Reference Materials in Measurement and Technology: Proceedings of the Fifth International Scientific Conference RMMT 2022

Contents
Reference Materials in the Healthcare and Pharmaceutical Industries
Certified Reference Material of Tylosin Tartrate
	Introduction
	Materials and Methods
		Reagents, Solutions, and Materials
		Instruments and Conditions
		Sample Preparation of the RM Source Substance
		Sample Analysis by IR Spectroscopy
		HPLC Sample Analysis
		Establishment of Metrological Characteristics of the Candidate RM
	Results and Discussion
		Determination of the Certified Value of the RM and Evaluation of the Standard Uncertainty from the Method of Determining the Certified Value
		RM Uniformity Study
		RM Stability Study
		RM Metrological Characteristics
	Conclusion
	References
Virus-Like Particles: Properties and Characteristics of Reference Materials
	Introduction
	Analytical Review
	Requirements for the Characteristics of CRMs for Virus-Like Particles
	Materials and Methods
		Determining the CRM Purity Mass Balance
		Amino Acid Analysis with Isotopic Dilution
	Results and Discussion
	Conclusion
	References
Reference Materials for the Composition of Antimicrobial Substances
	Introduction
	Terminology
	Materials and Methods
	Results and Discussion
	Conclusion
	References
Nominal Reference Materials of Biological Substances
	Introduction
	Theoretical Analysis
	Materials and Methods
		Type Approval Procedure in Case of Readily (Commercially) Available Source Material: On the Example of GSO 11607-2020
		Type Approval Procedure in the Absence of a Readily (Commercially) Available Source Material: On the Example of GSO 11661-2020
	Results and Discussion
	Conclusion
	References
Caffeine Quantification Via High-Precision Coulometric Titration
	Introduction
	Materials and Methods
		CRM Material
		Reagents
		Equipment
	Caffeine Identification
	Coulometric Titration Procedure
	Results and Discussion
	Uncertainty Budget
	Conclusion
	References
Primary Reference Procedure for Measuring the Mass Fraction and Molar Concentration of Copper and Zinc in Biological Materials by Isotope Dilution Mass Spectrometry
	Introduction
	Materials and Methods
		Measurement Method
		Equipment and Materials
		Research Object
	Results and Discussion
		Selection of Optimal Methodological Decisions
		Confirmation of Highest Accuracy
	Conclusion
	References
Molecular Diagnostics of Oncological Disease: Prospects for the Development of a Reference Material for the HER2 Gene Content
	Introduction
	Materials and Methods
	Results and Discussion
	Conclusion
	References
Application of Reference Materials in the Analysis of Medicinal Plant Raw Materials and Herbal Medicinal Products
	Introduction
	Materials and Methods
	Results and Discussion
	Conclusion
	References
Reference Materials in the Field of Quality of Life
Determination of Sunflower Seed Oil Content Using Natural Sunflower Oil: Calibration of a Pulsed NMR Analyzer
	Introduction
	Materials and Methods
	Results and Discussion
	Conclusion
	References
Measurement of Carbon Isotope Ratio in Vanillin Using the CM-CRDS Method: Achieving an Expanded Uncertainty Below 0.1‰
	Introduction
	Materials and Methods
		Equipment Preparation
		Sample and Reference Material Preparation
		Measurements
		Data Processing
		Measurement Accuracy Control
	Results and Discussion
	Conclusion
	References
Development of Isotopic Reference Materials for 13C-Urea Breath Tests
	Introduction
	Materials and Methods
	Results and Discussion
	Conclusion
	References
On Developing Metrological Assurance to Identify and Quantify the Content of Non-infectious Food Protein Allergens of Animal or Plant Origin in Food Products
	Introduction
	Materials and Methods
		Description of the Enzyme-Linked Immunosorbent Assay (ELISA)
		The Certification Procedure of Measurement Techniques
	Results and Discussion
	Conclusion
	References
Measurement Techniques for the Composition of Air Environments: Development and Application
	Introduction
	Reasons for the Development of New Techniques for Measuring the Composition of Air Environments
	Methodology for Developing Measurement Techniques
		Selection of Measurement Objects and Measurable Indicators
		Analysis of Measurement Techniques (Existing or Previously Valid) for Selected Objects and Indicators
		Selection of Measurement Techniques and Procedures
		Selection of the Names of the Components to Be Determined
		Establishing the Necessary Measurement Ranges of the Components to Be Determined
		Establishing a Procedure for the Analytical Sampling Stage
		Establishing a Procedure for the Methodological Analytical Stage
		Establishing a Measurement Procedure for an Analytical Sample
		Establishing the Accuracy Indicators of the Measurement Technique
		Specifying Accuracy Algorithms for Measurement Results
		Determining the Form of Presenting the Measurement Results
		Forming a Measurement Technique Document
	Technique Characterization
	Implementation and Application of Techniques
	Development and Application of CRMs Adequate for Analytical Samples
	Practical Implementation of the Proposed Methodology
	Conclusion
	References
Primary Reference Measurement Procedures in the Food Industry: Usage Experience and Development Prospects
	Introduction
	Materials and Methods
	Results and Discussion
	Conclusion
	References
