenium: Dietary Sources, Human Nutritional Requirements and Intake Across Populations....Pages 293-293
Human Clinical Trials Involving Selenium....Pages 295-305
Status of Dietary Selenium in Cancer Prevention....Pages 307-319
Selenium in HIV/AIDS....Pages 321-332
Genetic Variations in the Genes for Selenoproteins Implicate the Encoded Proteins in Cancer Etiology....Pages 333-342
Is Adequate Selenium Important for Healthy Human Pregnancy?....Pages 343-352
The Epidemiology of Selenium and Human Health....Pages 353-364
Sex-Specific Differences in Biological Effects and Metabolism of Selenium....Pages 365-376
Selenium and Endocrine Tissues....Pages 377-388
Selenium Antagonism with Mercury and Arsenic: From Chemistry to Population Health and Demography....Pages 389-400
Biological Selenium Species and Selenium Speciation in Biological Samples....Pages 401-412
Front Matter....Pages 413-424
Selenoproteins in Nervous System Development, Function and Degeneration....Pages 425-425
Interplay of Selenoproteins and Different Antioxidant Systems in Various Cancers....Pages 427-439
Glutathione Peroxidase 2, a Selenoprotein Exhibiting a Dual Personality in Preventing and Promoting Cancer....Pages 441-449
Selenoproteins in Cardiovascular Redox Pathology....Pages 451-462
What Do We Know About Selenium Contributions to Muscle Physiology?....Pages 463-474
Front Matter....Pages 475-486
Tissue-Specific Regulation of Thyroid Status by Selenodeiodinases....Pages 425-425
The Role of Selenoproteins in Resolution of Inflammation....Pages 487-498
Glutathione Peroxidase 4 and Ferroptosis....Pages 499-510
Mutations in Humans That Adversely Affect the Selenoprotein Synthesis Pathway....Pages 511-521
Alteration of Selenoprotein Expression During Stress and in Aging....Pages 523-538
Front Matter....Pages 539-551
Selenocysteine tRNA[Ser]Sec Mouse Models for Elucidating Roles of Selenoproteins in Health and Development....Pages 553-553
Mouse Models that Target Individual Selenoproteins....Pages 555-566
The Naked Mole Rat and Selenium....Pages 567-578
Glutathione Peroxidase 1: Models for Diabetes and Obesity....Pages 579-585
Selenium in Livestock and Other Domestic Animals....Pages 587-594
Back Matter....Pages 595-606
....Pages 607-628