Physiological basis of respiratory disease

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Physiologic Basis of Respiratory Disease......Page 1
Physiologic Basis of Respiratory Disease......Page 3
Copyright......Page 4
Contents......Page 5
Foreword......Page 9
Preface......Page 11
Contributors......Page 13
History of the Meakins-Christie Laboratories......Page 19
Ch01: Histology and Gross Anatomy of the Respiratory Tract......Page 23
Ch02: Statics of the Respiratory System......Page 37
Ch03: Statics of the Lung......Page 49
Ch04: Act of Breathing: Dynamics......Page 57
Ch05: Respiratory Mechanics in Infants and Children......Page 71
Ch06: Physics of Expiratory Flow Limitation......Page 77
Ch07: Act of Breathing: The Ventilatory Pump......Page 83
Ch08: Pulmonary Statics in Disease......Page 91
Ch09: Structure–Function Correlations in Pulmonary Fibrosis......Page 99
Ch10: Structure–Function Relationships in Chronic Obstructive Pulmonary Disease......Page 107
Ch11: Structure–Function Correlations in Asthma......Page 127
Ch12: Structure–Function Relationships in Airway Disease: Analysis by Computed Tomographic Imaging......Page 137
Ch13: Breathing Strategies in Asthma and Chronic Obstructive Lung Disease......Page 145
Ch14: Ventilation Distribution......Page 155
Ch15: Gas Convection and Diffusion......Page 165
Ch16: Lung Vasculature: Functional Inferences from Microstructure......Page 177
Ch17: Ventilation–Perfusion Relationships......Page 187
Ch18: Ventilation-Perfusion Distributions In Disease......Page 207
Ch19: Pulmonary Edema......Page 225
Ch20: Oxygen Regulation of Vasomotor Tone......Page 259
Ch21: Neural Control of Breathing......Page 273
Ch22: Actions of the Respiratory Muscles......Page 285
Ch23: Biology of the Respiratory Muscles......Page 299
Ch24: Respiratory Muscle Fatigue......Page 311
Ch25: Ventilatory Muscle Injury......Page 331
Ch26: Respiratory Consequences of Neuromuscular Disease......Page 341
Ch27: Respiratory Muscles in Sepsis......Page 353
Ch28: Rehabilitation of Skeletal Muscles in Chronic Obstructive Pulmonary Disease......Page 361
Ch29: Genetics of Respiratory Disease......Page 371
Ch30: Neurohumoral Control of the Airways......Page 385
Ch30: Neurohumoral Control of the Airways......Page 393
Ch32: Airway Smooth Muscle: The Contractile Phenotype......Page 403
Ch33: Cytokines and Airway Smooth Muscle......Page 411
Ch34: Immunoglobulins and the Lung......Page 421
Ch35: Mucus and its Role in Airway Clearance and Cytoprotection......Page 431
Ch36: Mucociliary Clearance and Cystic Fibrosis......Page 439
Ch37: Fluid and Electrolyte Transport in the Airways......Page 451
Ch38: Epithelial Function in Lung Injury......Page 461
Ch39: Cytokines and Chemokines in Asthma: An Overview......Page 475
Ch40: Nitric Oxide and the Lung......Page 491
Ch41: Viral Infections and Airway Responsiveness......Page 501
Ch42: Roles of Lipid Mediators in Acute Lung Injury and Pulmonary Fibrosis......Page 511
Ch43: Eicosanoids and the Lung......Page 517
Ch44: Lung Transplantation......Page 531
Ch45: Physiologic Responses to Exercise......Page 547
Ch46: Ventilatory Factors in Exercise Performance in Patients with Chronic Obstructive Pulmonary Disease......Page 563
Ch47: Practical Assessment of Exercise Limitation......Page 569
Ch48: Regulation of Skeletal Blood Flow During Exercise......Page 577
Ch49: Peripheral Muscle Dysfunction in Chronic Obstructive Pulmonary Disease......Page 589
Ch50: Physiology of the Upper Airways and Upper Airway Obstruction in Disease......Page 603
Ch51: Cardiovascular Consequences of Sleep-Disordered Breathing......Page 619
Ch52: Complexity and Respiration: A Matter of Life and Death......Page 627
Ch53: Sex and Gender Differences in Airway Behavior Across the Human Life Span......Page 633
Ch54: Measurement Techniques in Respiratory Mechanics......Page 645
Ch55: Esophageal Pressure Measurement......Page 661
Ch56: Guide to the Evaluation of Pulmonary Function......Page 671
Ch57: Single-Breath Carbon Monoxide Diffusing Capacity or Transfer Factor......Page 681
Ch58: Spirometric Predictions of Exercise Limitation in Patients with Chronic Obstructive Pulmonary Disease......Page 693
Ch59: Determinants of Decline in Lung Function......Page 703
Ch60: Assessment of Respiratory Muscles......Page 711
Ch61: Assessment of Acid–Base Balance: A Physical-Chemical Approach......Page 721
Ch62: Airway Hyperresponsiveness......Page 731
Ch63: Assessment of Forced Expiratory Flows in Infants......Page 743
Ch64: Evaluation of the Patient with Occupational Asthma......Page 749
Ch65: Physiologic Basis for Pulmonary Rehabilitation of Chronic Obstructive Pulmonary Disease......Page 755
Ch66: Lung Volume Reduction Surgery......Page 767
Ch67: Diaphragm Responses to Stimulation......Page 777
Ch68: An Introduction to Lung Morphometry......Page 791
Index......Page 799