Selenium: Its Molecular Biology and Role in Human Health

Selenium: A historical perspective....Pages 1-6
Front Matter....Pages 7-7
Selenium metabolism in prokaryotes....Pages 9-28
Mammalian and other eukaryotic selenocysteine tRNAs....Pages 29-37
Evolution of selenocysteine decoding and the key role of selenophosphate synthetase in the pathway of selenium utilization....Pages 39-50
SECIS RNAs and K-turn binding proteins. A survey of evolutionary conserved RNA and protein motifs....Pages 51-61
SECIS binding proteins and eukaryotic selenoprotein synthesis....Pages 63-72
The importance of subcellular localization of SBP2 and EFsec for selenoprotein synthesis....Pages 73-82
Selenocysteine biosynthesis and incorporation may require supramolecular complexes....Pages 83-95
Front Matter....Pages 97-97
Selenoproteins and selenoproteomes....Pages 99-110
Deletion of selenoprotein P gene in the mouse....Pages 111-122
Selenium and methionine sulfoxide reduction....Pages 123-133
Selenoprotein W in development and oxidative stress....Pages 135-140
The 15-kDa selenoprotein (Sep15): functional analysis and role in cancer....Pages 141-148
Regulation of glutathione peroxidase-1 expression....Pages 149-160
Selenoproteins of the glutathione system....Pages 161-172
New roles of glutathione peroxidase-1 in oxidative stress and diabetes....Pages 173-182
Selenoproteins of the thioredoxin system....Pages 183-193
Mitochondrial and cytosolic thioredoxin reductase knockout mice....Pages 195-206
Selenium, deiodinases and endocrine function....Pages 207-219
Biotechnology of selenocysteine....Pages 221-230
Front Matter....Pages 231-231
Selenium, selenoproteins and brain function....Pages 233-248
Selenium as a cancer preventive agent....Pages 249-264
Peering down the kaleidoscope of thiol proteomics and unfolded protein response in studying the anticancer action of selenium....Pages 265-276
Genetic variation among selenoprotein genes and cancer....Pages 277-286
Selenium and viral infections....Pages 287-298
Role of selenium in HIV/AIDS....Pages 299-310
Effects of selenium on immunity and aging....Pages 311-322
Selenium and male reproduction....Pages 323-331
Mouse models for assessing the role of selenoproteins in health and development....Pages 333-341
 Drosophila as a tool for studying selenium metabolism and role of selenoproteins....Pages 343-353
Selenoproteins in parasites....Pages 355-366
Incorporating ‘omics’ approaches to elucidate the role of selenium and selenoproteins in cancer prevention....Pages 367-378
Selenium-induced apoptosis....Pages 379-385
Selenoprotein mimics....Pages 387-398
Update of human dietary standards for selenium....Pages 399-410