Secretory Immunity and Infection: Proceedings of the International Symposium on the Secretory Immune System and Caries Immunity

Front Matter....Pages i-xxi
New Areas Arising from Studies of Secretory Immunity....Pages 1-8
Generation of Clonal and Isotype Diversity....Pages 9-17
Cellular Parameters of the IgA Response....Pages 19-28
Lymphatic Physiology and Secretory Immunity....Pages 29-34
Development of the IgA System in the Mammary Gland....Pages 35-42
Effect of Anti-IgD Serum on Immune Responses....Pages 43-51
A Common Mucosal Immunologic System Involving the Bronchus, Breast and Bowel....Pages 53-59
Discussion....Pages 61-66
Migration Pathways of T Lymphocytes in the Small Intestine....Pages 67-74
Cell-Mediated Immunity on Secretory Surfaces....Pages 75-85
Immunoglobulin a Production by Human Colostral Cells: Quantitative Aspects....Pages 87-94
Immunologic Aspects of Human Colostrum and Milk: Interaction with the Intestinal Immunity of the Neonate....Pages 95-107
Discussion....Pages 109-112
Remote-Site Stimulation of Secretory IgA Antibodies Following Bronchial and Gastric Stimulation....Pages 113-122
Development of Humoral Antibody Following the Ingestion of Soluble Protein Antigen by Passively Immunized Animals....Pages 123-132
Elimination of Escherichia Coli K88 Adhesion Determinant by Antibody in Porcine Gut and Mammary Secretions Following Oral Immunization....Pages 133-142
Cellular Aspects of the Murine Anti-Hapten IgA Response....Pages 143-150
Discussion....Pages 151-154
Characterization of Immunoglobulin-Containing Cells in the Submandibular Gland of the Rat after Local Immunization....Pages 155-164
Secretory IgA Antibodies to Enterobacterial Virulence Antigens: Their Induction and Possible Relevance....Pages 165-176
Induction of Secretory Antibodies in Humans Following Ingestion of Streptococcus Mutans ....Pages 177-184
Concept of the Local and Common Mucosal Immune Response....Pages 185-192
Discussion....Pages 193-198
T-Cell Regulation of Murine Iga Biosynthesis....Pages 199-208
Molecular-Cellular Interactions in the Secretory IgA System....Pages 209-217
Further Evidence for a Role of Secretory Component (SC) and J Chain in the Glandular Transport of IgA....Pages 219-226
Influence of Parenteral Immunization in Rabbits on the Penetrability of Oral Mucosa for Macromolecules....Pages 227-232
Role of the Liver in the Rat Intestinal s-IgA System....Pages 233-239
Transport of Oligomeric Iga of Systemic Origin Into External Secretions....Pages 241-251
Discussion....Pages 253-259
Effective Immunity to Dental Caries: Selective Induction of Secretory Immunity by Oral Administration of Streptococcus Mutans in Rodents....Pages 261-269
Cross-Protective Aspects of Glucosyltransferase Antigens in the Hamster Caries Model....Pages 271-279
Antigens of Streptococcus Mutans Implicated in Virulence — Production of Antibodies....Pages 281-292
The Effect of Cyclosporin a on Dental Caries in Rats Monoassociated with Actinomyces Viscosus NY 1....Pages 293-301
Passive Immunization with Antisera to Streptococcus Mutans in the Prevention of Caries in Rhesus Monkeys....Pages 303-315
Antibody Binding of Glucosyltransferase Enzyme Preparations from Homologous and Heterologous Serotypes of S. Mutans ....Pages 317-325
Daucus Carrota (Carrot) — A Selective Bacteriosorbent....Pages 327-333
Discussion....Pages 335-339
Studies of Secretory IgA in Caries-Resistant and Caries-Susceptible Adults....Pages 341-348
Antibodies Reacting with Streptococcus Mutans in Secretions from Minor Salivary Glands in Humans....Pages 349-354
Salivary IgA Antibodies to Antigens from Streptococcus Mutans in Human Dental Caries....Pages 355-367
Antibodies Against Streptococcus Mutans and Glucosyltransferases In Caries-Free and Caries-Active Military Recruits....Pages 369-381
Immunoglobulins and Antibodies in Plaque Fluid and Saliva in Two Populations with Contrasting Levels of Caries....Pages 383-392
Discussion....Pages 393-400
Secretory Immunity and Immunodeficiency....Pages 401-410
The Partial Isolation and Function of Salivary Factors Which Interact with the Complement System: a Possible Role in Mucosal Immunity....Pages 411-421
Discussion....Pages 423-427
Adhesion and Chemotaxis as Determinants of Bacterial Association with Mucosal Surfaces....Pages 429-437
