Progress in Neutron Capture Therapy for Cancer

Front Matter....Pages i-xxxi
An Optimized Epithermal Neutron Beam for Neutron Capture Therapy (NCT) at the Brookhaven Medical Research Reactor (BMRR)....Pages 1-6
The Petten BNCT Project....Pages 7-12
The Idaho Power Burst Facility/Boron Neutron Capture Therapy (PBF/BNCT) Program Overview....Pages 13-20
The Neutron Capture Therapy Research Program at New England Medical Center and the Massachusetts Institute of Technology....Pages 21-26
Nct Program at the University of Missouri-Columbia....Pages 27-29
Goals of the european collaboration on Boron neutron capture therapy....Pages 31-36
Critique of Mit Workshop on Neutron Beam Design, Development and Performance for Neutron Capture Therapy....Pages 37-40
Programme for BNCT with Accelerator-Produced KeV Neutrons and Related Chemical and Biological Studies....Pages 41-52
Performance of the Currently Available Epithermal Neutron Beam at the Massachusetts Institute of Technology Research Reactor (MITR-II)....Pages 53-56
A Compact Triga Reactor for Boron Neutron Capture Therapy....Pages 57-62
Design, Construction and Installation of an Epithermal Neutron Beam for BNCT at the High Flux Reactor Petten....Pages 63-66
Modelling an Epithermal Neutron Beam for a Dido Type Reactor Using Mcnp - A Monte Carlo Code....Pages 67-69
Mcnp Calculations for the Design and Characterisation of the Petten BNCT Epithermal Neutron Beam....Pages 71-73
Monte-Carlo Calculation Results for the Epithermal Neutron Beam at the Brookhaven Medical Reactor....Pages 75-78
Design Considerations for the Proposed Hifar Thermal and Epithermal Neutron Capture Therapy Facilities....Pages 79-82
Neutron Beam Parameters on LVR-15 Reactor for Neutron Capture Therapy....Pages 83-86
Study on the Best Design of Neutron Irradiation Facility for BNCT....Pages 87-90
Studsvik Thermal Neutron Facility....Pages 91-93
Effective Thermal Neutron Collimation for Neutron Capture Therapy Using Neutron Absorption and Scattering Reactions....Pages 95-99
Reevaluation of Thermal Neutron Field of the KUR Heavy Water Facility for Biomedical Uses (Optimization of Bismuth, Heavy Water and Graphite Layers)....Pages 101-105
Design of an Accelerator-Based Epithermal Neutron Beam for Boron Neutron Capture Therapy....Pages 107-112
An Integrated Neutronic and Thermal-Hydraulic Design Study for an Accelerator Neutron Irradiation Facility....Pages 113-117
An Epithermal Neutron Source for Bnct Using a Tandem Cascade Accelerator....Pages 119-122
Accelerator Based Neutron Sources for Neutron Capture Therapy....Pages 123-127
Neutrons for Capture Therapy Produced by 72 MeV Protons....Pages 129-132
A Monte Carlo Study of Ideal Beams for Epithermal Neutron Beam Development for Boron Neutron Capture Therapy....Pages 133-136
Analytical Dosimetry for Spontaneous Tumor Dogs Receiving Boron Neutron Capture Therapy....Pages 137-140
Some Physical Factors Influencing the Distributions of Thermal Neutrons and Gamma-Rays in a Phantom....Pages 141-143
Characterization of the Bmrr and PBF Epithermal-Neutron Beams in Phantom Using Three-Dimensional Deterministic Radiation Transport Theory....Pages 145-149
Beyond the Epithermal-Neutron Beam: The Analytical Physicist’s Role....Pages 151-154
Measurements of Lineal Energy Spectra for Neutron Capture Therapy Using a Boron Doped Let Chamber....Pages 155-157
Dose Measurements and Calculations in the Epithermal Neutron Beam at the Brookhaven Medical Research Reactor (BMRR)....Pages 159-161
Review of Techniques Developed at Harwell Laboratory for Neutron and Gamma-Ray Characterisation of Filtered Neutron Beams for Boron Neutron Capture Therapy....Pages 163-165
