Polymeric Drugs and Drug Delivery Systems

Polymeric Drugs and Drug Delivery Systems......Page 1
Table of Contents......Page 3
Preface......Page 10
INTRODUCTION......Page 12
Table of Contents......Page 0
SYNTHESIS OF SEMITELECHELIC HPMA POLYMERS......Page 13
CHARACTERIZATION OF SEMITELECHELIC HPMA POLYMERS......Page 17
MODIFICATION OF PROTEINS WITH SEMITELECHELIC HPMA POLYMERS......Page 19
MODIFICATION OF BIOMEDICAL SURFACES WITH SEMITELECHELIC HPMA POLYMERS......Page 22
CONCLUSIONS......Page 23
REFERENCES......Page 24
INTRODUCTION......Page 26
SYNTHESIS OF A-B BLOCK COPOLYMERS OF PIPAAm WITH VARIOUS HYDROPHOBIC SEGMENTS......Page 31
Core-Shell Micellar Structure Formation......Page 33
Reversible Structural Change Responding to Temperature Change......Page 37
ADRIAMYCIN (ADR)INCORPORATION INTO PIPAAm-PBMA MICELLES......Page 41
THERMORESPONSIVE ADR RELEASE FORM POLYMERIC MICELLES......Page 42
CYTOTOXICITY OF POLYMERIC MICELLES MODULATED BY TEMPERATURE CHANGES......Page 43
REFERENCES......Page 47
INTRODUCTION......Page 50
Synthesis......Page 51
FT-IR Measurement......Page 52
Permeation Experiments......Page 53
PH/TEMPERATURE-INDUCED PHASE TRANSITION......Page 54
THERMOSENSITIVE PERMEATION......Page 60
GLUCOSE-SENSITIVE INSULIN RELEASE......Page 61
CONCLUSIONS......Page 64
REFERENCES......Page 65
INTRODUCTION......Page 67
EXPERIMENTAL......Page 68
RESULTS AND DISCUSSION......Page 70
By Slow Solvent Evaporation......Page 71
By Co-precipitation......Page 72
MICROPARTICLE PURIFICATION AND CHARACTERIZATION......Page 73
REFERENCES......Page 76
INTRODUCTION......Page 78
EXPERIMENTAL......Page 79
DRUG RELEASE KINETICS......Page 80
RESULTS AND DISCUSSION......Page 81
CONCLUSIONS......Page 92
REFERENCES......Page 93
IMAGING PRINCIPLES AND MODALITIES......Page 95
DIAGNOSTIC LIPOSOMES AND MICELLES WITH PAPS......Page 97
EXPERIMENTAL VISUALIZATION WITH PAP-CONTAINING MICROPARTICULAR CONTRAST AGENTS......Page 103
REFERENCES......Page 107
INTRODUCTION......Page 109
CONTROLLED RELEASE FROM PLGA MICROSPHERES......Page 110
CONJUGATION OF PLGA TO DRUGS......Page 111
CONJUGATION OF PLGA TO LYSOZYME......Page 112
CONJUGATION OF PLGA TO AN AMINO ACID DERIVATIVE......Page 114
CONJUGATION OF PLGA TO DOXORUBICIN......Page 117
REFERENCES......Page 121
INTRODUCTION......Page 123
SYNTHESIS AND CHARACTERIZATION OF POLY (LYS-25)......Page 125
PREPARATION AND CHARACTERIZATION OF CROSSLINKED POLY (LYS-25)......Page 129
CONCLUSIONS......Page 133
REFERENCES......Page 136
INTRODUCTION......Page 138
GENETICALLY ENGINEERED BIOMATERIALS......Page 139
COILED COILS......Page 140
RATIONALE......Page 141
BIOSYNTHESIS OF COILED-COIL PROTEIN DOMAINS......Page 144
DYNAMIC SWELLING OF THE HYBRID HYDROGELS......Page 145
STIMULI-SENSITIVITY OF THE HYBRID HYDROGELS......Page 146
CONCLUSIONS AND FUTURE PERSPECTIVES......Page 147
REFERENCES......Page 149
INTRODUCTION......Page 151
SLOW SWELLING OF HYDROGELS......Page 152
HYDROGELS,MICROPOROUS HYDROGELS, AND MACROPOROUS HYDROGELS......Page 153
SUPERPOROUS HYDROGELS (SPHs)......Page 155
PORO(SI)GEN TECHNIQUE......Page 156
GAS-BLOWING (OR FOAMING)TECHNIQUE......Page 157
FAST SWELLING OF SPHs AND SPH COMPOSITES......Page 158
DIET CONTROL......Page 159
FUTURE OF SPHs AND SPH COMPOSITES......Page 160
