Platinum Coordination Complexes in Cancer Chemotherapy: Proceedings of the Fourth International Symposium on Platinum Coordination Complexes in Cancer Chemotherapy convened in Burlington, Vermont by the Vermont Regional Cancer Center and the Norris Cotton Cancer Center, June 22–24, 1983

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Nomenclature for Platinum Antitumor Compounds....Pages 3-8
Front Matter....Pages 9-9
Overview....Pages 11-13
Chemical and Biological Studies of cis — Diamminedichloroplatinum (II) Binding to DNA....Pages 14-26
Is DNA the Real Target of Antitumor Platinum Compounds?....Pages 27-38
Specific Binding of cis -Platinum Compounds to DNA and DNA Fragments....Pages 39-63
Front Matter....Pages 65-65
Overview....Pages 67-70
Plasma Pharmacokinetics, Urinary Excretion, and Tissue Distribution of Platinum Following IV Administration of Cyclobutanedicarboxylatoplatinum-II and cis -Platinum to Rabbits....Pages 71-81
Clinical Pharmacokinetics of Diammine [1,1-Cydobutanedicarboxylato (2-)]-0,0′-Platinum (CBDCA)....Pages 82-89
Biliary Excretion, Renal Handling and Red Cell Uptake of Cisplatin and CBDCA in Animals....Pages 90-102
Biodistribution and Pharmacokinetics of 195mPt-Labeled cis -Dichloro- trans -Dihydroxo- bis (Isopropylamine) Platinum (IV), CHIP, In the Normal Female Fischer 344 Rat....Pages 103-113
Clinical Pharmacokinetics of cis -Dichloro- trans -Dihydroxy- bis (Isopropylamine)Platinum(IV)....Pages 114-125
Disposition of Cisplatin vs Total Platinum in Animals and Man....Pages 126-147
Front Matter....Pages 149-149
Overview....Pages 151-153
Diethyldithiocarbamate and cis -Platinum Toxicity....Pages 154-164
Selected Aspects of Cisplatin Nephrotoxicity in the Rat and Man....Pages 165-186
Evaluation of Platinum Complexes for Emetic Potential....Pages 187-209
Front Matter....Pages 211-211
Overview....Pages 213-215
Synthesis and Testing of Platinum Analogues — An Overview....Pages 216-227
Experimental Antitumor Activity of Platinum Coordination Complexes....Pages 228-239
JM8 Development and Clinical Projects....Pages 240-263
Front Matter....Pages 265-265
Structure Activity Relationship of Antitumor Palladium Complexes....Pages 267-278
The Metallocene Dihalides — A Class of Organometallic Early Transition Metal Complexes as Antitumor Agents....Pages 279-289
The Design of Metal Complexes as Anticancer Drugs....Pages 290-304
Front Matter....Pages 305-305
Overview....Pages 307-309
Phase I and Early Phase II Trials of 4′Carboxyphthalato (1,2 Diaminocyclohexane) Platinum (II)....Pages 310-320
High Dose Cisplatin in Hypertonic Saline: Renal Effects and Pharmacokinetics of a 40 MG/M 2 QD × 5 Schedule....Pages 321-329
Clinical Experience with 1, 1-Diaminomethylcyclohexane (Sulphato) Platinum (II) (TNO-6)....Pages 330-356
Front Matter....Pages 357-357
Cisplatin — Past, Present and Future....Pages 359-376
Back Matter....Pages 377-384