Relation Between Tolerance Dose of Skin and Boron-10 Concentration in Neutron Capture Therapy for Cutaneous Melanoma....Pages 167-171
Treatment Planning for Neutron Capture Therapy of Glioblastoma Multiforme Using an Epithermal Neutron Beam from the Mitr-II Research Reactor and Monte Carlo Simulation....Pages 173-177
Enhancement of Tumor Dose by the Gadolinium Neutron Capture Reaction in Cf-252 Brachytherapy....Pages 179-182
Gadolinium as a Neutron Capture Therapy Agent....Pages 183-186
Boron Neutron Capture Enhancement in Cf-252 Brachytherapy....Pages 187-189
Comparison of Dose Distributions with 10 Boron Augmented Sources of 252 Cf Obtained by Monte Carlo Simulation and by Experimental Measurement....Pages 191-194
Boron Neutron Capture Enhancement of the Tumor Dose in Fast Neutron Therapy Beams....Pages 195-198
Neutron Capture Reactions in a d(14)+Be Fast Neutron Beam....Pages 199-202
The Potential of Internal Neutron Sources in Capture Therapy....Pages 203-205
Carboranyl Precursors of Nucleic Acids--Potential DNA Probes for BNCT....Pages 207-210
Boron Containing Nucleic Acids....Pages 211-213
Preparation of New Boron Compounds with Potential for Application in 10 B NCT: Derivatives of Monocarbon Carboranes....Pages 215-217
Molecular Design and Synthesis of B-10 Carriers for Neutron Capture Therapy....Pages 219-222
Synthesis and Properties of Tetrakis-Carborane-Carboxylate Esters of 2,4-BIS-(α,β-Dihydroxyethyl) Deuteroporphyrin IX....Pages 223-226
Carborane Compounds for Neutron Capture Therapy of Malignant Melanoma....Pages 227-230
Synthesis of 10 B- and 157 Gd-Labelled DNA Ligands for Neutron Capture Therapy....Pages 231-233
Behaviour of the Biologically Active Sulfhydryl Group of Mercaptoundecahydro- closo -Dodecaborate(2-) (Mercaptoborate) Studied by ESR and Polarography....Pages 235-238
Synthesis and Biological Properties of Boronated Thioureas as Highly Selective Tumor Seekers for Melanoma....Pages 239-242
Complex Formation of Phenylboronic Acid Derivatives with Aldopentoses and Oligosaccharides....Pages 243-246
Optical Purity Determination of D,L-Boronophenylalanine by High Performance Liquid Chromatography with a Chiral Mobile Phase....Pages 247-250
Enantioselective Synthesis of L-(-)-4-Boronophenylalanine (L-BPA) by Asymmetric Catalytic Hydrogenation....Pages 251-254
Complete Separation of Racemic p-Boronophenylalanine by High Performance Liquid Chromatography with Crown Ether-Coated Reversed-Phase Packings....Pages 255-257
Liposomal Delivery of Boron for BNCT....Pages 259-264
Delivery of Boron-10 for Neutron Capture Therapy by Means of Monoclonal Antibody - Starburst Dendrimer Immunoconjugates....Pages 265-268
Antibody Targeting of Boron Compounds....Pages 269-271
Application of Boronated Anti-Cea Immunoliposome to Boron Neutron Capture Therapy....Pages 273-275
Studies Related to Antibody-Mediated Boron Delivery for BNCT....Pages 277-281
Continuous Measurement of Boron-10 Concentration in Rabbit Brain Tissue and Blood Using Prompt Gamma-Ray Spectrometry....Pages 283-287
Bioanalytical Investigations on Experimental BNCT with Cold Neutrons at the Jülich Research Reactor FRJ-2, Status Report....Pages 289-291
Boron Concentration Measurements for the Petten BNCT Project....Pages 293-296
Flow Injection for Sample Introduction into Inductively Coupled Plasma for the Determination of Boron in Biological Samples....Pages 297-300
Boron-10 Prompt Gamma Analysis Using a Diffracted Neutron Beam....Pages 301-304
Determination of Boron Concentration by Means of Direct Current Plasma - Atomic Emission Spectroscopy....Pages 305-308
Rapid Spectrophotometric Determination of Boron in Biological Tissue with Alkali Fusion Decomposition....Pages 309-312
