Porphyrin Photosensitization

Front Matter....Pages i-ix
Introduction....Pages 1-2
Photoradiation Therapy — Clinical and Drug Advances....Pages 3-13
Intra-Abdominal Applications of Hematoporphyrin Photoradiation Therapy....Pages 15-21
Effectiveness of HPD and Radiation Therapy in Lung Cancer....Pages 23-39
Hematoporphyrin Derivative in the Diagnosis and Treatment of Lung Cancer....Pages 41-46
Laser Photoradiation Therapy of Recurrent Human Breast Cancer and Cancer of the Head and Neck....Pages 47-52
HPD Photoradiation Therapy for Cancer at Kingston and Hamilton....Pages 53-62
Light Dosimetry in Tissue: Application to Photoradiation Therapy....Pages 63-76
Thermal Distribution During Photoradiation Therapy....Pages 77-90
Photobiologic Considerations in Photoradiation Therapy....Pages 91-108
Preclinical Evaluation of Hematoporphyrin Derivative for the Treatment of Intraocular Tumors: A Preliminary Report....Pages 109-114
Porphyrin Localizing Phenomena....Pages 115-127
Aspects of the Cellular Uptake and Retention of Hematoporphyrin Derivative and Their Correlation with the Biological Response to PRT in Vitro....Pages 129-138
Cellular Uptake, Excretion and Localization of Hematoporphyrin Derivative (HPD)....Pages 139-150
Studies of HPD: Chemical Composition and in Vitro Photosensitization....Pages 151-164
Hematoporphyrin Derivative: Chemical Composition, Photochemical and Photosensitizing Properties....Pages 165-179
A Preliminary Comparison of the Photosensitizing Properties of Porphyrins in Aqueous Solution and Liposomal Systems....Pages 181-192
Factors Governing the Mechanism and Efficiency of Porphyrin-Sensitized Photooxidations in Homogeneous Solutions and Organized Media....Pages 193-212
Photodynamic Action of Protoporphyrin on Resealed Erythrocyte Membranes: Mechanisms of Release of Trapped Markers....Pages 213-225
Photodynamic Membrane Damage....Pages 227-240
HPD — A Study of Its Components and Their Properties....Pages 241-250
The Analysis of Hematoporphyrin Derivative....Pages 251-263
Potential use of Radiolabelled Porphyrins for Tumor Scanning....Pages 265-278
Excited State Interactions of Protoporphyrin IX and Related Porphyrins with Molecular Oxygen in Solutions and in Organized Assemblies....Pages 279-292
Back Matter....Pages 293-294