Retinal Degenerations: Biology, Diagnostics and Therapeutics (Ophthalmology Research)

CoverPage......Page 1
FrontMatter......Page 2
TitlePage......Page 4
CopyRight......Page 5
Preface......Page 6
Contents......Page 12
Contributors......Page 16
Section I: LIVING WITH RETINAL DEGENERATION......Page 22
1 Coping With Retinal Degeneration......Page 24
Section II: DEGENERATIVE DISEASES OF THE RETINA......Page 42
2 Epidemiology of Age-Related MacularDegeneration Early in the 21st Century......Page 44
3 Leber Congenital Amaurosis......Page 82
4 Macular Degeneration......Page 112
5 Stargardt Disease......Page 126
6 X-Linked Juvenile Retinoschisis......Page 140
7 Retinal Degeneration in Usher Syndrome......Page 158
8 Mouse Models of RP......Page 170
Section III: MECHANISMS UNDERLYING RETINALDEGENERATIONS......Page 184
9 The Impact of Diabetes on Neuronal, Glial,and Vascular Cells of the Retina......Page 186
10 Statins and Age-Related Maculopathy......Page 206
11 The Role of Drusen in Macular Degenerationand New Methods of Quantification......Page 218
12 RPE Lipofuscin......Page 234
13 Genetic Modifiers That Affect PhenotypicExpression of Retinal Diseases......Page 258
14 X-Linked Retinal Dystrophies and MicrotubularFunctions Within the Retina......Page 278
15 Synaptic Remodeling in Retinal Degeneration......Page 290
Section IV: DEVELOPING THERAPEUTIC STRATEGIESFOR RETINAL DEGENERATIVE DISEASES......Page 312
16 On The Suppression of Photoreceptor Cell Deathin Retinitis Pigmentosa......Page 314
17 Cell-Based Therapies to Restrict the Progressof Photoreceptor Degeneration......Page 340
18 Current Status of IPE Transplantationand Its Potential as a Cell-Based Therapyfor Age-Related Macular Degenerationand Retinal Dystrophies......Page 366
19 Recent Results in Retinal TransplantationGive Hope for Restoring Vision......Page 386
20 Stem Cells and Retinal Transplantation......Page 406
21 Application of Encapsulated Cell Technologyfor Retinal Degenerative Diseases......Page 422
22 Effective Treatment for the Canine RPE65Null Mutation, a Hereditary RetinalDystrophy Comparable to Human Leber’sCongenital Amaurosis......Page 436
23 Neuroprotective Factors and Retinal Degenerations......Page 454
24 Carbonic Anhydrase Inhibitors as a PossibleTherapy for RP17, an Autosomal DominantRetinitis Pigmentosa Associated With the R14WMutation, Apoptosis, and the UnfoldedProtein Response......Page 476
25 Macular Degeneration—An Addendum......Page 480
INDEX......Page 484