Principles of Molecular Oncology

Front Matter....Pages i-xxi
Front Matter....Pages 1-1
Selecting the Right Targets for Cancer Therapy....Pages 3-49
Clinical Importance of Prognostic Factors....Pages 51-72
Genetic Markers in Sporadic Tumors....Pages 73-150
Genetic Markers in Breast Tumors with Hereditary Predisposition....Pages 151-179
Cellular and Tissue Markers in Solid Tumors....Pages 181-213
Molecular and Pathological Characterization of Human Tumors....Pages 215-232
Circulating Tumor Markers....Pages 233-246
Proteomics-Based Approaches....Pages 247-264
Front Matter....Pages 265-265
Growth Factor Signaling Pathways in Cancer....Pages 267-315
Estrogen Action and Breast Cancer....Pages 317-358
Cyclin-Dependent Kinases and Their Regulators as Potential Targets for Anticancer Therapeutics....Pages 359-410
Angiogenesis Switch Pathways....Pages 411-441
Invasion and Metastasis....Pages 443-461
Molecular Pathways of Drug Resistance....Pages 463-489
Genomic Instability, DNA Repair Pathways, and Cancer....Pages 491-504
Front Matter....Pages 505-505
Immunotherapy for Human Cancer....Pages 507-528
Treatment with Monoclonal Antibodies....Pages 529-568
Emerging Molecular Therapies....Pages 569-606
Treatment of Carcinogenesis....Pages 607-673
Suicide Gene Therapy....Pages 675-694
Back Matter....Pages 695-709