Physiology of Membrane Disorders

Front Matter....Pages i-xxv
The Anatomy of Biological Interfaces....Pages 1-26
Dynamics of Lipids in Biomembranes....Pages 27-48
Membrane Proteins: Structure and Arrangement in the Membrane....Pages 49-60
The Nature and Limitations of Electron Microscopic Methods in Biology....Pages 61-93
Isolation and Characterization of Biological Membranes....Pages 95-105
Ultraviolet Absorption, Circular Dichroism, and Optical Rotatory Dispersion in Biomembrane Studies....Pages 107-124
Mathematical Models of Membrane Transport Processes....Pages 125-146
Tracers in the Study of Membrane Processes....Pages 147-164
Principles of Water and Nonelectrolyte Transport across Membranes....Pages 165-184
Principles of Electrical Methods for Studying Membrane Movements of Ions....Pages 185-204
Lipid Bilayer Membranes: Their Permeability Properties as Related to Those of Cell Membranes....Pages 205-216
Ion Selectivity in Membrane Permeation....Pages 217-241
Electrically Neutral Ion Transport in Biomembranes....Pages 243-253
Na and K Transport in Red Blood Cells....Pages 255-272
Ion-Coupled Transport across Biological Membranes....Pages 273-286
The Provision of Cellular Metabolic Energy for Active Ion Transport....Pages 287-314
Regulation of Cellular Volume....Pages 315-334
Cell-to-Cell Communication....Pages 335-356
Genes and Membranes....Pages 357-367
Membrane Immunology and Permeability Functions....Pages 369-398
The Interaction of Hormones with Biological Membranes....Pages 399-416
Modification of Membrane Function by Drugs....Pages 417-445
Processing of Exportable Proteins: Structure-Function Correlates and Role of Cellular Membranes....Pages 447-458
Lactose Transport in Escherichia coli ....Pages 459-478
Some General Properties of Excitable Tissues....Pages 479-491
Ion Movements in Skeletal Muscle in Relation to the Activation of Contraction....Pages 493-515
Excitable Tissues: The Heart....Pages 517-538
Ion and Water Transport in Gastric Mucosa....Pages 539-561
Ion Transport by Gastric Mucosa....Pages 563-576
The Uptake of Lipids into the Intestinal Mucosa....Pages 577-592
The Regulation of Glomerular Filtration Rate in Mammalian Kidneys....Pages 593-627
The Proximal Nephron....Pages 629-660
Transport Characteristics of the Loop of Henle....Pages 661-679
Transport Functions of the Distal Convoluted Tubule....Pages 681-706
The Collecting Duct....Pages 707-737
Renal Hemodynamic Factors and the Regulation of Sodium Excretion....Pages 739-772
Disorders of Ion Transport in Red Blood Cells....Pages 773-800
Inherited Membrane Disorders of Muscle: Duchenne Muscular Dystrophy and Myotonic Muscular Dystrophy....Pages 801-815
Disorders of Muscle Membranes: The Periodic Paralyses....Pages 817-829
The Anatomical Basis for Cardiac Rhythm and Conduction....Pages 831-875
Cholera Toxin, Adenylate Cyclase, and the Process of Active Secretion in the Small Intestine: The Pathogenesis of Diarrhea in Cholera....Pages 877-899
Malabsorption Syndromes....Pages 901-917
Mechanisms of Calcium Absorption: A Reappraisal....Pages 919-940
Cystic Fibrosis....Pages 941-953
Uremia: Strategies in the Search for Toxins....Pages 955-965
Disorders of Glomerular Filtration....Pages 967-985
Cellular Defects in Urinary Acidification and Renal Tubular Acidosis....Pages 987-1017
Cystinosis and the Fanconi Syndrome....Pages 1019-1039
Renal Tubular Defects in Phosphate and Amino Acid Transport....Pages 1041-1061
The Polyuric Syndromes....Pages 1063-1091
Ischemia and Disturbances in Cell Volume Regulation....Pages 1093-1100
Back Matter....Pages 1101-1122