Preclinical Hyperthermia

Front Matter....Pages I-XI
Hyperthermic Toxicity and the Modulation of Heat Damage to Cell Protein Synthesis in HeLa Cells....Pages 1-8
Membranes as Targets for Hyperthermic Cell Killing....Pages 9-21
Sulfhydryl Compounds as Thermosensitizers....Pages 22-27
Therapeutic Benefit from Combined Heat and Radiation....Pages 28-34
Correlation Between Polymerase ß Activity and Thermal Radiosensitization in Chinese Hamster Ovary Cells....Pages 35-41
The Problem of Defining Thermal Dose....Pages 42-49
Effect of Hyperthermia on Human Natural Killer Cells....Pages 50-56
Effect of Hyperthermia at 40.5° C and Cytostatic Drugs on Human Bone Marrow Progenitor Cells....Pages 57-63
Combined Heat and X-Ray Toxicities in Intestine and Skin....Pages 64-70
Toxic Effects of Irradiation or Doxorubicin in Combination with Moderate Whole-Body Hyperthermia on Bone Marrow in Rats....Pages 71-82
Cardiotoxicity of Moderate Whole-Body Hyperthermia, Doxorubicin, and Combined Treatment in Rats....Pages 83-88
Effects of Hyperthermic Treatments on Malignant Cells and Animal Tumors: Introductory Remarks....Pages 89-95
Hyperthermia and Microcirculatory Effects of Heat in Animal Tumors....Pages 96-108
Importance of the Glutathione Level and the Activity of the Pentose Phosphate Pathway in Cellular Heat Sensitivity....Pages 109-125
Potentiation of Hyperthermia by Lanthanum....Pages 126-135
Interactions of Hyperthermia with Hypoxic Cell Sensitisers....Pages 136-148
Thermal Enhancement of the Cell Killing Effect of X-Irradiation in Mammalian Cells in Vitro and in a Transplantable Mouse Tumor: Influence of pH, Thermotolerance, Hypoxia, or Misonidazole....Pages 149-160
Thermal Enhancement of Drug Cytotoxicity in Vivo and in Vitro....Pages 161-169
Preclinical Hyperthermia in Human Tumors: Introductory Remarks....Pages 170-172
Microcirculatory and pH Alterations in Isotransplanted Rat and Xenotransplanted Human Tumors Associated with Hyperthermia....Pages 173-182
Effects of Heat Treatment in Vitro and in Vivo on Human Melanoma Xenografts....Pages 183-197
Intrinsic Thermosensitivity of Various Human Tumors....Pages 198-202
Importance of Thermotolerance for Radiothermotherapy as Assessed Using Two Human Melanoma Cell Lines....Pages 203-213
In Vitro Thermochemotherapy in Ovarian Cancer....Pages 214-223
Effect of Hyperthermia at 40.5° C and Chemotherapy on Various Human Tumors in Vitro....Pages 224-238
Predictive Assays for Tumor Response to Single and Multiple Fractions of Hyperthermia....Pages 239-249
Predicting the Sensitivity of Human Cancers to Combined Chemotherapy and Hyperthermia....Pages 250-257
Back Matter....Pages 258-263