Phantom Experiment and Calculation for in Vivo 10 B Analysis by Prompt Gamma-Ray Spectroscopy at the Musashi Reactor....Pages 313-315
Determination of Boron Concentration in Tissues by Means of Alpha Autoradiography....Pages 317-320
A New Boron MRI Method for Imaging BNCT Agents in Vivo....Pages 321-323
In Vivo Pharmacokinetic Evaluation of Boron Compounds Using Magnetic Resonance Spectroscopy and Imaging....Pages 325-329
Intracellular Boron Uptake and Distribution of BSH and BPA Determined Using Ion Microscopy....Pages 331-333
Uptake of Boronated Monoclonal Antibodies by Melanoma Cells Visualised by Track Etch Autoradiography and Electron Energy Loss Spectroscopy....Pages 335-338
Interaction between Boron Containing Compounds and Serum Albumin Observed by Nuclear Magnetic Resonance....Pages 339-343
The Necessity of Stochastic Radiobiology in BNCT or What is the RBE of the 10 B(n,α) 7 Li Reaction....Pages 345-348
Enhancement of Thermal Neutron Induced Killing Effect on Hela Cells Containing Boron-10 Nucleic Acid Derivatives....Pages 349-351
Further in Vitro Radiobiological Analysis on 10 B-BPA BNCT of Malignant Melanoma: Correlation of Determined 10 B-Content and Cell Killing Effect....Pages 353-356
 157 Gd-Neutron Capture: Potential of 157 Gd-Labelled DNA Ligands for Neutron Capture Therapy....Pages 357-360
Gadolinium-Neutron Capture Reactions: A Radiobiological Assay....Pages 361-363
 In Vitro Biological Efficacy of Boronated Low Density Lipoproteins for NCT....Pages 365-368
In Vitro Incorporation of Boronophenylalanine by Amelanotic and Melanotic Murine and Human Malignant Melanoma Cell Lines....Pages 369-371
Studies on the Uptake of Para-Boronophenylalanine in Melanoma Cells....Pages 373-376
Studies to Use Fission Neutrons in BNCT for Deeper Tumor Lesion....Pages 377-380
Intracellular Distribution of Various Boron Compounds in Rat 9L Gliosarcoma Cells....Pages 381-385
In Vitro Evaluation of 10 B-BPA for Melanoma at Moata - Joint Work between Japan and Australia BNCT Research Teams....Pages 387-390
Thermal Neutron Capture Therapy (NCT) Using 10 B-Conjugated Antimelanoma Antibodies: Quantification of 10 B on Cultured Human Melanoma Cells....Pages 391-394
Ultrastructural Changes in Tumour Cells Following Boron Neutron Capture Therapy....Pages 395-397
Dose Modification by Neutron Capture in Cell Culture Using a 1 MeV Mean Energy Fission Neutron Beam....Pages 399-401
Thermal Neutron Induced Decomposition and Inactivation of Several Biomolecules....Pages 403-405
Killing Effects of Gadolinium Neutron Capture Reaction on Brain Tumors....Pages 407-410
Spontaneous Canine Oral Melanoma: A Large Animal Model for BNCT....Pages 411-415
Dose-Response Analysis for Boron Neutron Capture Therapy of the B16 Murine Melanoma Using p-Boronophenylalanine....Pages 417-419
Increased Selective 10 B-Uptake by Malignant Melanoma Using Systemic Administration of 10 B 1 -BPA·Fructose Complex....Pages 421-424
Local Control of Murine Melanoma Xenografts in Nude Mice by Neutron Capture Therapy....Pages 425-428
A Rat Model for the Treatment of Melanoma Metastatic to the Brain by Means of Neutron Capture Therapy....Pages 429-434
Radiobiology of Boron Neutron Capture Therapy: Problems with the Concept of Relative Biological Effectiveness....Pages 435-437
In Vivo Cellular Pharmacology on the Selective Affinity of 10 B 1 -BPA for Malignant Melanoma....Pages 439-442
Comparative Pharmacokinetics and Distribution Studies of Boric Acid, L-BPA and BSH in Two Murine Tumour Models....Pages 443-445
Evaluation of Response of Hepatocytes(in Vivo) to Thermal Neutron Irradiation by Micronucleus Assay....Pages 447-450
