Prostacyclin and Its Stable Analogue Iloprost

Front Matter....Pages I-XV
Front Matter....Pages 1-1
The Impact of Prostacyclin Studies on the Development of Its Stable Analogues....Pages 3-15
Chemistry of Stable Prostacyclin Analogues: Synthesis of Iloprost....Pages 17-24
Prostaglandins, Thromboxanes and Platelet Function....Pages 25-37
Effects of Iloprost on Platelet Activation In Vitro....Pages 39-45
In Vitro Effects of Iloprost on Platelet Aggregation in Normal and Hypercholesterolemia Subjects....Pages 47-51
Desensitization of Iloprost or Prostacyclin Responsiveness....Pages 53-56
Resistance of Platelets to Prostacyclin....Pages 57-63
Preliminary Comparison of the Effects of Iloprost, Prostacyclin (PGI 2 ) and Prostaglandin E 1 (PGE 1 ) on Human Platelet Function....Pages 65-68
Laboratory Investigations of Potential Heparin — Iloprost Interactions....Pages 69-79
Antithrombotic Profile of Iloprost in Experimental Models of Arterial and Venous Thrombosis....Pages 81-90
Monitoring of Effectiveness of Prostaglandin Therapy in Humans....Pages 91-96
Effect of Iloprost (ZK 36374) on White Cell Behavior....Pages 97-102
Back Matter....Pages 103-112
Front Matter....Pages 113-113
Eicosanoid Expression of Vascular Sexual Dimorphism....Pages 115-121
Profile of Generation of Eicosanoids by Blood Vessels and the Heart....Pages 123-128
Studies on Vasorelaxant Effects and Mechanisms of Iloprost in Isolated Preparations....Pages 129-137
Effects of Iloprost Treatment in the Rat on Prostacyclin Release from Isolated Aortas....Pages 139-142
Electrical and Mechanical Effects of Prostacyclin in the Canine Carotid Artery....Pages 143-149
Hemodynamic Profile of Iloprost in Rats, Rabbits and Cats....Pages 151-158
Actions of Prostaglandins on the Heart....Pages 159-178
Myocardial Ischemia: The Potential Therapeutic Role of Prostacyclin and Its Analogues....Pages 179-194
Back Matter....Pages 279-286
Front Matter....Pages 113-113
Effects of Iloprost on Arrhythmias and Infarct Size in Rats After Coronary Artery Ligation....Pages 195-204
The Protective Mechanism of Iloprost in Several Models of Jeopardizing Ischemia in the Myocardium....Pages 205-214
Evolution Toward Necrosis During Intermittent Periods of Myocardial Ischemia: Cytoprotective Effects of Iloprost, a Stable Prostacyclin Analogue....Pages 215-229
Protective Effects of Iloprost Against Thromboxane-Induced Myocardial Infarction....Pages 231-242
Allograft Survival with Iloprost....Pages 243-246
Iloprost in Experimental Cerebral Ischemia....Pages 247-255
Cytoprotective Effect of Iloprost Against Liver Cell Death Induced by Carbon Tetrachloride (CCl 4 ) or Bromobenzene....Pages 257-268
Lipofundin Arteriosclerosis and Iloprost Treatment....Pages 269-278
Back Matter....Pages 279-286
Front Matter....Pages 287-287
Iloprost and Thrombosis Prevention....Pages 289-291
Prostacyclin and Iloprost — Thrombosis and Atherosclerosis....Pages 293-294
The Reduction of Ultimate Infarct Size: State of the Art and Goals for the Future....Pages 295-298
Iloprost and Cytoprotection....Pages 299-299
Cardioprotective Effects of Iloprost....Pages 301-303
Back Matter....Pages 305-314