Protein Design and the Development of New Therapeutics and Vaccines

Front Matter....Pages i-xxii
Front Matter....Pages 1-1
Dynamic Processes in Proteins by X-Ray Diffraction....Pages 3-21
Mass Spectrometric Methods for Determination of the Structure of Peptides and Proteins....Pages 23-46
Front Matter....Pages 47-47
Protein Folding and Stability....Pages 49-57
Genetic Analysis of Polypeptide Chain Folding and Misfolding in Vivo....Pages 59-78
Unfolding and Inactivation....Pages 79-115
Front Matter....Pages 117-117
Protein—Tyrosine Kinases and Their Substrates....Pages 119-139
Front Matter....Pages 141-141
G Proteins....Pages 143-153
Model of Signal Transduction by G Proteins....Pages 155-178
Structural Homologies in G-Binding Proteins....Pages 179-206
Front Matter....Pages 207-207
Knowledge-Based Protein Modeling and the Design of Novel Molecules....Pages 209-227
Computer Simulation Methods as Applied to Site-Specific Mutations....Pages 229-236
Dihydrofolate Reductase....Pages 237-249
Front Matter....Pages 251-251
Chemical Approaches to Protein Engineering....Pages 253-282
New Engineered Proteins for Use in Therapy and Vaccine Design....Pages 283-295
Receptor-Based Design of Dihydrofolate Reductase Inhibitors....Pages 297-327
Front Matter....Pages 329-329
Control of the Biological Dispersion of Therapeutic Proteins....Pages 331-357
Antibody-Mediated Drug Delivery....Pages 359-370
Semisynthetic Catalytic Antibodies....Pages 371-394
Front Matter....Pages 395-395
Engineering Novel, Prolonged-Acting Insulins....Pages 397-422
Front Matter....Pages 423-423
Studies on the Structure and Function of Ubiquitin....Pages 425-447
Front Matter....Pages 423-423
Recognition at Membrane Surfaces Influenza HA and Human HLA....Pages 449-475
Back Matter....Pages 477-489