Research and development of opioid-related ligands

 Content: PREFACE ; COMMENTARIES ; 1. COMMENTARY ON THE CURRENT STATUS OF CLINICALLY USED ANALGESICS ; THOMAS M. DODDS ; 2. COMMENTARY ON THE CURRENT STATE OF OPIOID-RELATED RESEARCH ; JOHN W. LEWIS ; CLINICAL STUDIES OF PAIN AND OPIOIDS ; 3. THE CLINICAL IMPORTANCE OF CONDITIONING PAIN MODULATION: A REVIEW AND ; CLINICAL IMPLICATIONS ; MELLAR P. DAVIS ; 4. TREATMENT OF PAIN AND OPIOID ABUSE ; SHANTHI MOGALI AND SANDRA D. COMER ; 5. TREATMENT OF OPIOID DEPENDENCE ; ANDREW J. SAXON ; 6. BUPRENORPHINE IN THE TREATMENT OF NEUROPATHIC PAIN ; GUY H. HANS ; DEVELOPMENT OF NEW LIGANDS ; 7. BUPRENORPHINE AND RELATED ORVINOLS ; STEPHEN M. HUSBANDS ; 8. STRUCTURE-ACTIVITY RELATIONSHIPS OF NOCICEPTIN RECEPTOR (NOP) LIGANDS ; AND THE DESIGN OF BIFUNCTIONAL NOP/MU OPIOID RECEPTOR-TARGETED ; LIGANDS ; NURULAIN T. ZAVERI, DENNIS YASUDA, BLAIR V. JOURNIGAN, PANKAJ R. DAGA, ; FAMING JIANG, AND CRIS OLSEN ; NOVEL ASSAYS AND CONCEPTS ; 9. MU, DELTA AND KAPPA OPIOID AGONIST EFFECTS IN NOVEL ASSAYS OF ; PAIN-DEPRESSED BEHAVIOR ; S. STEVENS NEGUS AND AHMAD A. ALTARIFI ; 10. FUNCTIONALLY BIASED AGONISM OF MU AND KAPPA OPIOID RECEPTORS ; DONALD J. KYLE ; PHARMACOLOGY OF CLASSICAL OPIOID RECEPTORS ; 11. PERIPHERALLY RESTRICTED OPIOID ANALGESICS ; PATRICK J. LITTLE ; 12. THE DELTA OPIOID RECEPTOR ; A. M. SYMONS-LIGUORI AND T. W. VANDERAH ; 13. KAPPA OPIOIDS: PROBLEMS AND OPPORTUNITIES IN ANALGESIA ; EDUARDO R. BUTELMAN AND MARY JEANNE KREEK ; 14. MIXED MU/KAPPA OPIOID AGONISTS ; JEAN M. BIDLACK AND BRIAN I. KNAPP ; PHARMACOLOGY OF NOP RECEPTORS ; 15. MEDICINAL CHEMISTRY, PHARMACOLOGY, AND BIOLOGICAL ACTIONS OF PEPTIDE ; LIGANDS SELECTIVE FOR THE NOCICEPTIN/ORPHANIN FQ RECEPTOR ; GIROLAMO CALO>' AND REMO GUERRINI ; 16. A REVIEW OF THE NOP (ORL-1)-NOCICEPTIN/ORPHANIN FQ SYSTEM COVERING ; RECEPTOR STRUCTURE, DISTRIBUTION, ROLE IN ANALGESIA AND REWARD AND ; INTERACTIONS WITH OTHER RECEPTORS ; GARTH T. WHITESIDE AND DONALD J. KYLE ; 17. PHARMACOLOGY OF MIXED NOP/MU LIGANDS ; LAWRENCE TOLL, TALINE V. KHROYAN, WILLMA E. POLGAR, STEPHEN M. HUSBANDS, AND ; NURULAIN T. ZAVERI ; 18. PHARMACOLOGICAL INVESTIGATION OF NOP-RELATED LIGANDS AS ANALGESICS ; WITHOUT ABUSE LIABILITY ; DEVKI SUKHTANKAR AND MEI-CHUAN KO ; EDITORS' BIOGRAPHIES ; INDEXES ; AUTHOR INDEX ; SUBJECT INDEX