Risk Assessment in Chemical Carcinogenesis

Front Matter....Pages I-IX
Risk Assessment and Management of Toxic Chemicals: The Needs and Guidelines for Developing Countries....Pages 1-6
Front Matter....Pages 7-7
Individual genetic constellations as risk factors in chemical carcinogenesis....Pages 9-16
Mechanistic Analysis as a Tool for Carcinogen Risk Assessment....Pages 17-23
Molecular Genetic Alterations such as Oncogene Activation as a Tool for the Evaluation of Risks in Chemical Carcinogenesis....Pages 24-32
Initiation and Promotion — Useful Concepts for Risk Assessment?....Pages 33-37
Front Matter....Pages 39-39
Risk Assessment of Naturally Occurring Carcinogens....Pages 41-55
Carcinogenic Drugs and their Relevance in Risk Assessment....Pages 56-63
A Weight-of-Evidence Approach to Quantitative Cancer Risk Assessment: Information Analysis....Pages 64-78
Biologically Based Pharmacokinetics and Cancer Risk Assessment....Pages 79-92
Evaluation of Epidemiologic Study Designs for the Assessment of Risk in Chemical Carcinogenesis....Pages 93-103
The role of ‘negative’ and ‘nonpositive’ studies in occupational epidemiology....Pages 104-112
Weak Associations in Occupational Epidemiology and the Criteria for Deducing Causality....Pages 113-122
Aspects of Clinical Oncology in the Assessment in Chemical Carcinogenesis....Pages 123-136
Front Matter....Pages 137-137
Provisions on carcinogenic substances in the Federal Republic of Germany and the European Community....Pages 139-148
Regulations on Chemical Carcinogens of the Environmental Protection Agency....Pages 149-159
Regulation of Chemical Carcinogenesis in Japan....Pages 160-168
Back Matter....Pages 169-172