Predictive Biomarkers in Oncology: Applications in Precision Medicine

Front Matter ....Pages i-xxi
Front Matter ....Pages 1-1
 Introduction to Predictive Biomarkers: Definitions and Characteristics  (Clive R. Taylor)....Pages 3-18
 Introduction to Clinical Trials, Clinical Trial Designs, and Statistical Terminology Used for Predictive Biomarker Research and Validation  (Karla V. Ballman)....Pages 19-36
 Overview of Methods Used in Predictive Biomarker Studies in a Molecular Anatomic Pathology Laboratory  (Perry Maxwell, Manuel Salto-Tellez)....Pages 37-44
 Significance of Immunohistochemistry and In Situ Hybridization Techniques for Predictive Biomarker Studies  (Hans-Ulrich Schildhaus)....Pages 45-62
 Overview of PCR-Based Technologies and Multiplexed Gene Analysis for Biomarker Studies  (Yesim Gökmen-Polar)....Pages 63-73
 Introduction to Microarray Technology  (Nallasivam Palanisamy)....Pages 75-85
 Digital and Computational Pathology for Biomarker Discovery  (Peter Hamilton, Paul O’Reilly, Peter Bankhead, Esther Abels, Manuel Salto-Tellez)....Pages 87-105
 Detection of Predictive Biomarkers Using Liquid Biopsies  (Andrew A. Davis, Massimo Cristofanilli)....Pages 107-117
 Measurement of Predictive Cancer Biomarkers by Flow Cytometry  (Prashant Ramesh Tembhare, Sumeet Gujral, H. Krishnamurthy)....Pages 119-129
 Personalized Cancer Treatment and Patient Stratification Using Massive Parallel Sequencing (MPS) and Other OMICs Data  (Mark Abramovitz, Casey Williams, Pradip K. De, Nandini Dey, Scooter Willis, Brandon Young et al.)....Pages 131-147
 Bioinformatic Methods and Resources for Biomarker Discovery, Validation, Development, and Integration  (Júlia Perera-Bel, Andreas Leha, Tim Beißbarth)....Pages 149-164
Front Matter ....Pages 165-165
 Overview of Cell Signaling Pathways in Cancer  (Amanda J. Harvey)....Pages 167-182
 Steroid Hormone and Nuclear Receptor Signaling Pathways  (Sunil Badve)....Pages 183-197
 Protein Kinase C Signaling in Carcinogenesis  (Thao N. D. Pham, Debra A. Tonetti)....Pages 199-206
 Roles of Rho/ROCK in Cancer Signaling  (Yesim Gökmen-Polar)....Pages 207-212
 Mitogen-Activated Protein Kinase (MAPK) Signaling  (Andrei Zlobin, Jeffrey C. Bloodworth, Clodia Osipo)....Pages 213-221
 Notch Signaling Pathway in Carcinogenesis  (Andrei Zlobin, Jeffrey C. Bloodworth, Andrew T. Baker, Clodia Osipo)....Pages 223-230
 Signaling of the ErbB Receptor Family in Carcinogenesis and the Development of Targeted Therapies  (Zheng Cai, Payal Grover, Zhiqiang Zhu, Mark I. Greene, Hongtao Zhang)....Pages 231-242
 Angiogenic Signaling Pathways and Anti-angiogenic Therapies in Human Cancer  (Aejaz Nasir)....Pages 243-262
 Role of PI3K/AKT/mTOR in Cancer Signaling  (Nicci Owusu-Brackett, Maryam Shariati, Funda Meric-Bernstam)....Pages 263-270
 Met Signaling in Carcinogenesis  (Dinuka M. De Silva, Arpita Roy, Takashi Kato, Donald P. Bottaro)....Pages 271-282
 Role of Insulin-Like Growth Factor Receptors in Cancer Signaling  (Douglas Yee)....Pages 283-288
 Role of Wnt/β-Catenin Pathway in Cancer Signaling  (Casey D. Stefanski, Jenifer R. Prosperi)....Pages 289-295
 Hedgehog Signaling in Carcinogenesis  (Victor T. G. Lin, Tshering D. Lama-Sherpa, Lalita A. Shevde)....Pages 297-304
 TGF-β and the SMAD Signaling Pathway in Carcinogenesis  (Wendy Greenwood, Alejandra Bruna)....Pages 305-310
 Role of JAK-STAT Pathway in Cancer Signaling  (Na Luo, Justin M. Balko)....Pages 311-319
 NF-κB Signaling Pathways in Carcinogenesis  (Harikrishna Nakshatri)....Pages 321-325
 Immune Signaling in Carcinogenesis  (Mahesh Yadav, Marcin Kowanetz, Hartmut Koeppen)....Pages 327-334
