Phospholipid Research and the Nervous System: Biochemical and Molecular Pharmacology

Front Matter....Pages I-XIII
Polyphosphoinositide Breakdown without Calcium Mobilization: Studies with Adrenal Chromaffin Cells and Retina....Pages 1-8
Inositol Lipid Metabolism in Receptor-Stimulated and Depolarized Sympathetic Ganglia and Adrenal Glands....Pages 9-18
Second Messenger Generation and Secretion in PC12 Cells. Role of Ca ++ and Phosphoinositide Hydrolysis....Pages 19-29
Phosphoprotein B-50 and Polyphosphoinositide-Dependent Signal Transduction in Brain....Pages 31-41
Possible Roles of Inositol Phospholipids in Cell Surface Signal Transduction in Neuronal Tissues....Pages 43-48
Possible Glial Modulation of Neuronal Activity by Eicosanoids and Phosphoinositide Metabolites....Pages 49-55
Drugs Affecting Membrane Lipid Catabolism: The Brain Free Fatty Acid Effect....Pages 57-66
Unique Metabolic Features of Docosahexaenoate Metabolism Related to Functional Roles in Brain and Retina....Pages 67-78
Pharmacological Agents and the Release of Arachidonic Acid and Prostaglandin Biosynthesis by Rabbit Iris Muscle....Pages 79-91
Phospholipid Metabolism in Nervous Tissues: Modification of Precursor Incorporation and Enzyme Activities by Cationic Amphiphilic Drugs....Pages 93-111
Phospholipid-Protein Kinase C Involvement in the Adrenergic Regulation of Pinealocyte Cyclic AMP: A Model of How Modulators Act?....Pages 113-120
The Effects of Ethanol on Receptor Activated Phospholipid Cascades....Pages 121-132
Effects of Ethanol on Brain Phospholipids....Pages 133-146
Effects of Ethanol on Concentration and Acyl Group Composition of Acidic Phospholipids....Pages 147-159
The Control and Function of Inositide-Metabolizing Enzymes....Pages 161-167
Diacylglycerols and Arachidonic Acid in the Molecular Pathogenesis of Brain Injury....Pages 169-180
Membrane Bound Diacylglycerol Lipases in Bovine Brain: Purification and Characterization....Pages 181-190
Roles of Lipases in the Development of Autonomic Neurons....Pages 191-197
Phospholipids and Membrane Phenomena Involved in the Release of Mediators of Anaphylaxis....Pages 199-206
Role of Lipids During Fusion of Model and Biological Membranes....Pages 207-216
Serine Phospholipids in Cell Communication....Pages 217-223
Phospholipid Metabolism in Aging Brain....Pages 225-231
Pharmacological Properties of Phosphatidylserine in the Aging Brain: Biochemical Aspects and Therapeutic Potential....Pages 233-241
Essential Fatty Acids and Phospholipids as Drugs in the Treatment of Alcoholism....Pages 243-250
Axonally Transported Phospholipids and Neurite Regrowth....Pages 251-264
Effect of Phosphatidylserine on Cortical Acetylcholine Release and Calcium Uptake in Adult and Aging Rats....Pages 265-271
Synthesis De Novo of Choline, Production of Choline from Phospholipids, and Effects of CDP-Choline on Nerve Cell Survival....Pages 273-281
Relationships between Acetylcholine Release and Membrane Phosphatidylcholine Turnover in Brain and in Cultured Cholinergic Neurons....Pages 283-290
Back Matter....Pages 291-302