Reviews of Environmental Contamination and Toxicology

Cover
 Series Introduction
 Preface
 About the Editors
 Contributors
 Contents
 1 Application of Nutrigenomics Tools to Analyze the Role of Oxidants and Antioxidants in Gene Expression
 WHAT IS NUTRIGENOMICS?
 DO OXIDANTS AND ANTIOXIDANTS AFFECT GENE EXPRESSION?
 METHODS AND APPLICATIONS IN NUTRIGENOMICS
 REFERENCES
 2 Oxidative Stress and Human Genetic Variation
 MANGANESE SUPEROXIDE DISMUTASE
 COPPER, ZINC SUPEROXIDE DISMUTASE
 THE GLUTATHIONE-S-TRANSFERASES
 THE GST GENES
 GLUTATHIONE-S-TRANSFERASE T1
 Functional Studies of the 894G>
 T (Glu298Asp) Polymorphism. Potential Dietary InterventionsCATALASE
 NADPH OXIDASE
 NADPH Oxidase Background
 NADPH Polymorphisms
 NADPH Polymorphisms and Health Conditions
 GLUTATHIONE PEROXIDASE
 MYELOPEROXIDASE
 NADPH DEHYDROGENASE, QUINONE 1
 NADPH Background
 NADPH Polymorphisms
 CONCLUSION
 REFERENCES
 3 Analysis of Microarray Data
 INTRODUCTION
 NORMALIZATION METHODS
 Per Array Normalization
 Per Gene Normalizations
 DATA ANALYSIS
 Fold Changes in Expression Levels
 Class Discovery-Unsupervised Learning Methods
 Class Prediction-Supervised Learning Methods
 VALIDATION OF MICROARRAY ANALYSIS. Laboratory Based ValidationMICROARRAY ANALYSIS SOFTWARE
 SUMMARY
 REFERENCES
 4 Oxidative Stress, Gene Expression, and Lifespan
 INTRODUCTION
 LIFESPAN REGULATION IN C. ELEGANS Aging of C. elegans
 Stress, Hormesis, and Lifespan in C. elegans
 Insulin/IGF-I Signaling and Lifespan Regulation
 Insulin/IGF-I Signaling Pathway and Stress Resistance
 DAF-16 Transcription Target
 Reproductive System and Lifespan
 Nervous System and Lifespan
 Mitochondrial Electron Transport and Lifespan
 LIFESPAN REGULATION IN DROSOPHILA
 LIFESPAN REGULATION IN MAMMALS
 REPLICATIVE LIFESPAN AND OXIDATIVE STRESS. CONCLUSIONREFERENCES
 5 Anti-Oxidant Modulation in Immune Function
 INTRODUCTION
 THE IMMUNE RESPONSE TO INFECTION INJURY AND INFLAMMATORY AGENTS
 THE FUNCTION OF PRO-INFLAMMATORY CYTOKINES DURING THE NORMAL RESPONSE TO INFECTION AND INJURY
 ADVERSE EFFECTS OF PRO-INFLAMMATORY CYTOKINES
 ANTI-OXIDANT DEFENSES ARE INTERLINKED AND INTERDEPENDENT
 A DECLINE IN ANTI-OXIDANT DEFENSES AND INCREASED OXIDANT DAMAGE FOLLOWS INFECTION AND INJURY
 AGING INCREASES OXIDATIVE AND INFLAMMATORY STRESS
 Mechanisms Underlying Low-Grade Inflammation During Aging. MECHANISMS OF THE EFFECTS OF OXIDANTS AND ANTI-OXIDANTS ON INFLAMMATION AND IMMUNE FUNCTIONEFFECTS OF ANTI-OXIDANTS ON IMMUNE FUNCTION Effects of Vitamin E
 Ascorbic Acid and Immune Function
 Glutathione and Immune Function
 EFFECTS OF SUBSTANCES THAT ACT AS PRECURSORS FOR GSH OR COFACTORS IN ENZYME PATHWAYS ASSOCIATED WITH GSH ON IMMUNE FUNCTION Effects of Precursors of GSH on Immune Function
 Effects of Vitamin B6 on Immune Function
 Effects of Folic Acid on Immune Function
 Taurine and Immune Function
 CONCLUSIONS
 REFERENCES.