Screening and Risk Reduction Strategies for Breast Cancer: Imaging Modality and Risk-Reduction Approaches

Foreword
Preface
Acknowledgements
Contents
Advances in Breast Cancer Screening: Precision, Imaging, and Harms
	Epidemiology
	Precision Medicine, Fine Staging, Precise Prediction of Prognosis, and Escalation/De-escalation in Treatment
	Screen-Detected Breast Cancer
	DCIS
	AGE Issues
	Dense Breasts
	Digital Breast Tomosynthesis (DBT)
	Ultrasound, MRI, and PET for Screening
	Harms
	Biology of Interval Cancers
	Conclusion
	References
Breast Cancer Risk Assessment Models and Multi-Cancer Early Detection Tests
	Risk Assessment Tools (RATs)
	Validation of RATs
	Polygenic Risk Score in Breast Cancer Risk Assessment
	Tumor Growth and Early Detection
	RATs and Clinical Trials
	Blood Tests and Multi-Cancer Early Detection
	MCEDs and Clinical Trials
	Conclusion
	References
Hereditary Breast Cancer and Pathogenic Germline Variants
	Introduction
	Pathogenic Germline Variants and Incidence
	Germline Variants and Cancer Occurrence
	Germline Variants on Cancer Pathogenesis
	PGVs and Somatic Abnormalities
	PGV and Chemotherapy Sensitivity
	PARP Inhibitors for BC Patients Carrying PGVs
	PGVs, Prognosis and Survival Prediction, Role in BC Immune Microenvironment
	Conclusion
	References
Over-Diagnosis and Breast Cancer Screening
	Introduction
	Trials of Breast Cancer Screening
	Ductal Carcinoma In Situ
	Evidence for Over-Diagnosis
	Harms of Breast Cancer Screening
	Assessing the Efficacy of Breast Screening Modalities
	Conclusions
	References
Breast Cancer Screening with MRI in Women with Over 20% Lifetime Risk
	Introduction: Can Screening Reduce Mortality in Women with Increased Breast Cancer Risk?
	Methods and Results of the Randomized FaMRIsc and DENSE MRI-Screening Trials in Women with ≥20% Lifetime BC Risk
	Cost-Effectiveness of MRI-Screening for ≥20% BC Risk
	Preference of High-Risk Women for MRI
	Discussion
	References
MRI for Breast Cancer Screening: Technical Consideration
	Introduction
	Abbreviated Breast MRI
	Ultrafast Dynamic Contrast-Enhanced (UF-DCE) MRI
	Unenhanced MRI Including Diffusion-Weighted Imaging (DWI)
	Feasibility of Breast MRI Screening
	Conclusion
	References
Risk-Reducing Surgery for Breast Cancer
	Introduction
	Risk Factors for Breast Cancer
		High-Risk Predisposing Genes
		Low/Intermediate-Risk Predisposing Genes
	Genetic Testing and Risk Prediction
	Management Options for Women with High-Penetrance Mutations
	Risk-Reducing Surgery for Women with High-Penetrance Gene Mutations
	Contralateral Prophylactic Mastectomy in Mutation Carriers
	Surgical Techniques
	Conclusion
	References
Cost-Effectiveness of Genetic Testing Strategies for Breast Cancer
	Genetic Susceptibility in Breast Cancer
	Current Strategy of Genetic Testing and Its Limitations
	Clinical Benefits of Genetic Testing in Women with BC
	Routine Genetic Testing at Breast Cancer Diagnosis
	Cost-Effectiveness of Routine Genetic Testing at Breast Cancer Diagnosis
		Clinical Criteria or FH-Based Testing at BC Diagnosis
		Genetic Testing for All at BC Diagnosis
	Barriers and Solutions for Implementing Increased Testing
	Population-Based Genetic Testing
	Cost-Effectiveness of Population-Based Genetic Testing
		BRCA Testing in the Jewish Population
		CSG Testing in the Non-Jewish General Population
	Conclusion
	References
Biomarkers in Proteomics
	Development of Proteomics
	Methods of Clinical Proteomics
	Discovering Biomarker Candidates in Proteomics
	Proteomics Application in Clinic
	Future Biomarker Science
	References
Ultrasound in Breast Cancer Screening
	Introduction
	Breast Ultrasound Screening Trials
	Ultrasound Screening for High-Risk Women
	Evaluation of Adjunctive Ultrasound Screening with Varying Breast Density
	Simultaneous Interpretation of US and MG for a Decrease in Recall Rate
	Future Directions of Ultrasound Breast Cancer Screening (On-Going Trial)
	Conclusions
	References
Detection of Breast Cancer by PET
	Introduction
	Types of High-Resolution Breast PET Systems and Examination Protocols
	Interpretive Criteria: Lexicon
	Detection of Cancers with Breast PET
	Breast Cancer Screening Using PET and Breast PET
	Summary
	References
Inverse Scattering Problem and Microwave Mammography
	Clinical Research
	Conclusion
	References
Photoacoustic Imaging of Breast Cancer
	Introduction
	Principle of Photoacoustic Imaging
	Application of Photoacoustic Imaging to Breast Cancer
	Future Directions
	Conclusion
	References
Japanese Breast Cancer Screening: Challenges and Hopes
	Twenty Years of Mammography Screening
	Current Challenges
	References