Providing Pharmacological Access to the Brain: Alternate Approaches

Content: 
Methods in Neurosciences
Page ii

Front Matter
Page iii

Copyright page
Page iv

Contributors to Volume 21
Pages ix-xiv

Preface
Pages xv-xvi
THOMAS R. FLANAGAN, DWAINE F. EMERICH, SHELLEY R. WINN

Methods in Neurosciences
Pages xvii-xviii

1 - Cellular Response of Central Nervous System Tissue to Invasive Therapeutic Measures
Pages 3-19
Ann Logan, Martin Berry

2 - Models of Angiogenesis and the Blood–Brain Barrier
Pages 20-32
Jeffrey M. Rosenstein, Janette M. Krum

3 - Osmotic Opening of the Blood–Brain Barrier and Brain Tumor Chemotherapy
Pages 35-51
Peter J. Robinson

4 - Osmotic Blood-Brain Barrier Modification: Increasing Delivery of Diagnostic and Therapeutic Agents to the Brain
Pages 52-67
Edward A. Neuwelt, Robert A. Kroll

5 - Peripheral Administration of Nerve Growth Factor Conjugated to an Anti-transferrin Receptor Antibody Increases Cholinergic Neuron Survival in Intraocular Forebrain Transplants
Pages 71-92
Ann-Charlotte Granholm, Paul T. Biddle, Cristina Bäckman, Ted Ebendal, Greg Gerhardt, Barry Hoffer, Ludmila Mackerlova, Lars Olson, Stine Söderström, Lee Walus, Phillip Friden

6 - Ferrotransferrin and Antibody against the Transferrin Receptor as Potential Vehicles for Drug Delivery across the Mammalian Blood–Brain Barrier into the Central Nervous System
Pages 93-117
Richard D. Broadwell, Belinda J. Baker, William A. Banks, Phillip Friden, Marjorie Moran, Constance Oliver, Juan C. Villegas

7 - DepoFoam-Mediated Drug Delivery into Cerebrospinal Fluid
Pages 118-131
Sinil Kim

8 - Interstitial Drug Delivery to the Central Nervous System Using Controlled Release Polymers: Chemotherapy for Brain Tumors
Pages 135-149
Rafael J. Tamargo, Robert Langer, Henry Brem

9 - Sustained Intracerebral Delivery of Nerve Growth Factor with Biodegradable Polymer Microspheres
Pages 150-168
Alejandro Mendez, Paul J. Camarata, Raj Suryanarayanan, Timothy J. Ebner

10 - Polymeric Drug Carrier Systems in the Brain
Pages 169-183
Abraham J. Domb, Israel Ringel

11 - Using Osmotic Minipumps for Intracranial Delivery of Amino Acids and Peptides
Pages 187-200
Jeffrey D. White, Michael W. Schwartz

12 - Continuous Central Nervous System Infusion with Alzet Osmotic Pumps
Pages 201-213
Theo Hagg

13 - Injection of Biologically Active Substances into the Brain
Pages 214-234
Paul M. Carvey, Terrence J. Maag, Donghui Lin

14 - Factors Important in the Survival of Dopamine Neurons in Intracerebral Grafts of Embryonic Substantia Nigra
Pages 237-252
Roger Barker, Rosemary Fricker, Stephen B. Dunnett

15 - Techniques in Adrenal Medullary Transplantation for Experimental Nonhuman Primate Parkinsonism
Pages 253-271
Massimo S. Fiandaca, Jeffrey H. Kordower

16 - Technical Aspects of Transplantation of the Adrenal Medulla to the Caudate Nucleus as a Treatment for Parkinson's Disease
Pages 272-277
Stephen W. Carmichael, Susan L. Stoddard, Patrick J. Kelly

17 - Transplantation of Epidermal Growth Factor-Responsive Neural Stem Cell Progeny into the Murine Central Nervous System
Pages 281-293
Joseph P. Hammang, Brent A. Reynolds, Samuel Weiss, Albee Messing, Ian D. Duncan

18 - Application of Astrocyte Transplants as a Therapeutic Intervention
Pages 294-307
J. Patrick Kesslak, Richard J. Bridges

19 - Development of Immortalized Cell Lines for Transplantation in Central Nervous System Injury and Degeneration Models
Pages 308-325
M. Giordano, H. Takashima, M. Poltorak, H.M. Geller, W.J. Freed

20 - Use of Genetically Modified Cells to Deliver Neurotrophic Factors and Neurotransmitters to the Brain
Pages 329-347
Lisa J. Fisher, Gordon R. Chalmers, Fred H. Gage

21 - Neuropeptide and Catecholamine Delivery to Central Nervous System by Implanted Chromaffin Cells
Pages 348-368
Jacqueline Sagen, John D. Ortega, George D. Pappas

22 - Microencapsulation of Cells in Thermoplastic Copolymer (Hydroxyethyl Methacrylate–Methyl Methacrylate)
Pages 371-386
M.V. Sefton, H. Uludag, J. Babensee, T. Roberts, V. Horvath, U. De Boni

23 - Hydrogel Applications for Encapsulated Cellular Transplants
Pages 387-392,392a,393-402
Shelley R. Winn, Patrick A. Tresco

24 - Tests for Validating the Safety of Encapsulated Xenografts
Pages 403-423
T.R. Flanagan, B. Frydel, B. Tente, M. Lavoie, E. Doherty, D. Rein, D.F. Emerich, S.R. Winn

25 - Particle Bombardment for Gene Transfer into Nerve Cell Systems
Pages 427-432,432a,433-440
Ning-Sun Yang, Shoushu Jiao, Carolyn De Luna

26 - A Defective Herpes Simplex Virus Vector System for Genetic Intervention in the Adult Brain: Applications to Gene Therapy and Neuronal Physiology
Pages 443-461
Alfred I. Geller, Mathew J. During, Rachael Neve

27 - Expression of Neurotrophic Genes from Herpes Simplex Virus Type 1 Vectors: Modifying Neuronal Phenotype
Pages 462-482
Michael D. Geschwind, Bing Lu, Howard J. Federoff

28 - Assessing Commercial Potential of Central Nervous System Delivery Approaches
Pages 485-498
John S. Swen, Thomas R. Flanagan, Thomas G. Wiggans

Index
Pages 499-508