Proteolysis in the Interstitial Space

Content: Cover 
 Half Title 
 Title Page
 Copyright Page
 Dedication 
 Table of Contents 
 Preface 
 Acknowledgments 
 Authors 
 Chapter 1: Composition and Function of the Interstitial Fluid
 1.1 Definition of Interstitial Fluid 
 1.2 Extravasation 
 1.3 Cell Secretion in Interstitial Space 
 1.4 Connectivity of Interstitial Fluid and Other Extravascular Fluids 1.5 Relationship of Interstitial Fluid to Lymph 1.6 Structure of Interstitium 
 1.6.1 Heterogeneity in Interstitium 
 1.7 Methods for Obtaining Interstitial Fluid and Some Diagnostic Applications
 1.8 Transport of Drugs and Biologicals in Interstitial Fluid 
 1.8.1 Transport of Drugs in Interstitial Space 1.8.2 Transport of Biologicals in Interstitial Space 1.9 Tumor Interstitial Fluid 
 References 
 Chapter 2: The Extracellular Matrix, Basement Membrane, and Glycocalyx
 2.1 Matrices that Modulate Interstitial Fluid Composition 
 2.2 Extracellular Matrix 
 2.3 Basement Membrane 
 2.4 Glycocalyx 
 References Chapter 3: The Biochemistry of Hyaluronan in the Interstitial Space3.1 Hyaluronan 
 3.1.1 Introduction to Hyaluronan 
 3.1.2 Physical Characteristics of Hyaluronan 
 3.1.2.1 Effect of Protein on Hyaluronan Conformation
 3.1.3 Solvent and Hyaluronan 
 3.2 Hyaluronan in Interstitial Space 
 3.3 Effect of Hyaluronan on Enzyme Activity 3.4 Specific Interaction of Hyaluronan with Receptors (Hyaladherins)3.4.1 CD44 
 3.4.2 RHAMM 
 3.4.3 Other Cell Surface Receptors for Hyaluronan 
 3.4.4 Hyaluronan Binding to Other Hyaladherins 
 3.5 Low-Molecular-Weight Hyaluronan 
 3.6 Hyaluronan as a Therapeutic