 Predictive Biomarkers and Targeted Therapies in Immuno-oncology  (Hartmut Koeppen, Mark L. McCleland, Marcin Kowanetz)....Pages 335-344
 Role of Protein Tyrosine Phosphatases in Cancer Signaling  (Elie Kostantin, Yevgen Zolotarov, Michel L. Tremblay)....Pages 345-351
Front Matter ....Pages 353-353
 Predictive and Prognostic Biomarkers in Myeloid Neoplasms  (Raju K. Pillai)....Pages 355-362
 Predictive Biomarkers and Targeted Therapies for Lymphoid Malignancies  (Raju K. Pillai, Bharat N. Nathwani, Lixin Yang)....Pages 363-374
 Targeted Therapies for Pediatric Central Nervous System Tumors  (Nicholas Shawn Whipple, Amar Gajjar)....Pages 375-382
 Predictive Biomarkers and Targeted Therapies in Adult Brain Cancers  (Jose M. Bonnin)....Pages 383-391
 Predictive Biomarkers and Targeted Therapies in Breast Cancer  (Sunil Badve)....Pages 393-402
 Predictive Biomarkers in Lung Cancer  (Reinhard Buettner)....Pages 403-409
 Predictive Biomarkers and Targeted Therapies in Genitourinary Cancers  (Li Yan Khor, Puay Hoon Tan)....Pages 411-422
 Predictive Biomarkers and Targeted Therapies in Colorectal Cancer  (Susan D. Richman, Bharat Jasani)....Pages 423-430
 Predictive Markers and Targeted Therapies in Gastroesophageal Cancer (GEC)  (Josef Rüschoff)....Pages 431-435
 Predictive Biomarkers and Targeted Therapies in Hepatic, Pancreatic, and Biliary Cancers  (Steven Alexander Mann, Romil Saxena)....Pages 437-444
 Predictive Biomarkers and Targeted Therapies in Gynecological Cancers  (Louise De Brot, Fernando Augusto Soares)....Pages 445-456
 Predictive Biomarkers and Targeted Therapies in Head and Neck Cancer  (Felipe D’Almeida Costa, Fernando Augusto Soares)....Pages 457-462
 Predictive Biomarkers and Targeted Therapies in the Skin  (Aaron Phelan, Simon J. P. Warren)....Pages 463-474
 Predictive Biomarkers and Targeted Therapies in Sarcomas  (Hans-Ulrich Schildhaus, Sebastian Bauer)....Pages 475-492
 Predictive Markers and Targeted Therapies in Thyroid Cancer and Selected Endocrine Tumors  (Juan C. Hernandez-Prera, Bruce M. Wenig)....Pages 493-500
 The Response Evaluation Criteria in Solid Tumors (RECIST)  (Kate Lathrop, Virginia Kaklamani)....Pages 501-511
Front Matter ....Pages 513-513
 IVDs and FDA Marketing Authorizations: A General Overview of FDA Approval Process of an IVD Companion Diagnostic Device in Oncology  (Shyam Kalavar, Reena Philip)....Pages 515-523
 Quality Control of Immunohistochemical and In Situ Hybridization Predictive Biomarkers for Patient Treatment: Experience from International Guidelines and International Quality Control Schemes  (Petra Heinmöller, Gudrun Bänfer, Marius Grzelinski, Katya Victoria Alexander, Kathrina A. Alexander, Bharat Jasani)....Pages 525-537
 Use of Companion Diagnostics (CDx) and Predictive Biomarkers for Cancer Targeted Therapy: Clinical Applications in Precision Medicine  (Rosanne Welcher)....Pages 539-551
 Policy Issues in the Clinical Development and Use of Predictive Biomarkers for Molecular Targeted Therapies  (V. M. Pratt)....Pages 553-558
 Role of Central Laboratories in Research, Validation, and Application of Predictive Biomarkers  (Oliver Stoss, Thomas Henkel)....Pages 559-567
Front Matter ....Pages 569-569
 Prominent Precision Medicine Clinical Trials in Oncology Around the World  (George Louis Kumar)....Pages 571-592
 Precision Medicine Clinical Trials: Successes and Disappointments, Challenges and Opportunities – Lessons Learnt  (Mark Abramovitz, Casey Williams, Pradip K. De, Nandini Dey, Scooter Willis, Brandon Young et al.)....Pages 593-603
 FDA-Approved Targeted Therapies in Oncology  (George Louis Kumar)....Pages 605-622
Back Matter ....Pages 623-642