Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy: Proceedings of the Fifth International Symposium on Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy Abano, Padua, ITALY - June 29–July 2, 1987

Front Matter....Pages I-XLVI
Front Matter....Pages 1-1
Kinetics of Formation of Genotoxic Platinum-DNA Lesions in Vivo ....Pages 3-15
The Role of Platinum-DNA Interactions in the Cellular Toxicity and Anti-Tumour Effects of Platinum Co-Ordination Compounds....Pages 16-31
 In Vivo Cis -Diamminedichloroplatinum(II)-DNA Adduct Formation and Removal as Measured with Immunochemical Techniques....Pages 32-46
Oligonucleotide Modelling of Cis -Platinum Binding to DNA....Pages 47-61
Macromolecular Antitumor Drugs: Pharmacology and Biology....Pages 62-66
Unusual Hairpin-Like Conformations of Oligonucleotides Induced by Platinum Anti-Cancer Drugs....Pages 67-73
Cisplatin-Radiation Interactions in Tumours and Normal Tissues....Pages 74-80
Linkage Isomers of Platinum Complexes of ANT (2-amino-5-nitrothiazole) Differ in their DNA-Binding and Radiosensitization....Pages 81-82
Competition between DNA and Orthophosphate for Coordination with Platinum(II) Complexes....Pages 83-88
Effect of Cis -Diamminedichloroplatinum(II) on the Nucleotide Pool of Treated P388 Leukemia Cells....Pages 89-98
Platinum Cytostatics Design Method Based on Topological Indices....Pages 99-101
Kinetics of Changes in the Secondary Structure of DNA Induced by the Binding of Platinum Cytostatics....Pages 102-109
The Influence of the 3’-Base on the Kinetics of the Binding of [PtCl(dien)]Cl to the Dinucleotides d(GpH) (H = A,C,T)....Pages 110-114
 In Vitro Repair of Cisplatin-Dna Adducts by a Defined Enzyme System....Pages 115-126
Importance of DNA Sequence in the Reaction of d(ApG) and d(GpA) with Cis -Diamminedichloroplatinum (II)....Pages 127-131
Changes in UV-Absorbance are Due to Slow and Fast Conformational Rearrangements during DNA-Platination....Pages 132-138
Visualization of Cisplatin-DNA and Carboplatin-DNA Adducts in Tissues and Cultured Cells....Pages 139-143
Qualitative Investigation, Both in Vivo and in Vitro , of the Metabolites Formed by Cisplatin and Paraplatin Involving High Performance Liquid Chromatography Analysis....Pages 144-159
Front Matter....Pages 161-161
Cisplatin Efficacy and Toxicity: Are they Separable?....Pages 163-177
Mechanisms of Resistance to Platinum Drugs....Pages 178-196
Front Matter....Pages 161-161
High Dose Cisplatin and Drug Resistance: Clinical and Laboratory Correlations....Pages 197-206
Covalent Binding of Platinum to Kidney Subcellular Fractions from Guinea Pig Strains Sensitive or Resistant to Cisplatin Toxicity....Pages 207-215
Inhibition of Platinum Drug Toxicity by Diethyldithiocarbamate....Pages 216-227
Biochemical Modulation of Cisplatin....Pages 228-234
Effects of Cisplatin and Carboplatin on Neurohypophysis, Parathyroid and their Role in Nephrotoxicity....Pages 235-247
Cisplatin Uptake Mediated Cisplatin-Resistance in Human Ovarian Carcinoma Cells....Pages 248-254
Integrated Polymerase and Exonuclease Activities of Escherichia Coli DNA Polymerase I on Platinated DNA....Pages 255-266
Administration Route of Cis -Platinum Plays an Important Role in the in Vivo Pharmacokinetics....Pages 267-273
Cytotoxicity of the Diethyldithiocarbamate Anion, of its S-Methylester and of Respective Platinum (II) Complexes....Pages 274-281