Liposomes as Carriers of Boronated Thiouracils for NCT of Melanoma....Pages 451-454
Biodistribution, Toxicity and Efficacy of a Boronated Porphyrin for Boron Neutron Capture Therapy....Pages 455-457
Basic Studies in Bnct — Tolerance to Heavy Water....Pages 459-462
Boron Neutron Capture Therapy of Ocular Melanoma and Intracranial Glioma Using p-Boronophenylalanine....Pages 463-468
A Quantitative Study on Pharmacokinetics and Biodistribution of BSH in a Rat Glioma Model....Pages 469-473
Biodistribution and Pharmacokinetics of p -Boronophenylalanine in C57BL/6 Mice with GL261 Intracerebral Tumors, and Survival Following Neutron Capture Therapy....Pages 475-478
A Large Animal Model for Boron Neutron Capture Therapy....Pages 479-484
Radiobiology Studies at Petten: Status on Cell Culture, Mice and Dog Experiments....Pages 485-488
The Biodistribution of Boron in Normal Canine Tissues Following Borocaptate Sodium Administration and the Effect of Plasma Exchange....Pages 489-492
Distribution of a Boronated Porphyrin (BTPP) in Osteosarcoma Bearing Nude Mice....Pages 493-496
Feasibility Study of Boron Neutron Capture Therapy for Inoperable Liver Cancers....Pages 497-500
Tumour Localization of Boronated Porphyrins in an Intracerebral Model of Glioma....Pages 501-505
Acute and Late Reactions Following Boron Neutron Capture Epithermal-Neutron Therapy in Dogs with Spontaneous Brain Tumors....Pages 507-510
Tolerance Limits of the Normal Skin Treated by a Single Thermal Neutron Capture Therapy....Pages 511-514
Qualitative Dose Response of the Normal Canine Head to Epithermal Neutron Irradiation with and Without Boron Capture....Pages 515-519
Boron Neutron Capture Therapy: The Radiation Response of Rat Skin and Spinal Cord....Pages 521-523
Influence of BNCT Radiations on the Blood-Brain Barrier in Terms of Boron-10 Uptake....Pages 525-529
Blood-Brain Barrier and Its Manipulation: Implications for Neutron Capture Therapy....Pages 531-536
The Biodistribution of Boron in Canine Spontaneous Intracranial Tumors Following Borocaptate Sodium Infusion....Pages 537-540
Regional and Total Body Dose Following BNCT Epithermal Head Irradiation: Biologic and Dosimetric Evaluation....Pages 541-544
Biodistribution of Boron Sulfhydryl (BSH) in Humans: A Quality Control of Analytical Methods * ....Pages 545-547
Pharmacokinetics of Boron Sulfhydryl (BSH) in Patients with Intracranial Tumours * ....Pages 549-550
Biodistribution of Boron Sulfhydryl (BSH) in Patients with Intracranial Tumors * ....Pages 551-556
The Distribution of BSH in Patients with Malignant Glioma....Pages 557-560
Clinical Results of Boron Neutron Capture Therapy....Pages 561-568
Clinical Experience of Bnct for Brain Tumours at Jaeri....Pages 569-576
Advances in the Control of Human Cutaneous Primary and Metastatic Melanoma by Thermal Neutron Capture Therapy....Pages 577-583
A Proposal for Clinical Pilot Studies for Boron Neutron Capture Therapy....Pages 585-588
Proposed Clinical Approach to Bnct....Pages 589-591
Clinical Experience of Bnct for Brain and Skin Tumours at Kyoto University Reactor....Pages 593-596
The State of the Art for Radiotherapy for Brain Tumors: Nonconventional Fractionation, Heavy Ions, and Fast-Neutron Therapy....Pages 597-603
Incidence and Survival of Cancers for Which Available Treatments Appear Ineffective....Pages 605-608
Limitations in the Conventional Treatment of Cerebral Metastases from Melanoma....Pages 609-612
Photodynamic Therapy of Brain Tumours....Pages 613-617
CF-252 Neutron Brachytherapy, Neutron Capture Therapy and Teletherapy for Melanoma and Malignant Gliomas....Pages 619-624
Problems of Dose Fractionation in BNCT....Pages 625-645
Back Matter....Pages 647-668