Pharmacological Sciences: Perspectives for Research and Therapy in the Late 1990s

Front Matter....Pages I-XXI
Front Matter....Pages 1-1
Molecular Studies of Glutamate Receptors....Pages 3-9
GABA Receptor Pharmacology....Pages 11-16
Serotonin Receptor Subtypes: Exploiting their Therapeutic Potential....Pages 17-27
Peptide Receptor Antagonists....Pages 29-36
Angiotensin Receptor Subtypes and their Pharmacology....Pages 37-58
Foundations and Future of Molecular Pharmacology....Pages 59-63
Front Matter....Pages 65-65
Lipid Messengers and Protein Kinase C for Intracellular Signalling....Pages 67-72
Mechanisms for the Regulation of Inositol Lipid Signaling and Calcium Homeostasis....Pages 73-79
G-Protein-Linked Receptors and Tyrosine Kinase-Mediated Signal Transduction Pathways: A Mid-1990s Perspective, with Working Hypotheses....Pages 81-89
Receptor-G Protein-Effector Coupling: Coding and Regulation of the Signal Transduction Process....Pages 91-103
Front Matter....Pages 105-105
Novel Aspects of the Pharmacology of Calcium Channel Modulators....Pages 107-115
Calcium Channels, Calcium Channel Antagonists and the Functioning of the Gastrointestinal Tract....Pages 117-127
Aspects of Potassium Channel Modulation....Pages 129-141
Front Matter....Pages 143-143
The Proliferating P450s: Providers of Polysubstrate Pharmacology....Pages 145-151
Human Cytochromes P450: Regulation and Functional Variability....Pages 153-159
Drug Conjugation: Diversity and Biological Significance....Pages 161-168
Interethnic Differences in Drug Metabolism and Pharmacogenetics....Pages 169-175
Dietary Effects on Drug Metabolism....Pages 177-185
Front Matter....Pages 187-187
Neurotransmitter Functions of Mammalian Tachykinins: Substance P and Neurokinin A....Pages 189-197
Molecular Events Underlying the Anti-Opioid Effect of Cholecystokinin Octapeptide (CCK-8) in the Central Nervous System....Pages 199-207
Front Matter....Pages 187-187
Pharmacology of Excitatory Amino Acid Receptors....Pages 209-218
GABA Receptors: Recent Advances....Pages 219-229
Therapeutic Possibilities with Serotonergic Drugs....Pages 231-240
The Pharmacology of Neurotrophic Factors....Pages 241-254
New Perspectives in the Pharmacology of Parenchimal Brain Anoxia-Ischemia....Pages 255-264
Pathophysiology and Future Pharmacotherapy of Chronic Pain....Pages 265-271
Neurohormonal Systems Underlying Drug Addiction: Relevance for Treatment Strategies....Pages 273-279
Molecular and Cellular Mechanisms in Neurosecretion....Pages 281-292
Front Matter....Pages 293-293
Role of Purines in the Central Nervous System....Pages 295-302
Adenosine: Some Therapeutic Applications and Prospects....Pages 303-309
Front Matter....Pages 311-311
Endothelins: Recent Progress....Pages 313-318
Drugs Directly Affecting The Arterial Wall....Pages 319-325
Chronic Drug Treatment of Essential Hypertension....Pages 327-333
Role of Potassium Channel Blockers in the Treatment of Cardiac Arrhythmias....Pages 335-344
Front Matter....Pages 345-345
Nitric Oxide in the Cardiovascular System....Pages 347-353
Role of the L-Arginine-NO-Cyclic GMP Pathway in NANC Neurotransmission....Pages 355-362
Front Matter....Pages 363-363
Neuroendocrine Hormones and the Immune System....Pages 365-372
Selected Aspects of the Immunopharmacology of Cytokines....Pages 373-380
Targeted Therapy of Cancer and Autoimmune Diseases....Pages 381-389
Front Matter....Pages 391-391
Antisense Therapeutics....Pages 393-399
Front Matter....Pages 401-401
Molecular Mechanisms of Anti-Asthma Therapy....Pages 403-409
Front Matter....Pages 411-411
Membrane Transport of Anticancer Drugs and Drug Resistance....Pages 413-431
Front Matter....Pages 433-433
Importance of Individual Enzymes in the Control of Ultimate Carcinogens....Pages 435-439
Molecular and Cellular Aspects of Chemical Carcinogenesis....Pages 441-446
Alterations in Cell Signaling and Cytotoxicity....Pages 447-452
Calcium-Dependent Mechanisms in Drug Toxicity and Cell Killing....Pages 453-460
Liver Toxicity Mediated by Leukocytes and Kupffer Cells....Pages 461-468
Front Matter....Pages 469-469
Harmonization of Drug Regulation and Trial Requirements: Clinical Pharmacological Aspects and Responsibilities....Pages 471-477
Front Matter....Pages 479-479
 In Vivo Magnetic Resonance in Pharmacological Research....Pages 481-491
Application of Cell Culture Systems to the Study of Drug Transport and Metabolism....Pages 493-501
Front Matter....Pages 503-503
Providing Quality Education in Pharmacology: The Affordable Options....Pages 505-511
Back Matter....Pages 513-519