Bismuth Determination by Controlled-Potential Coulometry: Developing a Highly Accurate Procedure Based on GET 176
	Introduction
	Materials and Methods
		Materials
		Methods
	Results and Discussion
	Conclusion
	References
Reference Materials of the Oil Refining, Gas, and Fuel Industry
Use of Reference Materials-Imitators for Metrological Support of Gas Analytical Measuring Instruments
	Introduction
	Theoretical Analysis
	Mathematical Approaches
	Results and Discussion
	Conclusion
	References
Prospects for the Development of Reference Materials of the Wobbe Index
	Introduction
	Materials and Methods
		Selection of a Method for Determining Gas Density
		Practical Justification and Testing of the Pycnometer Method for Determining Gas Density
	Results and Discussion
	Conclusion
	References
Reference Materials for Physical Properties
Melting Point Certified Reference Materials for Organic Substances: Development Prospects
	Introduction
	Materials and Methods
	Results and Discussion
	Conclusion
	References
Application of the Traceability Concept in Determining the Mechanical Properties of Metals Under Static Tension Using a GSO 11854-2021 Reference Material
	Introduction
	Materials and Methods
	Results
	Discussion
	Conclusion
	References
Metrological Support for Titration Isothermal Calorimetry: Prospects for the Development of Certified Reference Materials
	Introduction
	Materials and Methods
		Project Design
		Equipment
		CRM Candidate Materials
	Results and Discussion
		Defining Target Uncertainty
		Methods and Instruments for Studying Uniformity and Stability
		Testing the Method of CRM Characterization
	Conclusion
	References
Study of Certified Reference Materials for Temperature and Specific Enthalpy of Phase Transitions of Metals and Metal Salts
	Introduction
		Theoretical Background
	Materials and Methods
		Reagents
		Equipment
		Research Methods and Procedure
	Results and Discussion
	Conclusion
	References
Development of Reference Materials for AC Magnetic Properties of Cold-Rolled Non-oriented Electrical Steel
	Introduction
	Materials and Methods
		Determination of Metrological Characteristics
	Results and Discussion
	Conclusion
	References
Certified Reference Materials for the Phase Transition Temperature of Organic Substances Based on Anhydrous Sodium Acetate and Sodium Methansulfonate
	Introduction
	Materials and Methods
		Reagents
		Equipment
		Research Methods and Procedure
	Results and Discussion
	Conclusion
	References
Certified Reference Materials for the Phase Transition Temperature (Curie Temperature) Based on Alumel, Nickel, and Iron Silicide
	Introduction
	Materials and Methods
		Reagents
		Equipment
		Research Methods and Procedure
	Results and Discussion
	Conclusion
	References
Reference Materials of Absorbed Dose: Expanding Dynamic Range and Improving Measurement Accuracy
	Introduction
		Theoretical Background
	Materials and Methods
		Preparation of Film Samples-Blanks
		Selection of Films by the Value of the Initial Optical Density
		Irradiation Facilities of the State Standard GET 209-2014 with Radionuclide Sources
		Means for Measuring Optical Density
	Results and Discussion
		Dependence of the Induced Optical Density of the Selected Sets of Films on the Absorbed Dose
	Discussion and Conclusions
	References
Development of Measures for Metrological Support of Raman Spectroscopy
	Introduction
	Materials and Methods
		Materials
		Apparatuses and Laboratory Ware
		Glass Synthesis
		Determination of Metrological Characteristics and Estimation of Expanded Uncertainty
	Results and Discussion
	Conclusion
	References
Estimation of Uncertainty in Charpy Pendulum Impact Test Using the Reference Material
	Introduction
	Materials and Methods
	Results
	Discussion
	Conclusion
	References
Mathematical Methods for Characterization of Reference Materials and Risks of False Solutions
New Algorithms for Estimating the Certified Characteristic of CRMs for Substances and Materials Using Interlaboratory Certification
	Introduction
		Description of Algorithms for Processing the Results of Interlaboratory Experiments
	Results
	Conclusion
	References
On the Stability Assessment of Reference Materials
	Introduction
	Comparative Analysis
	Selecting the Number of Dimensions
	Estimation of Regression Parameters
		RM Stability Characteristics
	Period of Stability Research
	Standard Uncertainty from Instability
	Conclusion
	Appendix 1: Determination of Inequality (2)
	Appendix 2: Quadratic Equation for Determining the RM Period of Validity
	Appendix 3
	References
Algorithms for Evaluating the Homogeneity of Reference Materials for the Composition and Properties of Dispersed and Monolithic Materials
	Introduction
	Theoretical Part
		Evaluation of Dispersed Media Homogeneity
		Homogeneity Evaluation of Monolithic Materials
	Experimental
		Let Us Consider Several Typical Examples When Evaluating the Heterogeneity of Dispersed Materials
		Let Us Consider a Typical Example When Evaluating the Heterogeneity of Monolithic Materials
	Conclusion
	References
A Comparative Analysis of OIML Documents and Russian Rules on the Use of Reference Materials
	Introduction
	How to Determine Whether the RMs Used Are Within the Scope of State Control and Supervision
	Necessary Criteria for the Compliance of a CRM with the Requirements
	CRM Metrological Control
	Conclusion
	References