Photobiology: The Science and Its Applications

Front Matter....Pages i-xviii
Opening of the Congress....Pages 1-2
Themes and Trends in Photobiology....Pages 3-11
Front Matter....Pages 13-13
Alexander Hollaender (1898-1986)....Pages 15-16
Alexander Hollaender: The Man and His Work*....Pages 17-20
Defective DNA Repair and Human Disease....Pages 21-26
DNA-Protein Crosslinking in UV-Irradiated Human and ICR 2A Cell Lines....Pages 27-34
Retroviral Based Shuttle Vectors and Endogenous Cellular Genes: Complementary Approaches for Investigations of Mutational Specificity....Pages 35-40
Front Matter....Pages 41-41
Photobiology and Radiobiology: Divisions and Common Ground....Pages 43-48
Comparative Effects of Ultraviolet and Ionizing Radiations on Nucleic Acids....Pages 49-59
Interaction Between Ultraviolet and Ionizing Radiation in Eukaryotic Cells....Pages 61-69
A Molecular Model for the Cytotoxic Action of UV and Ionizing Radiation....Pages 71-81
Mutagenic Effects of Ultraviolet and Ionizing Radiation....Pages 83-95
Malignant Transformation by Ultraviolet and Ionizing Radiations....Pages 97-103
Between Ultraviolet and Ionizing Radiation: Action Spectra for Cytotoxicity in the Vacuum-UV Region....Pages 105-111
Front Matter....Pages 113-113
Brief Methodological Survey of the Photochemistry of Nucleic Acid Constituents and Analogues, and Some Biological Applications, Including Photo-Affinity Labeling....Pages 115-133
The Sequence Specificity of Ultraviolet Light Damage to DNA Containing Bromodeoxyuridine or Iododeoxyuridine....Pages 135-140
UV-Light Induced Perturbation of DNA Tertiary Structure: Consequences on the Enzymes Controlling Chromosome Superhelicity....Pages 141-147
Excision-Repair Capacity in UV Irradiated Strains of S. pneumoniae ....Pages 149-154
UV-Inducible Repair in Yeast....Pages 155-162
Mutant I12X86 Versus Wild-Type Lac Repressor Photochemistry....Pages 163-168
Front Matter....Pages 113-113
 umuC -Independent, recA -Dependent Mutagenesis....Pages 169-176
What is the Molecular Mechanism of UV Mutagenesis in Escherichia coli ?....Pages 177-182
Ultraviolet Mutagenesis of a Shuttle Vector Plasmid in Repair Proficient and Deficient Human Cells....Pages 183-192
Mutational Hotspots in Mammalian Cells....Pages 193-198
Spectra of Mutations Induced by Structurally-Related Aromatic Polycyclic Carcinogens during Replication of a Shuttle Vector in Human Cells....Pages 199-210
Twenty Years of Research on Xeroderma Pigmentosum at the National Institutes of Health....Pages 211-221
Repair Control of Photoinduced Cross-Links and Monoadducts in DNA: Genetic, Molecular and Evolutionary Features....Pages 223-233
Front Matter....Pages 235-235
Pulse Radiolysis and Flash Photolysis....Pages 237-247
Discrimination and Coverage in Hybridization: Advantages Afforded by Crosslinkable Oligonucleotide Probes....Pages 249-266
The Analytical Uses of Luminescence....Pages 267-276
Electric Parameters of Purple Membrane Fragments....Pages 277-286
Probing the Internal Spectral Distribution of UV Radiation in Plants with Fibre Optics....Pages 287-292
Cancer Diagnosis by Fluorescence Polarization....Pages 293-303
Microspectrofluorometry of Human Melanoma Cells and Fibroblasts Treated with Azelaic Acid....Pages 305-318
Recent Advances in Chemical Modeling of Bacterial Bioluminescence Mechanism....Pages 319-328
Use of Image Analysis in Photobiology....Pages 329-343
Degradation of Oligonucleotides and DNA by VUV Radiation in Solids....Pages 345-353
