Prostanoids and Drugs

Front Matter....Pages i-x
Molecular Biology of Leukotriene Formation....Pages 1-4
Fundamental Mass Spectrometry and Eicosanoids Research....Pages 5-14
Quantitative Analysis of Eicosanoids by Gas Chromatography-Mass Spectrometry....Pages 15-22
Formation and Mechanism of Action of Epoxyeicosatrienoic Acids....Pages 23-29
Reactive Eicosanoid Intermediates and Transcellular Biosynthesis....Pages 31-36
Metabolism of Sulfidopeptide Leukotrienes....Pages 37-46
Lipoxins: Biosynthesis, Metabolism and Physiological Functions....Pages 47-53
Leukotrienes in the Lung and Cardiovascular System....Pages 55-64
Blood Platelets, Aspirin and Prevention of Vascular Disease....Pages 65-69
Cardioprotective Effects of Prostacyclin Analogues....Pages 71-81
New Pharmacological Agents Which Antagonize Leukotriene D 4 and Platelet Activating Factor....Pages 83-104
9 α, 11 β -Prostaglandin F 2 : A New Prostanoid, That Inhibits Platelet Aggregation and Constricts Blood Vessels....Pages 105-112
Stenosis and Vascular Damage as an Experimental Model of Arterial Thrombosis: A Role for Prostanoids....Pages 113-119
Renal and Platelet Eicosanoids in Chronic Glomerular Disease....Pages 121-136
Role of Leukotrienes in Experimental Gastric Ulceration....Pages 137-144
Role of Leukotrienes in Inflammatory Bowel Disease....Pages 145-151
Gastric Cytoprotection....Pages 153-160
Gastric Mucosal Damage by Nonsteroidal Anti-Inflammatory Drugs....Pages 161-167
Aspects of Eicosanoids in Inflammation....Pages 169-182
Modulation of the Inflammatory Potential of the 5-Lipoxygenase Pathway by Alternative Fatty Acids and Cytokines....Pages 183-193
Inhibitors of Leukotriene Action: Potential Use in Asthma, Inflammatory Bowel Disease, and Cutaneous Inflammation....Pages 195-219
Novel 5-Lipoxygenase Inhibitors in Inflammation and Asthma....Pages 221-225
Eicosanoids as Regulators of Eicosanoid Release in Macrophages: Impact for Exacerbation of Tissue Damage by Non-Steroidal Anti-Inflammatory Drugs....Pages 227-234
Eicosanoid Regulation of Macrophage-Mediated Anti-Tumor Function....Pages 235-242
Interactions between Anti-Inflammatory Drugs and Cancer Chemotherapy....Pages 243-248
Back Matter....Pages 249-260