Pre-Clinical and Clinical Methods in Brain Trauma Research

Front Matter ....Pages i-xiv
 Traumatic Brain Injury  (Amit K. Srivastava, Charles S. Cox Jr.)....Pages 1-14
 Three-Dimensional In Vitro Brain Tissue Models  (Min D. Tang-Schomer)....Pages 15-36
 Modeling Traumatic Brain Injury In Vitro  (Daniel E. Bonder, Carolyn E. Keating, Namas Chandra, D. Kacy Cullen, Bryan J. Pfister)....Pages 37-69
 Drosophila Model to Study Chronic Traumatic Encephalopathy  (Rojahne Azwoir, Liam Chen)....Pages 71-80
 Controlled Cortical Impact for Modeling Traumatic Brain Injury in Animals  (Nicole Osier, C. Edward Dixon)....Pages 81-95
 Fluid Percussion Model of Traumatic Brain Injury  (Rachel K. Rowe, Daniel Griffiths, Jonathan Lifshitz)....Pages 97-110
 Development of a Rodent Model of Closed Head Injury: The Maryland Model  (Erik Hayman, Kaspar Kaledjian, Vladimir Gerzanich, J. Marc Simard)....Pages 111-121
 Rodent Model of Primary Blast-Induced Traumatic Brain Injury: Guidelines to Blast Methodology  (Venkatasivasai Sujith Sajja, Peethambaram Arun, Stephen A. Van Albert, Joseph B. Long)....Pages 123-138
 Cognitive and Motor Function Assessments in Rodent Models of Traumatic Brain Injury  (Danielle Scott, Kathryn E. Saatman)....Pages 139-154
 Pre-Procedural Considerations and Post-Procedural Care for Animal Models with Experimental Traumatic Brain Injury  (Mary A. Robinson, Samer M. Jaber, Stacey L. Piotrowski, Thomas H. Gomez)....Pages 155-172
 Laser Capture Microdissection of Single Cells, Cell Populations, and Brain Regions Affected by Traumatic Brain Injury  (Harris A. Weisz, Deborah R. Boone, Stacy L. Sell, Helen L. Hellmich)....Pages 173-190
 Rat Microglia Isolation and Characterization Using Multiparametric Panel for Flow Cytometric Analysis  (Naama E. Toledano Furman, Karthik S. Prabhakara, Supinder Bedi, Charles S. Cox Jr., Scott D. Olson)....Pages 191-199
 The Principles of Experimental Design and the Determination of Sample Size When Using Animal Models of Traumatic Brain Injury  (Michael F. W. Festing)....Pages 201-225
 Advanced Informatics Methods in Acute Brain Injury Research  (Jude P. J. Savarraj, Mary F. McGuire, Ryan Kitagawa, Huimahn Alex Choi)....Pages 227-242
 Rapid Detection and Monitoring of Brain Injury Using Sensory-Evoked Responses  (Jonathan A. N. Fisher, Cristin G. Welle)....Pages 243-256
 Advanced Neuroimaging Methods in Traumatic Brain Injury  (Jenifer Juranek)....Pages 257-270
 Dynamic Contrast-Enhanced MRI for the Analysis of Blood-Brain Barrier Leakage in Traumatic Brain Injury  (Qiang Shen, Timothy Q. Duong)....Pages 271-282
 Assessments for Quantifying Neuromotor Functioning After Repetitive Blast Exposure  (Christopher K. Rhea, Nikita A. Kuznetsov, W. Geoffrey Wright, F. Jay Haran, Scott E. Ross, Josh L. Duckworth)....Pages 283-305
 Translingual Neurostimulation (TLNS): Perspective on a Novel Approach to Neurorehabilitation after Brain Injury  (Yuri Danilov, Dafna Paltin)....Pages 307-327
 The Rapid Templating Process for Large Cranial Defects  (Jeremy Kwarcinski, Philip Boughton, Andrew Ruys, James van Gelder)....Pages 329-348
 Computer-Assisted Approaches to Identify Functional Gene Networks Involved in Traumatic Brain Injury  (Anthony San Lucas, John Redell, Pramod Dash, Yin Liu)....Pages 349-360
 Clinical Trials for Traumatic Brain Injury: Designs and Challenges  (Juan Lu, Mirinda Gormley)....Pages 361-378
Back Matter ....Pages 379-381