Enzymuria in Cisplatin-Induced Kidney Damage as an Index of its Reversal by Combined Treatment with Diethyldithiocarbamate....Pages 282-289
Biotransformations of Platinum Compounds with the 1,2-Diaminocyclohexane Carrier Ligand in Cultured L1210 Leukemia Cells....Pages 290-300
Protective Effect of Procaine Against Cisplatin Induced Nephrotoxicity in Mice....Pages 301-306
Antitumor Activity and Toxicity of Selected Platinum Complexes....Pages 307-309
The Interaction and Degradation of Xanthine Bases with Platinum Metals....Pages 310-312
Interference of Thio-Compounds with Cis -Diamminodichloroplatinum (DDP) on Tumor Cells in Vitro ....Pages 313-314
A New Class of Hypoxic Cytotoxins [PtCl 2 (NH 3 ) (nitroimidazole)]....Pages 315-323
Cisplatin Interactions with Reduced Glutathione: An in Vitro Study....Pages 324-325
Determination of Platinum and Biologically Essential Trace Elements by Neutron Activation Analysis in Pharmacokinetic Studies on Cisplatin Derivatives with Estrophilic Ligands....Pages 326-333
Synthesis and Therapeutic Effect of New Cis -Platinum Complexes on Experimental Tumors....Pages 334-342
Front Matter....Pages 343-347
The Development of More Effective Platinum Therapy....Pages 349-349
Platinum Radiosensitizers....Pages 351-354
Platinum Coordination Derivatives by the Intraperitoneal Route: Pharmacokinetics and Clinical Results....Pages 355-366
Chemotherapy of Head and Neck Cancer....Pages 367-374
Different Platinum Schedules in the Treatment of Epithelial Ovarian Cancer....Pages 375-385
Chemotherapy of Lung Cancer....Pages 386-393
Platinum, the Synergistic Drug: From Clinical Evidence to Laboratory Suggestions....Pages 394-414
Chemotherapy of Mammary Cancer with Anthracyclins and Alkylators....Pages 415-435
The Pharmaceutical Stabilization of the Clinical Anticancer Drug DACH-Platinum-TMA (NSC271674)....Pages 436-449
A Clinical Study of Reduced Glutathione as a Protective Agent Against Cisplatin-Induced Toxicity....Pages 450-455
Immunity in Patients Treated with Cis -Platinum....Pages 456-459
Early and Progressive Glomerular Kidney Toxicity during Cis -Platinum Therapy....Pages 460-465
Hepatic Arterial Infusion of Cisplatin as a Single Agent or in Combination with Vinblastine for Breast Cancer Metastatic to the Liver....Pages 466-472
Comparison between a Human Small Cell Lung Carcinoma Cell Line (GLC 4 ) and an Adriamycin (GLC 4 -ADR) and a CDDP (GLC 4 -CDDP) Resistant Subline. A Preliminary Report....Pages 473-478
The Effect of Diethyldithiocarbamate (DDTC) on Response, Toxicity and Pharmacology of Cisplatin in Patients with Recurrent Squamous Cell Carcinoma of the Head and Neck....Pages 479-483
Clinical Pharmacokinetics of (R)-(-)-1,1-Cyclobutane-Dicarboxylato-(2-Aminomethylpyrrolidine) Platinum(II) (DWA2114R)....Pages 484-490
Combination of Cisplatin and 5-Fluorouracil in the Treatment of Advanced Breast Cancer....Pages 491-498
Antitumor Effects of High-Dose Cisplatin in Hypertonic Saline Against Human Ovarian Tumors Heterotransplanted in Nude Mice....Pages 499-503
 IP versus IV Pharmacokinetics in Patients Using Radiolabelled Paraplatin....Pages 504-507
Front Matter....Pages 508-516
The Search for New Platinum Antitumor Agents: Progress, Problems and Prospects....Pages 517-517
Front Matter....Pages 519-526
