Pharmacokinetics in Drug Development: Advances and Applications, Volume 3

Front Matter....Pages i-xii
Modeling Tumor Growth in Oncology....Pages 1-19
Drug–Drug Interactions: Designing Development Programs and Appropriate Product Labeling....Pages 21-56
Modeling the Progression of Disease....Pages 57-90
The Use of Dried Blood Spots for Concentration Assessment in Pharmacokinetic Evaluations....Pages 91-114
Microdosing: Pharmacokinetic and Metabolism Data Early in the Drug Development Process....Pages 115-130
Metabolite Testing in Drug Development....Pages 131-143
The -Omics in Drug Development....Pages 145-173
Optimal Design of Pharmacokinetic–Pharmacodynamic Studies....Pages 175-193
Pharmacokinetic Studies in Pregnant Women....Pages 195-209
Design, Conduct and Analysis of Thorough QT Studies....Pages 211-241
Contribution of Quantitative Whole-Body Autoradioluminography to the Early Selection and Development of Drug Candidates....Pages 243-259
Pharmacokinetics, Modeling, and Simulation in the Development of Sunitinib Malate: A Case Study....Pages 261-284
The Clinical Significance of Drug Transporters in Drug Disposition and Drug Interactions....Pages 285-313
Erratum to: Modeling Tumor Growth in Oncology....Pages E1-E1
Back Matter....Pages 315-319