Recent Developments in Mass Spectrometry in Biochemistry and Medicine: Volume 1

Front Matter....Pages i-xii
Newer Aspects of the Biotransformation of Carbamazepine: Structural Characterization of Highly Polar Metabolites....Pages 1-14
Distribution in Brain Areas of Carbamazepine and Carbamazepine-10,11-epoxide in 6-Hydroxydopamine Pretreated Rats....Pages 15-28
Specific Ion Detection of Aryloxy Beta Blocking Drugs for Metabolic Fate Determinations-Applications to Alprenolol in Rats and Dogs....Pages 29-47
The Use of GC-MS in Perinatal Pharmacology: The Metabolism and Pharmacokinetics of Analgesic Drugs in Mothers and Their Babies....Pages 49-64
Studies on the Measurement of α-Methyldopa in Pregnant Women and the Newborn Infant....Pages 65-82
Gas Chromatography-Mass Spectrometry Identification of Some Urinary Metabolites of Thiopropamine,A New Antiulcer Agent....Pages 83-98
Metabolism and Pharmacokinetics of Bromopride in Rat and Man....Pages 99-112
GC and MS in the Identification of Metabolites of 5-(1-methylethyl)-1-methyl-2-nitro-l H -imidazole in Dogs....Pages 113-125
Isolation and Identification of Oxidized Metabolites of Phenazopyridine from Rat Urine....Pages 127-132
The GC-MS Analysis of Unchanged Suloctidil (sulocton (R)) in Plasma and Urine....Pages 133-142
Direct Quantification of Apovincaminic Acid Ethyl Ester (cavinton (R)) in Human Plasma and Urine by Mass Fragmentography....Pages 143-151
A Mass Fragmentographic Method for the Determination of Mescaline in Biological Fluids....Pages 153-159
Comparative in vivo Metabolism of Δ 1 -tetrahydrocannabinol (Δ 1 -THC), cannabidiol (CBD) and cannabinol (CBN) by Several Species....Pages 161-184
Chemical Ionization Techniques for the Analysis of Labile Compounds: 1,3-bis-(2-chloroethyl)-1-nitrosourea Plasma Clearance and Degradation....Pages 185-189
Metabolic Profile of Biological Constituents: (1) The Effects of Sodium Dipropylacetate on Human Urinary Acids....Pages 191-202
Investigation of Unusual Metabolites in the Urine of a Patient with Propionic Acidemia....Pages 203-216
Identification and Quantification of Gamma-Aminobutyric Acid in Human Cerebrospinal Fluid by Gas Chromatography- Mass Spectrometry....Pages 217-227
A New Derivatization Approach for the Determination of Prostaglandin A 1 by Mass Fragmentography....Pages 229-241
The Use of Stable Oxygen Isotopes and Mass Fragmentography for Assessing Enzyme Activity: Phenylalanine Hydroxylase in vivo ....Pages 243-251
Brain Monoamines, Monoamine Metabolites and Enzymes in Physiological Ageing and Senile Dementia....Pages 253-267
Ontogenic Variation of Dopamine and Norepinephrine in the Adrenal Medulla of Developing Rat. A Study by Mass Fragmentography....Pages 269-279
Quantitation of Total Urinary N -Acetylcysteine Conjugates (Mercapturic Acids) by Selected Ion Monitoring....Pages 281-289
Quantitative Analysis of Blood Amino Acids and Fatty Acids by Direct Mass Spectrometry....Pages 291-296
Blood Levels of Cadaverine and its Metabolites Monoacetylcadaverine and Monopropionylcadaverine in Psychotic Subgroups of Schizophrenics....Pages 297-319
Quantitative Analysis of Free and Bound Cholesterol and Cholesterol Ester Fatty Acids in Blood by Direct Mass Spectrometry....Pages 321-326
New Developments in the Field of Mass Spectrometry and GC-MS and Their Applications to Toxicological Analysis....Pages 327-341
 In situ Methylation and/or FD-MS: A Comparative Study of Their Usefulness in the Structure Analysis of Highly Polar Metabolites....Pages 343-352
The Exchange of Trideuteromethyl Groups when Using Methane as a Reagent Gas in Chemical Ionisation Mass Spectrometry....Pages 353-360
Controlled Thermal Degradation Mass Spectrometry. A Direct Approach for the Analysis of Biological and Synthetic Polymers....Pages 361-370
Comparison of Library Search Methods with Binary Encoded Steroid Mass Spectra....Pages 371-378
Fragmentation of Monosubstituted Cyclopentenes Under Electron Impact Mass Spectrometry....Pages 379-393
Mass Spectrometric Investigations of Stereoisomeric 3-Substituted Tropane Derivatives....Pages 395-404
Cyclic Alkoxythiobenzamides. Mass Fragmentation and Rearrangement Under Electron Impact....Pages 405-416
Fragmentation of Piperazinodibenzazepines on Electron-Impact....Pages 417-428
Isolation and Determination of Structures of Some New Diterpenoid Alkaloids in Delphinium ajacis by Mass Spectrometry....Pages 429-439
Mass Spectrometric Studies of Algal Sterols Using an Open Tubular Capillary Column....Pages 441-456
Open Tubular Capillary Column Gas Chromatography-Mass Spectrometry of Cholecalciferol and Its Active Metabolites....Pages 457-470
Mass Spectral Fragmentation of C 5 -Substituted Barbituric Acid Derivatives....Pages 471-482
The Mass Spectra of Permethylated Disaccharides....Pages 483-491
Quantitative Determination of Unconjugated Pterins in Biological Extracts by Gas Chromatography-Mass Fragmentography....Pages 493-501
Mass Spectrometry of Sialic Acids....Pages 503-520
Direct Evidence of Epoxide Metabolic Pathway for Natural Allylbenzene Compounds in Adult Rat Liver Cell Culture....Pages 521-539
Identification and Quantitative Determination of 2,3,7,8-Tetrachlorodibenzo- para -Dioxin in Animals From a Contaminated Area....Pages 541-547
Structure Elucidation of Hydroxylated Metabolites of Polychlorinated Aromatic Compounds by GC-MS Investigation of Their Methyl Ethers....Pages 549-553
Detection of Polychlorodibenzodioxins in Fly Ash and Flue Gas of Municipal Incinerators....Pages 555-562
2,3,7,8 TCDD Monitoring in Flue Gases from an Incinerating Plant....Pages 563-568
A Peripherally Inserted Flow Directed Catheter for Use in Continuously Monitoring Pulmonary Artery Oxygen and Carbon Dioxide Tensions....Pages 569-576
The Effect of Acute Alkalosis on Intrahepatic Oxygen Tension as Measured in Bile....Pages 577-586
Medical Mass Spectrometry in Simultaneous Measurement of Respiratory and Blood Gases....Pages 587-593
Measurements of Whole Body Protein Turnover in Man with 15 N-glycine....Pages 595-604
 15 N Abundance in N-Fixing and Non-N-Fixing Plants....Pages 605-622
Isotope Effects in Metabolic Studies....Pages 623-640
Back Matter....Pages 641-658