Receptor binding in drug research

Cover......Page 1
Half Title......Page 2
Series Page......Page 3
Title Page......Page 4
Copyright Page......Page 5
Dedication Page......Page 6
Series Introduction......Page 10
Foreword......Page 12
Preface......Page 14
Contents......Page 16
Contributors......Page 20
Part I Analysis and Interpretation of Receptor Screening Data......Page 26
 1 Receptor Binding Methodology and Analysis......Page 28
 2 Computer Analysis of Binding Data......Page 56
Part II Receptor Screening Applied to Specific Therapeutic Areas......Page 76
 3 Benzodiazepines and Nonbenzodiazepines......Page 78
 4 Enhancers of Benzodiazepine Binding......Page 102
 5 Convulsant and Anticonvulsant Drug Receptor Binding......Page 118
 6 Neuroleptic Receptor Binding in Drug Research......Page 148
 7 Receptor Binding and Atypical Antidepressant Drug Discovery......Page 176
 8 Central Recognition Sites for Psychomotor Stimulants: Methylphenidate and Amphetamine......Page 192
 9 Opiate Receptor Binding in Drug Research......Page 208
Part III Receptor Interactions with Implications in Multiple Therapeutic Areas......Page 228
 10 Molecular Heterogeneity of Leukotriene Receptors......Page 230
 11 Purinergic Receptors in Mammalian Tissue......Page 260
 12 New Routine Methodology to Study Steroid Hormone Binding Sites in Heterogeneous Tissues......Page 286
 13 Application of Ligand Binding to the Development of New Calcium Antagonists and Activators......Page 308
 14 Muscarinic Cholinergic Receptor Binding......Page 322
Part IV Receptor Applications to Peptides, Grow th Factors, and Endogenous Ligands......Page 346
 15 Interferon Receptors: Progress and Prospects......Page 348
 16 The Platelet-Derived Growth Factor Receptor......Page 362
 17 Receptor Screening Assays for Insulin and Other Growth Factors......Page 376
 18 Cholecystokinin Receptor Binding: Its Use in Drug Research and Development......Page 404
 19 Using Radioreceptor Binding Assays to Identify Endogenous Ligands......Page 418
Part V In Vivo and In Vitro Receptor Methodologies for Use in Drug Discovery and Characterization......Page 432
  20 In Vivo Receptor Modifications as a Measure of Antidepressant Potential......Page 434
  21 Antidepressant Interactions with Neurotransmitter Receptors in Vitro: Prediction of Potential Side Effects......Page 454
  22 Altered Responsiveness of the Noradrenergic-Coupled Adenylate Cyclase System in Brain......Page 474
  23 Quantitative Autoradiography in Drug Research: Tricyclic Antidepressants......Page 502
  24 Characterization of Agonist and Antagonist Interactions at the Benzodiazepine Receptor......Page 512
  25 Receptor Binding Assays for Muscarinic Cholinergic Agonists......Page 522
Index......Page 536