The Role of Antigen form and the Induction of an Intestinal Immune Response to Cholera Toxin/Toxoid in Rats....Pages 439-445
Motility of the Pathogen and Intestinal Immunity of the Host in Experimental Cholera....Pages 447-455
Discussion....Pages 457-459
Prevention of Bacterial Infections of Mucosal Surfaces by Immune Secretory IgA....Pages 461-470
Studies on Oral Adjuvants Against Murine Salmonellosis....Pages 471-477
Cell Mediated Immune Responses to Bacterial Antigens on Human Mucosal Surfaces....Pages 479-488
Assay and Properties of IgA Protease of Streptococcus Sanguis ....Pages 489-495
Discussion....Pages 497-501
A Comparison of Secretory Component — Immunoglobulin Interactions Amongst Different Species....Pages 503-511
Serologic and Structural Comparisons of Rabbit IgA Allotypes....Pages 513-522
Milk Precipitins, Circulating Immune Complexes and IgA Deficiency....Pages 523-530
Regulation by Sex Hormones of Immunoglobulins in Rat Uterine and Vaginal Secretions....Pages 531-539
Discussion....Pages 541-546
Effect on Rat IgA Synthesis by Isotypic Suppression with an Anti-Rat Delta Heavy Chain Serum....Pages 547-552
Immunoglobulin A in Secretions from the Lower Human Respiratory Tract....Pages 553-564
Measurement of IgA Memory to 2,4-Dinitrophenyl (DNP) in the Sera of Adoptive Recipient Rats Using the Amplified Elisa....Pages 565-574
Human Mucosal Lymphocytes — Memory for ‘Recall’ Antigens and Non-Specific Suppression by T-Lymphocytes....Pages 575-582
Response of Anamnestic IgA-Producing Cells in the Mouse Gut After Repeated Intragastric Immunization....Pages 583-591
Detection of IgA Anti- Escherichia Coli Plasma Cells in the Intestine and Salivary Glands of Pigs Orally and Locally Infected with E. Coli ....Pages 593-600
Discussion....Pages 601-605
Lipoteichoic Acid — The Key to the Adhesiveness of Sucrose Grown Streptococcus Mutans ....Pages 607-617
Amphipathic Antigens of Oral Microorganisms — Immunogenicity and Other Biological Properties....Pages 619-628
Effect of Growth Conditions on the Antigenic Components of Streptococcus Mutans and Lactobacilli....Pages 629-637
Modification of in Vitro Adherence of Streptococcus Mutans by Plant Lectins....Pages 639-647
Search for Cross-Reacting Antigens of Oral Acidogenic Bacteria and Members of the Normal Intestinal Flora....Pages 649-653
Discussion....Pages 655-659
Genetic Alterations of Streptococcus Mutans’ Virulence....Pages 661-672
Use of Mutants in the Elucidation of Virulence of Streptococcus Mutans ....Pages 673-683
Wall Carbohydrate Antigens of A. Israelii ....Pages 685-693
Fimbriae of Actinomyces Viscosus T14V: Their Relationship to the Virulence-Associated Antigen and to Coaggregation with Streptococcus Sanguis 34....Pages 695-701
Preliminary Results in the Immunization of Irus Monkeys Against Dental Caries....Pages 703-712
Discussion....Pages 713-715
 Streptococcus Mutans Dextransucrase: Phosphoglycerides and the Detection of Inhibitory Antibodies in Sera....Pages 717-725
Interaction of Streptococcus Mutans Glucosyltransferases with Antibodies....Pages 727-736
Dextran/Glucan Binding by Streptococcus Mutans : The Role of Molecular Size and Binding Site in Agglutination....Pages 737-748
Multiple Forms of Dextran-Binding Proteins from Streptococcus Mutans ....Pages 749-759
Discussion....Pages 761-763
General Discussion....Pages 765-770
Dextran Receptors as Immunogens in Caries Prophylaxis....Pages 771-781
Antigenicity and Immunogenicity of Cell-Associated Glucans from Streptococcus Mutans ....Pages 783-790
A Comparison of the Phenol Water and Rantz and Randall Teichoic Acid Antigens in Group H Streptococci....Pages 791-802
Turnover and Excretion of Streptococcal Surface Components....Pages 803-814
Discussion....Pages 815-816
Fluorescence Quantitation of S-IgA in Parotid Saliva and of S-IgA Bound to Oral Microorganisms....Pages 817-827
Antigenic Variation in Populations of Oral Streptococci....Pages 829-838
Salivary Immunoglobulins in Diseases Affecting Salivary Glands....Pages 839-847
Whole Saliva Proteases: Development of Methods for Determination of Origins....Pages 849-858
Extrachromosomal Gene Systems in Streptococcus Mutans ....Pages 859-868
Bacterial Adherence Related to Agglutination and Surface Film Formation....Pages 869-875
Discussion....Pages 877-881
Report of the Summation Committee: Recommended Areas for Future Research....Pages 883-888
Back Matter....Pages 889-905