Quantitative Biology of Metabolism: Models of Metabolism, Metabolic Parameters, Damage to Metabolism, Metabolic Control

Front Matter....Pages I-XVI
The Epistemological Significance of Models in Science....Pages 1-10
Causality, Complexity and Computers....Pages 11-23
Discrete and Continuous Representations of Metabolic Models....Pages 24-32
Interaction of a Digital (Genetic) System with a Continuous (Enzymatic) One in the Cell....Pages 33-37
A Model for Sustained Rhythmic Binary Logic in Biochemical Systems....Pages 38-44
Some General Ideas on Deterministic and Stochastic Models of Biological Systems....Pages 45-65
Turnover Compartmentalization. An Approach to Analysis of Whole-Body Retention Data....Pages 66-70
Functioning of a Cell Model....Pages 71-74
A Digital Computer System for the Construction and Analysis of Steady State Models of Enzyme Catalysed Networks....Pages 75-80
Computation of Equilibria and Kinetics of Chemical Systems with Many Species....Pages 81-85
The Relation between Heat Production, Oxygen Consumption and Temperature in Some Poikilotherms....Pages 86-90
On Structure and Metabolic Rate of the Skeletal Muscle of the Eel ( Anguilla vulgaris L.)....Pages 91-94
Analysis of Heart Rate Adaptation to Temperature....Pages 95-101
The Heat Production of Goldfinches and Canaries in Summer and Winter....Pages 102-105
Quantitative Thermogenesis of Brown Fat in Hibernation and Cold Adaptation....Pages 106-112
Contributions to the Energetics of Animal Growth....Pages 113-126
Models of the Growth of Organisms under Nutrient Limiting Conditions....Pages 127-132
Biomathematical Interpretation of Organismic Growth....Pages 133-135
Relationships Between Respiration During Imbibition and Subsequent Growth Rates in Germinating Seeds....Pages 136-146
Quantitative Parameters of Rat Liver Mitochondria in Relation to Age....Pages 147-150
Enzymes as Indicators of Intracellular Reaction Conditions....Pages 151-153
The Influence of Ethanol on Carbohydrate- and Fat-Metabolism of the Liver....Pages 154-156
Application of Quantitative Models for the Analysis of the Mechanisms of Protection against the Damaging Effects of Ionizing Radiation....Pages 157-163
Intracellular Recovery after Irradiation....Pages 164-176
Inhibitory Action of Radiolytic Compounds on Cell Function....Pages 177-181
On the Release and Elimination of Liver Glutamic-Oxalacetic-Transferase....Pages 182-184
Metabolic Effects of Acute Hypoxia on Rat and Turtle Brain....Pages 185-189
Changes in Metabolite Concentrations in Ischemic Kidneys of Rabbits and in Transplanted Kidneys of Dogs....Pages 190-194
Oscillatory Control of Glycolysis as a Model for Biological Timing Processes....Pages 205-216
Evaluation of the Coordinated Control of Activated Glycolysis and Respiration by Orthophosphate and ADP in Ascites Tumor Cells....Pages 217-220
Profiles of Substrate Levels of the Central Metabolic Pathways in Frog Heart....Pages 221-226
The Use of Theoretical Models in the Study of Thermoregulation in Man....Pages 262-273
On the Mechanism of the Calorigenic Action of Catecholamines....Pages 274-277
The Mutual Co-Action of two Regulatory Mechanisms Realizing Optimal Autoregulation of Metabolism....Pages 195-201
Optimization of Structure and Metabolism in Cellular Automata....Pages 202-204
Analysis by Computer of some Oscillatory Features of the Red Cell System....Pages 227-233
Memory and Cellular Control Processes....Pages 234-244
On the Steady State Nature of Evolution, Learning, Perception, Hallucination and Dreaming....Pages 245-257
Circadian Activity Rhythm in the CNS and its Control....Pages 258-261
Some Epicritical Remarks (Instead of a Summary)....Pages 278-280
Back Matter....Pages 281-296