Radiation Carcinogenesis and DNA Alterations

Front Matter....Pages i-xi
Follow-up Studies of Patients Treated by X-Ray Epilation for Tinea Capitis....Pages 1-25
Tumour Induction in Experimental Animals after Neutron and X-Irradiation....Pages 27-50
Dose-Response for Radiation-Induced Cancer in Rat Skin....Pages 51-70
Experimental Radiation Carcinogenesis....Pages 71-105
Radiation Carcinogenesis and the Hair Follicle....Pages 107-114
Dose-Incidence Relations for Radiation Carcinogenesis with Particular Reference to the Effects of High-Let Radiation....Pages 115-137
Assessment of the Lung Cancer Risk from Radiation Exposures Due to Airtightening of Dwellings for Energy Conservation....Pages 139-145
Carcinogenic Effects of Inhaled Radionuclides....Pages 147-154
Mechanisms of Radiation Transformation....Pages 155-162
The Radiobiology of In Vitro Neoplastic Transformation....Pages 163-184
Induction of Chromosome Aberrations and Malignant Transformation in Different Cell Lines by Photons and Monoenergetic Neutrons....Pages 185-207
Radiation Induced Transformation in Primary Differentiated Thyroid Cultures....Pages 209-216
The Induction and Repair of Ultraviolet Light Damage in Mammalian Cells....Pages 217-231
Alterations in Benzo(a)Pyrene Metabolism and its DNA Adduct Formation in Skin of Mice Chronically Exposed to Ultraviolet-B Radiation....Pages 233-241
Immunosuppression by Ultraviolet Radiation; Possible Role of Cis-urocanic Acid, a Product of UV Irradiation....Pages 243-244
DNA Damage and Chromosome Aberrations....Pages 245-264
Chromosome Break-Points, Somatic Mutation and Oncogene Activation: Some Comments....Pages 265-276
The Yield of Chromosomal Aberrations and its Correlation with Other Biological Endpoints....Pages 277-291
X-Ray-Induced DNA Double Strand Breaks in Polynucleosomes....Pages 293-296
Chemical Inhibition of the Repair of DNA Single Strand Breaks Produced by X-irradiation or Hydrogen Peroxide in Cultured Mammalian Cells....Pages 297-304
Conjugated Dienes and TBA Reactive Material as Components of Chromosome Breakage Factors....Pages 305-311
Conversion of Covalently Closed Circular DNA into Circular and Linear DNA by Ionizing Radiation in the Presence and Absence of DNA-binding or Intercalating Drugs....Pages 313-319
How Soon After Irradiation Do Chromosome Aberrations Form and Become Irreversible: a Direct Analysis by Means of the Premature Chromosome Condensation Technique....Pages 321-329
Production by Radiation of DNA Double Strand Breaks in Three Mammalian Cell Lines and their Repair in Foetal Human Fibroblasts....Pages 331-337
The Role of Oncogenes in Multistage Carcinogenesis....Pages 339-351
A Regulatory Sequence of Simian Virus 40 is Inactivated by UV-Induced Damage....Pages 353-357
Mechanisms of Spontaneous Mutagenesis: Implications for Spontaneous Carcinogenesis....Pages 359-371
A Method for the Detection of Neo-Antigens in X-ray Induced Thymomas of C57BL/6 Mouse....Pages 373-380
Visible Light Induced Killing and Mutation of Acriflavine Sensitized Chinese Hamster Cells....Pages 381-387
Oncogenes Activated in Radiation-Induced Rat Skin Tumors....Pages 389-397
Mutagenesis in Mammalian Germs Cells by Radiation or Nitrogen Mustard—A Comparative Study....Pages 399-404
Gene Amplification in Mammalian Cells after Exposure to Ionizing Radiation and UV....Pages 405-411
Regulation of Gene Expression at the Translational Level in Plant Embryo....Pages 413-421
Prooxidant States and Promotion....Pages 423-423
Molecular Aspects of DNA Damage and its Modification....Pages 425-438
5-Hydroxymethyl Uracil: A Product of Ionizing Radiation and Tritium Transmutation Formed in DNA....Pages 439-445
Characterization of Two CHO Variants in Respect to MNNG-Induced Cell Killing, Mutations, and Repair of Methylated DNA Bases....Pages 447-451
Investigation of the Sensitivity of Oriented (φX-174 DNA to Ionizing Radiation....Pages 453-466
Radiosensitizers and Thymine Base Damage....Pages 467-469
Human Cancer-Prone Disorders, Abnormal Carcinogen Response, and Defective DNA Metabolism....Pages 471-498
New DNA Repair Systems and New Insights on Old Systems in Escherichia coli ....Pages 499-509
The Relationship of Defective Recognition of DNA Damage to Cancer in Ataxia-Telangiectasia....Pages 511-515
Multifunctional Repair Enzymes Excise Thymine and Adenine Residues Damaged by Ionizing Radiation from DNA....Pages 517-521
Age and Species Specific Variation in DNA Excision Repair in Cultured Skin Fibroblasts....Pages 523-537
Non-Stochastic Effects: Compatibility with Present ICRP Recommendations....Pages 539-557
Carcinogenic Potential of Incinerated Low-Level Radioactive Waste: Cytopathologic Evaluation....Pages 559-566
Carcinogenic Potential of Incinerated Low-Level Radioactive Waste: Electrophoretic Resolution....Pages 567-571
X-rays Low Dose Relationships within the G 2 Phase of Chinese Hamster Cells....Pages 573-581
The Dependence of Dose-Effect Relations for Various Responses in Mammalian Cells on Radiation Quality, Implications for Mechanisms of Carcinogenesis....Pages 583-591
The Physics of Absorbed Dose and Linear Energy Transfer....Pages 593-609
Back Matter....Pages 611-618