Photolysis of Water by VUV Radiation and Reactions with DNA and Related Compounds in Aqueous Systems....Pages 355-363
Front Matter....Pages 365-365
Trapping of Excitation Energy in Photosynthetic Purple Bacteria....Pages 367-378
The Supramolecular Structure of the Light-Harvesting System of Cyanobacteria and Red Algae....Pages 379-389
Front Matter....Pages 365-365
Quinone Substituted Porphyrin Dimers: New Photosynthetic Model Systems....Pages 391-399
Organization of the Photosynthetic Membrane of Rhodopseudomonas Viridis Using Biochemical, Immunological and Electron Microscopical Methods....Pages 401-408
Front Matter....Pages 409-409
The Chromophore and its Role in the Phototransformation of Phytochrome: Conformational Changes Probed with bis-ANS, Monoclonal Antibodies and Phosphorylation....Pages 411-422
Molecular Properties of Phytochrome....Pages 423-434
Studies of the Mechanism of the Phototransformation of Phytochrome....Pages 435-436
The Significance of Mutants in Phytochrome Research....Pages 437-443
Mode of Coaction between Phytochrome and Blue/UV Photoreceptors....Pages 445-453
Phytochrome Regulated Expression of Cab Genes in Higher Plants....Pages 455-460
Phytochrome Structure/Function Relationships as Probed by Monoclonal Antibodies....Pages 461-468
Phytochrome from Green Avena Characterized with Monoclonal Antibodies Directed to It....Pages 469-477
Phytochrome and Cryptochrome: Coaction or Interaction in the Control of Chloroplast Orientation....Pages 479-489
Photochemistry and Photophysics of Biliprotein Chromophores: A Case of Molecular Ecology....Pages 491-495
Strategy of Orientation in Flagellates....Pages 497-510
Polarized Spectra of Immobilized Phycobilisomes Isolated from Various Cyanobacteria....Pages 511-517
Front Matter....Pages 519-519
Spectra and Structures of Photorhodopsin and Bathorhodopsin Studied by Picosecond Laser Photolysis....Pages 521-530
The Primary Photochemical Process in Bacteriorhodopsin....Pages 531-535
Functional Domains in Octopus Rhodopsin....Pages 537-546
Picosecond Time-resolved Spectroscopy of the Initial Events in the Bacteriorhodopsin Photocycle....Pages 547-559
Primary Processes in Sensory Rhodopsin and Retinochrome....Pages 561-570
Front Matter....Pages 571-571
Seasonal Changes in Circadian Rhythm of Thermoregulation in Greenfinches and Siskins at Different Ambient Temperatures....Pages 573-579
Front Matter....Pages 571-571
Light and Circadian Activity in the Blind Mole Rat....Pages 581-589
Photoperiod Changes and Heat Production in Meriones Crassus — The Role of Circadian Rhythms of Body Temperature in Seasonal Acclimatization....Pages 591-596
Physiological Responses of Melatonin-Implanted Pigeons to Changes in Ambient Temperature....Pages 597-605
Melatonin Binding Sites in Discrete Brain Areas: Coincidence with Physiological Responsiveness....Pages 607-612
Front Matter....Pages 613-613
Signal Transduction in Blue Light-Mediated Growth Responses....Pages 615-623
Potential Impacts of Increased Solar UV-B on Global Plant Productivity....Pages 625-634
Effects of Enhanced Solar UV-B Radiation on Growth and Function of Selected Crop Plant Seedlings....Pages 635-649
Front Matter....Pages 651-651
Sources of Human Exposure to Ultraviolet Radiation....Pages 653-661
Drug Products and Photocarcinogenesis....Pages 663-669
Investigating Contact Photoallergy in the Mouse....Pages 671-682
Relation Between the Molecular Structure of a Drug and its Photobiological Activity by Combination of In vivo and In vitro Research....Pages 683-691