REFERENCES......Page 161
INTRODUCTION......Page 162
SWELLING STUDIES......Page 163
THERMAL ANALYSIS......Page 164
RESULTS OF SWELLING STUDIES......Page 165
RESULTS OF THERMAL ANALYSIS......Page 168
RESULTS OF DIFFUSION STUDIES......Page 169
REFERENCES......Page 172
INTRODUCTION......Page 174
GRAVIMETRIC MEASUREMENTS......Page 175
DENSITY MEASUREMENTS......Page 176
SORPTION ISOTHERMS......Page 177
MECHANICAL PROPERTIES......Page 179
ANALYSIS OF THE SORPTION ISOTHERMS......Page 180
DISCUSSION......Page 183
CONCLUSIONS......Page 184
REFERENCES......Page 185
INTRODUCTION......Page 186
MATERIALS......Page 188
METHODS......Page 189
RESULTS......Page 190
CONCLUSIONS......Page 198
REFERENCES......Page 199
INTRODUCTION......Page 201
ISOLATION OF CYTOKINE-INDUCING GLYCOLIPIDS......Page 202
BIOLOGICAL ASSAYS......Page 203
FRACTIONATION OF LTA FRACTION......Page 204
STRUCTURE OF QM-I [9 ]......Page 206
FUNDAMENTAL STRUCTURE OF GL4......Page 207
CYTOKINE-INDUCING OTHER GLYCOLIPIDS OBTAINED BY THE MODIFIED SEPARATION METHOD......Page 209
PRESENCE OF COMMON LIPOPHILIC BUILDING BLOCKS......Page 211
REFERENCES......Page 213
INTRODUCTION......Page 215
RATIONALE FOR DESIGN......Page 217
CHEMISTRY OF VEHICLES......Page 220
DCE VEHICLE CHARACTERIZATION......Page 222
ANTI-VIRAL DESIGN PARAMETERS......Page 224
CONTRACEPTIVE DESIGN PARAMETERS......Page 226
VEHICLE BIOADHESION......Page 228
FUTURE CONSIDERATIONS......Page 229
REFERENCES......Page 231
INTRODUCTION......Page 235
EXPERIMENTAL......Page 237
RESULTS AND DISCUSSION......Page 239
REFERENCES......Page 242
INTRODUCTION......Page 243
MATERIALS......Page 244
DCM-Dex......Page 245
PREPARATION OF THE CONJUGATES......Page 246
ANTITUMOR ACTIVITY IN VIVO......Page 247
RESULTS AND DISCUSSION......Page 248
REFERENCES......Page 254
INTRODUCTION......Page 255
DEBENZYLATION......Page 257
SYNTHESIS OF NATURAL-AND NON-NATURAL-TYPE LINEAR AMINOPOLYSACCHARIDES......Page 258
SYNTHESIS OF HYPERBRANCHED AMINOPOLYSACCHARIDE......Page 262
CONCLUSIONS......Page 266
REFERENCES......Page 267
INTRODUCTION......Page 269
Poly(L-Lc)Microspheres by Solvent Extraction Method......Page 270
MEASUREMENTS OF DIAMETERS OF MICROSPHERES AND OF MOLECULAR WEIGHT OF POLYMERS IN MICROSPHERES......Page 271
DIAMETERS AND DIAMETER DISTRIBUTIONS OF MICROSPHERES......Page 272
DIAMETERS OF MICROSPHERES OBTAINED BY SOLVENT EXTRACTION METHOD......Page 274
DIAMETERS AND DIAMETER DISTRIBUTION OF POLY(L-Lc) MICROSPHERES OBTAINED BY RING-OPENING POLYMERIZATION......Page 277
REFERENCES......Page 281
INTRODUCTION......Page 283
EXPERIMENTAL......Page 284
ANTHRACENE......Page 285
RE-COMPLEX......Page 288
REFERENCES......Page 291
INTRODUCTION......Page 292
SYNTHETIC PROCEDURE I [5 ]......Page 295
SYNTHETIC PROCEDURE II [6,7 ]......Page 296
POLYMERIZATION OF 2-HYDROXYETHYL METHACRYLATE (HEMA)AND METHYL METHACRYLATE (MMA)......Page 297
RESULTS AND DISCUSSION......Page 298
REFERENCES......Page 303
INTRODUCTION......Page 304
METHACRYLATE RESIN FORMULATIONS......Page 305
PREPARATION AND CHARACTERIZATION OF THE FILLERS......Page 306
PREPARATION AND CHARACTERIZATION OF COMPOSITE DISK SPECIMENS......Page 307
MECHANICAL TESTING OF THE COMPOSITES......Page 308
RESULTS AND DISCUSSION......Page 309
REFERENCES......Page 313