Russell, Hugo & Ayliffe's Principles and Practice of Disinfection, Preservation & Sterilization

Cover......Page 1
Contents......Page 6
List of contributors......Page 8
Preface to the fourth edition......Page 9
Preface to the first edition......Page 11
Part 1: Principles......Page 12
1. Historical introduction......Page 14
2. Types of antimicrobial agents......Page 19
3. Factors influencing the efficacy of antimicrobial agents......Page 109
4. Biofilms and antimicrobial resistance......Page 139
5. Mechanisms of action of biocides......Page 150
6.1 Intrinsic resistance of Gram-negative bacteria......Page 165
6.2 Acquired resistance......Page 181
6.3 Resistance of bacterial spores to chemical agents......Page 194
6.4 Mycobactericidal agents......Page 202
7.1 Antifnungal activity of biocides......Page 216
7.2 Evaluation of the antibacterial and antifnungal activity of disinfectants......Page 230
8.1 Acanthamoeba, contact lenses and disinfection......Page 251
8.2 Intestinal protozoa and biocides......Page 269
9. Viricidal activity of biocides......Page 283
10. Transmissible degenerative encephalopathies: inactivation of the unconventional causal agents......Page 335
Part 2: Practice......Page 354
11. Evaluation of antimicrobial efficacy......Page 356
12. Sterilization......Page 371
12.1 Heat sterilization......Page 372
12.2 Radiation sterilization......Page 395
12.3 Gaseous sterilization......Page 412
12.4 Filtration sterilization......Page 447
13. New and emerging technologies......Page 484
14. Preservation of medicines and cosmetics......Page 494
15. Reuse of single-use devices......Page 525
16. Sterility assurance: concepts, methods and problems......Page 537
17. Special problems in hospital antisepsis......Page 551
18. Decontamination of the environment and medical equipment in hospitals......Page 574
19. Treatment of laundry and clinical waste in hospitals......Page 597
20.1 Special issues in dentistry......Page 606
20.2 Veterinary practice......Page 615
20.3 Recreational and hydrotherapy pools......Page 625
21. Good manufacturing practice......Page 633
Index......Page 652