Screening Materials for Photosensitization Eye Effects....Pages 693-701
Front Matter....Pages 703-703
Solar Ultraviolet Radiation and Skin Cancer in Man....Pages 705-714
Presentation of the Finsen Medal to D.I. Arnon....Pages 715-716
Presentation of the Finsen Medal to I.A. Magnus....Pages 717-717
 Monodelphis domestica : An Animal Model for Studies in Photodermatology Including the Induction of Melanoma....Pages 719-722
Prolonged UVR-Induced Erythema and Melanoma Risk Factors....Pages 723-726
Ultraviolet Radiation Induces Cytoskeletal Damage in Human Cells....Pages 727-732
Front Matter....Pages 733-733
Overview: Photoimmunology....Pages 735-741
Immunology of UV-Induced Human Skin Cancer....Pages 743-748
Front Matter....Pages 733-733
Immunological Mediators Produced by UV-Irradiated Keratinocytes....Pages 749-757
Front Matter....Pages 759-759
Franz Greiter — The Man and His Work....Pages 761-761
Immune Suppression by Ultraviolet B Irradiation and Urocanic Acid....Pages 763-768
Effects of Radiant Energy on the Ocular Tissues....Pages 769-785
On the Effect of Ultraviolet Radiation on the Eye....Pages 787-791
Front Matter....Pages 793-793
Model System Studies on Photosensitization in Light Scattering Media....Pages 795-806
 In Vitro and In Vivo Spectral Properties of Porphyrins....Pages 807-813
Photosensitization of Microbial Cells....Pages 815-820
Effects of PDT on DNA and Chromosomes....Pages 821-829
Photophysical and Photosensitizing Properties of Phthalocyanines....Pages 831-837
Zinc(II)-Phthalocyanine as a Second-Generation Photosensitizing Agent in Tumour Phototherapy....Pages 839-845
Photosensitization by Phthalocyanines. Chemical Structure — Photodynamic Activity Relationship....Pages 847-851
Front Matter....Pages 853-853
Cellular Effects of UVA: DNA Damages....Pages 855-859
Cellular Defense Against UVA (320–380 nm) and UVB (290–320 nm) Radiations....Pages 861-871
Melanin is a Double-Edged Sword....Pages 873-886
Sun Protection Factors....Pages 889-896
The Reliability of Sun Protection Factor....Pages 897-899
Sunscreens - A Photochemical Perspective....Pages 901-902
The Protective Ability of Sunscreens....Pages 903-908
The Broad Spectrum Concept in Sunscreens....Pages 909-916
Front Matter....Pages 853-853
Trends in Sun Protection....Pages 917-922
Front Matter....Pages 923-923
Photochemoprotection: Protective Effects of Psoralen-Induced Tan....Pages 925-932
Mutagenic Effects of Psoralen-Induced Photoadducts and their Repair in Eukaryotic Cells....Pages 933-950
Quantification of 8-MOP Photoadducts in Lymphocytes....Pages 951-962
New Aspects of the Mechanism of Action of Furocoumarins (Psoralens and Angelicins)....Pages 963-973
Photodynamic Carcinogenicity and its Prevention by Carotenoids as Oxygen Radical Quenchers: Relevance in Animals and Human Intervention....Pages 975-1007
Front Matter....Pages 1009-1009
UV and the Environment: An Introduction....Pages 1011-1014
UV and Exobiology: Can Micro-Organisms Survive the Space Environment....Pages 1015-1022
Further Solar UV Spectral Measurements at the Dead Sea....Pages 1023-1026
Ozone and Ultraviolet Light are Additive Co-Carcinogens In Vitro ....Pages 1027-1030
Front Matter....Pages 1031-1031
Skin Photobiology and Regulations on UV Radiation....Pages 1033-1035
Patterns of Human Exposure to Ultraviolet Radiation....Pages 1037-1044
Cutaneous Photosensitization: Hazard and Regulation....Pages 1045-1055
UV Regulatory Strategies....Pages 1057-1068
Round Table: Photobiology in Developing Countries....Pages 1069-1072
Back Matter....Pages 1073-1083