Platelet-Rich Plasma in Dermatologic Practice

Preface
Contents
Contributors
1: Biology of Platelet-Rich Plasma
	Basics of Platelet Physiology
	Platelet-Rich Plasma (PRP)
		PRP: Background
		Preparation and Composition of PRP
		Growth Factors in PRP
	Mechanisms of Action and Common Uses of PRP in Dermatology
		Skin Rejuvenation
		Treating Scars
		Wound Healing
		Alopecia
	Other Potential Uses
		Summary
	References
2: Platelet-Rich Plasma Preparation Methodologies
	Introduction
	Definition
	Basic Procedural Steps and Nomenclature
	System Types
		Comparative Analytic Studies: In Vitro and In Vivo
	Technical Considerations and Controversies
		Presence of Other Cell Lines: Leukocytes and Erythrocytes
		Addition of Activators
		Selection of Anticoagulant
		Addition of Enhancers and Other Tissue Products
	Conclusion
	References
3: Platelet-Rich Plasma for Skin Rejuvenation
	Skin Age in Layers [1, 4, 11–13, 27, 37, 41]
	PRP: Mechanisms of Skin Layer Regeneration
		Keratinocytes
		Melanocytes [47–75, 79–81]
		Fibroblasts and Elastin Fibers [10, 23, 24, 32, 34]
		Immune Cells [28, 30, 31, 49, 53, 60–63, 76, 77]
	PRP/PRF Preparation (Fig. 3.2)
	PRP: Regenerative Treatment for Skin Aging (Fig. 3.3 – Algorithm for PRP/PRF) [21]
	Contraindications
	Complications [18, 33]
	References
4: Platelet-Rich Plasma for Wound Healing
	Definition of Wound
		Acute Wounds
		Chronic Wounds
	Wound Healing
		Hemostasis and Inflammation
		Epithelialization, Proliferation, and Matrix Synthesis
		Maturation
	Role of PRP in Wound Healing
	Different Types of Wounds
		Ulcers
		Arterial Insufficiency
		Venous Insufficiency
		Mixed Insufficiency
		Neuropathic Ulcer
		Immune Ulcers
		Rare Ulcers
		PRP Therapy for Ulcer Healing
	Burn Care
		PRP Therapy for Burns
	Case Study
	References
5: Platelet-Rich Plasma for Hair Loss
	Introduction
	Role of Inflammation
	Mechanism of Action
	Key Growth Factors and Cytokines
	The Efficacy of PRP as a Treatment for Alopecia
	PRP Techniques
	Conclusions
	References
6: PRP for Scarring and Striae
	Introduction
	PRP for Scars and Striae
	References
7: Platelet-Rich Plasma for Dermal Augmentation of the Face and Body
	Introduction
	Filling Agents: Autologous Fat Grafting, Fillers, and PRP
	Dermal Augmentation of the Face Using PRP
	Vampire Facelift®: Hyaluronic Acid and PRP
	Combination Therapy: Autologous Fat Grafts and PRP
	Dermal Augmentation of the Body: Breast and Buttock
	Dermal Augmentation and Rejuvenation of the Hand
	Conclusion
	References
8: Combination Therapies for PRP
	Introduction
	PRP Combinations with Energy-Based Devices for Acne Scars
	Combination for Skin Rejuvenation
	Combination for Hair Loss
	Future of Combination Treatments Using PRP
	References
9: Controversies in PRP
	Introduction
	Evidence Base for PRP Use
	Lack of Standardization in PRP Preparation (Fig. 9.1)
		Activators
	No Consensus on Injection Protocol
	Media Representations
	Safety of PRP Injection
	Conclusion
	References
Index