Proteomic and Metabolomic Approaches to Biomarker Discovery

Content: 
Front Matter, Page iii
Copyright, Page iv
Preface, Pages xi-xii, Haleem J. Issaq, Timothy D. Veenstra
List of Contributors, Pages xiii-xv, Karen S. Anderson, Thorkell Andresson, Ihor Batruch, Josip Blonder, Julien Boccard, Egisto Boschetti, Allen D. Bosley, Dean E. Brenner, Giovanni Candiano, Joe R. Cannon, Richard M. Caprioli, Mary Joan Castillo, King C. Chan, Wonryeon Cho, Sudipto Das, Eleftherios P. Diamandis, Danijel Djukovic, Andrei P. Drabovich, Virginia Espina, Catherine Fenselau,  et al.
Chapter 1 - Biomarker Discovery: Study Design and Execution, Pages 1-16, Haleem J. Issaq, Timothy D. Veenstra
Chapter 2 - Proteomic and Mass Spectrometry Technologies for Biomarker Discovery, Pages 17-37, Andrei P. Drabovich, Maria P. Pavlou, Ihor Batruch, Eleftherios P. Diamandis
Chapter 3 - Tissue Sample Preparation for Proteomic Analysis, Pages 39-50, Xiaoying Ye, DaRue A. Prieto, King C. Chan, Bih-Rong Wei, Josip Blonder
Chapter 4 - Sample Preparation in Global Metabolomics of Biological Fluids and Tissues, Pages 51-75, Dajana Vuckovic
Chapter 5 - Serum and Plasma Collection: Preanalytical Variables and Standard Operating Procedures in Biomarker Research, Pages 77-85, Melissa Tuck, D. Kim Turgeon, Dean E. Brenner
Chapter 6 - Current NMR Strategies for Biomarker Discovery, Pages 87-117, Que N. Van
Chapter 7 - Using Data-Independent Mass Spectrometry to Extend Detectable Dynamic Range without Prior Fractionation, Pages 119-130, Young Ah Goo, David R. Goodlett
Chapter 8 - Gas Chromatography/Mass Spectrometry-Based Metabonomics, Pages 131-144, Lian Yee Yip, Eric Chun Yong Chan
Chapter 9 - Liquid Chromatographic Methods Combined with Mass Spectrometry in Metabolomics, Pages 145-161, Georgios A. Theodoridis, Helen G. Gika, Robert Plumb, Ian D. Wilson
Chapter 10 - Capillary Electrophoresis–Mass Spectrometry for Proteomic and Metabolic Analysis, Pages 163-173, Chenchen Wang, Cheng S. Lee
Chapter 11 - Current Gel Electrophoresis Approaches to Low-Abundance Protein Marker Discovery, Pages 175-190, Egisto Boschetti, Giovanni Candiano, Pier Giorgio Righetti
Chapter 12 - Two-Dimensional Difference in Gel Electrophoresis for Biomarker Discovery, Pages 191-195, Haleem J. Issaq, Timothy D. Veenstra
Chapter 13 - Affinity Targeting Schemes for Biomarker Research, Pages 197-224, Fred E. Regnier, Wonryeon Cho
Chapter 14 - Asp-Selective Microwave-Supported Acid Proteolysis, Pages 225-236, Joe R. Cannon, Catherine Fenselau
Chapter 15 - Sample Depletion, Fractionation, and Enrichment for Biomarker Discovery, Pages 237-244, Haleem J. Issaq, Timothy D. Veenstra
Chapter 16 - Protein and Metabolite Identification, Pages 245-258, Timothy D. Veenstra, Que N. Van, Stephen D. Fox, Haleem J. Issaq
Chapter 17 - Quantitative Proteomics in Development of Disease Protein Biomarkers, Pages 259-278, Xudong Yao, Adam J. McShane, Mary Joan Castillo
Chapter 18 - Mass Spectrometry and NMR Spectroscopy–Based Quantitative Metabolomics, Pages 279-297, Danijel Djukovic, G.A. Nagana Gowda, Daniel Raftery
Chapter 19 - Multivariate Analysis for Metabolomics and Proteomics Data, Pages 299-311, Frederick H. Long
Chapter 20 - Top-Down Mass Spectrometry for Protein Molecular Diagnostics and Biomarker Discovery, Pages 313-332, Steven M. Patrie, Michael J. Roth, Junmei Zhang
Chapter 21 - A Role for Protein–Protein Interaction Networks in the Identification and Characterization of Potential Biomarkers, Pages 333-347, Allen D. Bosley, Sudipto Das, Thorkell Andresson
Chapter 22 - Reverse Phase Protein Microarray Technology: Advances into the Clinical Research Arena, Pages 349-361, Emanuel F. Petricoin III, Brian Leyland-Jones, Julie Wulfkuhle, Marielena Pierobon, Claudius Mueller, Virginia Espina, Lance A. Liotta
Chapter 23 - Autoantibodies and Biomarker Discovery, Pages 363-378, Ji Qiu, Karen S. Anderson
Chapter 24 - MicroRNAs and Biomarker Discovery, Pages 379-392, Hans-Martin Jäck, Jürgen Wittmann
Chapter 25 - Imaging Mass Spectrometry of Intact Biomolecules in Tissue Sections, Pages 393-406, Erin H. Seeley, Richard M. Caprioli
Chapter 26 - Mass Spectrometry–Based Approach for Protein Biomarker Verification, Pages 407-424, Zhaojing Meng, Timothy D. Veenstra
Chapter 27 - Mass Spectrometry Metabolomic Data Handling for Biomarker Discovery, Pages 425-445, Julien Boccard, Serge Rudaz
Chapter 28 - Analytical Methods and Biomarker Validation, Pages 447-450, Haleem J. Issaq, Timothy D. Veenstra
Index, Pages 451-472