Pharmacokinetics of Drugs

Front Matter....Pages I-XXVI
Front Matter....Pages 1-1
Role of Pharmacokinetics in Drug Discovery and Development....Pages 3-19
Front Matter....Pages 21-21
Contemporary Aspects of Radioimmunoassay Development for Drug Analysis....Pages 23-39
Mass Spectrometry in Drug Disposition and Pharmacokinetics....Pages 41-84
Analytical Methods for Biotechnology Products....Pages 85-98
Front Matter....Pages 99-99
Metabolism: Scaling-up from In Vitro to Organ and Whole Body....Pages 101-187
Gastrointestinal Transport of Peptide and Protein Drugs and Prodrugs....Pages 189-206
Front Matter....Pages 207-207
Stereoselectivity in Metabolic Reactions of Toxication and Detoxication....Pages 209-231
Interethnic Differences in Drug Disposition and Response: Relevance for Drug Development, Licensing, and Registration....Pages 233-263
Clinical Relevance of Pharmacogenetics....Pages 265-288
Role of Environmental Factors in the Pharmacokinetics of Drugs: Considerations with Respect to Animal Models, P-450 Enzymes, and Probe Drugs....Pages 289-332
Time Course of Drug Effect....Pages 333-352
Front Matter....Pages 353-353
Biotechnology Products....Pages 355-370
Peptide and Protein Drugs....Pages 371-382
Toxicokinetics....Pages 383-403
The Population Approach: Rationale, Methods, and Applications in Clinical Pharmacology and Drug Development....Pages 405-451
Front Matter....Pages 453-453
Contribution of Positron Emission Tomography to Pharmacokinetic Studies....Pages 455-480
In Vivo Imaging in Drug Discovery and Design....Pages 481-503
Front Matter....Pages 505-505
Considerations on Data Analysis Using Computer Methods and Currently Available Software for Personal Computers....Pages 507-527
Back Matter....Pages 529-537