The Anticancer Activity of Metal Phosphine Complexes....Pages 517-517
Platinum-Based Organometallic Complexes of Vitamin C and Related Analogs as Antitumor Agents....Pages 527-537
A Coordination Chemical Approach to Prepare Organ-Specific Antitumor Platinum Complexes in Cancer Chemotherapy....Pages 538-554
Metal-Coordination Chemistry with Biomolecules: Platinum-Nucleobase Interactions....Pages 555-562
Chemical Considerations in the Design of Ruthenium Anticancer Agents....Pages 563-581
Organometallic Titanocene and Ferricenium Complexes: Antitumor and Toxicologic Properties....Pages 582-600
Modelling and Speciation of Metals Involved in Carcinogenesis and its Treatment....Pages 601-611
Metal Complexes of Platinum Group: The Promising Antitumor Features of Cis- Dichlorotetrakis (Dimethylsulfoxide) Ru(II) [ cis - Rucl 2 (Me 2 SO) 4 ] and Related Complexes....Pages 612-616
NMR Study of Properties in Solution of Platinum(II) Ammine-Aqua Complexes, Including Determination of Acid Dissociation Constants....Pages 617-633
Studies on Ruthenium Nitroimidazoles Complexes as Radiosensitizers....Pages 634-637
Platinum(II) Complexes with Alkylamines. Characterization and in Vitro Cytostatic Activity....Pages 638-642
Antitumor Activity of Metal(II) Chelates of 2,2′-Bipyridyl-6-Carbothioamide: in Vitro Study....Pages 643-651
Ternary Complexes of Pt +2 and Pd +2 with Ino, Guo and Amino Acids....Pages 652-656
Synthesis and in Vitro Antineoplastic Activity of Diorganostannylene Derivatives of 2,6-Pyridine Dicarboxylic Acid....Pages 657-661
Two New Water Soluble Platinum Complexes — CL 286, 558 and CL 287, 110....Pages 662-665
Complexes of Water Soluble Polymers and Organoplatinum Compounds as Potential Time-Release Antitumor Formulations....Pages 666-669
Preclinical Development and First Clinical Studies of Budotitane....Pages 670-683
Antitumor Activity of a New Platinum Cytostatic, DWA2114R....Pages 684-694
Bis(Uracil-)-Complexes of Cisplatin: Preparation, Protonation and Metal Binding....Pages 695-699
 Cis -Diphosphine Platinum(II) Complexes with Pyrimydil Nucleosides: Synthesis, Characterization and Structural Studies....Pages 700-704
Front Matter....Pages 705-713
Antitumor Properties of Metal (II) Complexes of 2-Pyridine Carboxaldehyde 2′-Pyridylhydrazones and Related Compounds....Pages 517-517
Metal Ions Complexation Properties of Antitumor Athracyclines. Different Cyto and Cardiotoxicity of Copper(II) Chelates....Pages 714-718
Cytostatic and Antitumour Properties for a New Series of Pt(II) Complexes with Cyclopentylamine....Pages 719-723
1-Methylcytosin-Complexes of Pt(IV)....Pages 724-727
Effects of Nickel-Lapachol in Hypoxic Cells....Pages 728-732
Platinum(II) Complexes with Amides of Pyridinecarbonic Acids and Some Diamides....Pages 733-738
Bidentate Hydroxycarboxylic Acid Platinum(II) Complexes with Antitumor Activity....Pages 739-743
Structure, Magnetic Properties and Antineoplastic Activity of Novel Phthalato-Bridged Copper(II) Complexes....Pages 744-748
Synthesis and Structure of the Tetra 5,6-Dihydropyrimidino[5,4-c] Carbazole Dichloride Hexachloroplatinate (IV) Tetrahydrate....Pages 749-756
Antitumor Activity of Zindoxifene Derived Platinum Complexes....Pages 757-760
Platinum (II) Complexes with Aminopyrimidines....Pages 761-762
Back Matter....Pages 763-767
....Pages 769-775