Phosphate Metabolism

Front Matter....Pages i-xiii
Front Matter....Pages 1-1
Renal Handling of Phosphate: Update....Pages 3-14
Renal Handling of Calcium: Overview....Pages 15-27
Renal Tubular Effects of Vitamin D and Its Metabolites....Pages 29-40
Phylogeny of Renal Phosphate Transport in the Vertebrates....Pages 41-53
Transepithelial Transport of Phosphate Anion in Kidney. Potential Mechanisms for Hypophosphatemia....Pages 55-70
Renal Adenylate Cyclase, Calcitonin Receptors and Phosphate Excretion in Rats Immunized Against Tubular Basement Membranes....Pages 71-73
Renal Tubular Handling of 3′,5′ — cAMP in Normal and Parathyroidectomized Rats....Pages 75-76
Effects of Glucose on Intestinal and Renal Handling of Calcium....Pages 77-84
Renal Actions of 25-Hydroxyvitamin D 3 ....Pages 85-93
Hypercalciuria after Diphenylhydantoin....Pages 95-100
Renal Phosphate Transport in the Phosphate-Depleted Dogs....Pages 101-103
Dissociated Reabsorption of Phosphate and Bicarbonate in the Post-Obstructed Dog Kidney....Pages 105-113
Parathyroid Hormone-Induced Inhibition of Bicarbonate-Dependent Fluid Absorption in the Proximal Renal Tubule of the Rabbit....Pages 115-120
Renal Handling of Sodium, Water and Divalent Ions in Patients with Primary Biliary Cirrhosis....Pages 121-129
Minor Influence of Parathyroid Hormone on Fractional Tubular Reabsorption of Phosphate in Chronic Renal Failure....Pages 131-139
The Maximal Tubular Reabsorption of Phosphate in Relation to Serum Parathyroid Hormone....Pages 141-148
The Postproximal Site of Phosphate Reabsorption in Presence and Absence of Parathyroid Hormone....Pages 149-151
Saturation Kinetics of Phosphate Reabsorption in Rats....Pages 153-155
Hypocalciuric Effect of Lithium in Man....Pages 157-172
The Renal Handling of Phosphate by Renal Transplant Patients: Correlation with Serum Parathyroid Hormone (S PTH ), Cyclic 3′,5′-Adenosine Monophosphate (cAMP) Urinary Excretion, and Allograft Function....Pages 173-181
Front Matter....Pages 1-1
Independence of Phosphate Homeostasis From Parathyroid Function in the Phosphate-Depleted Rat....Pages 183-192
Front Matter....Pages 193-193
Regulation of Vitamin D Metabolism in the Kidney....Pages 195-209
Interrelationships Between the Key Elements of the Vitamin D Endocrine System: 25-OH-D 3 -1-Hydroxylase, Serum Calcium and Phosphorus Levels, Intestinal 1,25(OH) 2 D 3 , and Intestinal Calcium Binding Protein....Pages 211-231
Influence of Phosphate Depletion on the Biosynthesis and Circulating Level of 1α,25-Dihydroxyvitamin D....Pages 233-250
The Regulation of Vitamin D Metabolism....Pages 251-261
Front Matter....Pages 263-263
Phosphate Transport by Isolated Renal and Intestinal Plasma Membranes....Pages 265-277
Diphosphonates Mode of Action and Clinical Applications....Pages 279-289
Mechanism of Renal Action of Parathyroid Hormone....Pages 291-299
Metabolic Acidosis in Hyperparathyroidism Role of Phosphate Depletion and Other Factors....Pages 301-307
Idiopathic Hypercalciuria....Pages 309-317
Is There a Bone-Kidney Link in the Homeostasis of Inorganic Phosphate (Pi)?....Pages 319-322
Effect of Vitamin D 3 and 1,25-Dihydroxyvitamin D 3 on Intestinal Transport of Phosphate....Pages 323-332
Sodium-Dependent Transport of Orthophosphate in Nerve Fibres....Pages 333-344
Occurrence of Hyperparathyroidism in Children with X-Linked Hypophosphatemia under Treatment with Vitamin D and Phosphate....Pages 345-351
A Possible Relationship Between High-Extraction Cereal and Rickets and Osteomalacia....Pages 353-362
Inhibition of Parathyroid Hormone Secretion by Isoproterenol....Pages 363-368
Effect of Parathyroid Hormone and Volume Expansion on Jejunal Calcium, Sodium, and Water Transport in the Rat....Pages 369-377
Cholecalciferol Metabolites Binding in Porcine Parathyroid Glands....Pages 379-384
Effect of a Ca 2+ dependent protein kinase and a protein phosphatase on the Ca 2+ -phosphate transport ATPase....Pages 385-394
Influence of Vitamin D on Bicarbonate Reabsorption....Pages 395-404
Front Matter....Pages 263-263
Partial Body Phosphorus by Neutron Activation Analysis and Its Clinical Application....Pages 405-413
The Intestinal Absorption of Phosphate in Normal Human Subjects....Pages 415-421
Effect of the Diphosphonate EHDP on Plasma Inorganic Phosphate and Hemoglobin Oxygen Affinity of Diabetic and Healthy Subjects....Pages 423-430
The Action of 1αhydroxy Vitamin D 3 and Phosphate Supplements in Hypophosphataemic Osteomalacia....Pages 431-440
25-Hydroxycholecalciferol: High Affinity Substrate for Hepatic Cytochrome P-450....Pages 441-453
Renal Function in Treated Hypoparathyroidism a Possible Direct Nephrotoxic Effect of Vitamin D....Pages 455-464
Front Matter....Pages 465-465
The Role of Phosphate and Other Factors on the Pathogenesis of Renal Osteodystrophy....Pages 467-475
Ultrastructural Aspects of Bone Mineralization in Renal Osteodystrophy....Pages 477-491
Renal Osteodystrophy Studies with Scanning and Transmission Electron Microscopy....Pages 493-505
Controversies Regarding Intestinal Phosphate Transport and Absorption....Pages 507-513
Skeletal Growth in Uremia....Pages 515-531
The Management of Renal Osteodystrophy....Pages 533-547
Intestinal Phosphate Absorption in Normal and Uremic Man: Effects of 1,25(OH) 2 -Vitamin D 3 and 1α(OH)-Vitamin D 3 ....Pages 549-557
The Effect of Plasma Phosphate on the Action of 1αOHD 3 in Haemodialysis Patients....Pages 559-569
Evidence for a Relationship between Plasma Immunoreactive Calcitonin and Bone Disease in chronic Renal Failure....Pages 571-579
Hypophosphataemia and Osteomalacia in Haemodialysis Patients Not Taking Phosphate Binders....Pages 581-590
Effects of 25-Hydroxycholecalciferol on Calcium Metabolism in Chronic Renal Failure....Pages 591-601
Bone Disease, Hypophosphatemia and Hyperparathyroidism After Renal Transplantation....Pages 603-610
Scintigraphic Skeletal Changes in Dialysis and Kidney Transplanted Patients....Pages 611-619
Back Matter....Pages 621-636