Ribosomes

Contents......Page 1
Preface......Page 8
Part I. Historical and Fundamental Introduction......Page 9
1. Protein Biosynthesis: Summary and Definitions......Page 11
2. Messenger RNA and the Genetic Code......Page 13
3. Transfer RNA and Aminoacyl-tRNA Synthetases......Page 27
4. Ribosomes and Translation......Page 45
Part II. Structure of the Ribosome......Page 57
5. Morphology of the Ribosome......Page 59
6. Ribosomal RNA......Page 69
7. Ribosomal Proteins......Page 87
8. Mutual Arrangement of Ribosomal RNA and Proteins (Quaternary Structure)......Page 103
Part III. Function of the Ribosome......Page 113
9. Functional Activities and Functional Sites of the Ribosome......Page 115
10. Elongation Cycle, Step I: Aminoacyl-tRNA Binding......Page 139
11. Elongation Cycle, Step II: Transpeptidation (Peptide Bond Formation)......Page 163
12. Elongation Cycle, Step III: Translocation......Page 175
13. Elongation Rate and Its Modulation......Page 197
14. Termination of Translation......Page 213
15. Initiation of Translation......Page 221
16. Translational Control in Prokaryotes......Page 257
17. Translational Control in Eukaryotes......Page 283
18. Cotranslational Folding and Transmembrane Transport of Proteins......Page 309
19. Conclusion: General Principles of Ribosome Structure and Function......Page 331