Protein-Protein Interactions as New Drug Targets

Front Matter....Pages i-xv
A-Kinase Anchoring Proteins as the Basis for cAMP Signaling....Pages 3-14
Arrestins as Multi-Functional Signaling Adaptors....Pages 15-37
Role of Ena/VASP Proteins in Homeostasis and Disease....Pages 39-65
Scaffold/Matrix Attachment Regions (S/MARs): Relevance for Disease and Therapy....Pages 67-103
Clathrin/AP-2-Dependent Endocytosis: A Novel Playground for the Pharmacological Toolbox?....Pages 105-122
PDE4 Associates with Different Scaffolding Proteins: Modulating Interactions as Treatment for Certain Diseases....Pages 125-166
G-Protein-Coupled Receptor-Signaling Components in Membrane Raft and Caveolae Microdomains....Pages 167-184
Protein Scaffolds, Lipid Domains and Substrate Recognition in Protein Kinase C Function: Implications for Rational Drug Design....Pages 185-203
Compartmentalised MAPK Pathways....Pages 205-235
Dynamic Protein Complexes Regulate NF-κB Signaling....Pages 237-259
An Oncogenic Hub: β-Catenin as a Molecular Target for Cancer Therapeutics....Pages 261-284
A Toolkit for Real-Time Detection of cAMP: Insights into Compartmentalized Signaling....Pages 285-298
Scaffolding Proteins in Cardiac Myocytes....Pages 301-325
Molecular Architecture of Signal Complexes Regulating Immune Cell Function....Pages 327-363
Scaffolding Proteins at the Postsynaptic Density: Shank as the Architectural Framework....Pages 365-380
Domains Mediate Protein-Protein Interactions and Nucleate Protein Assemblies....Pages 383-405
Proline-Rich Sequence Recognition Domains (PRD): Ligands, Function and Inhibition....Pages 407-429
Chemical Inhibition Through Conformational Stabilization of Rho GTPase Effectors....Pages 431-460
Pharmacological Interference with Protein-Protein Interactions Mediated by Coiled-Coil Motifs....Pages 461-482
Direct AKAP-Mediated Protein-Protein Interactions as Potential Drug Targets....Pages 483-503
Back Matter....Pages 505-512