Personalized medicine

Content: Front Cover
 Personalized Medicine
 Copyright
 Contents
 Contributors
 Preface
 Chapter One: High-Performance Affinity Chromatography: Applications in Drug-Protein Binding Studies and Personalized Medicine
 1. Introduction
 1.1. Drug-Protein Interactions in Blood
 1.2. Preparation of HPAC Columns for Drug-Protein Binding Studies
 2. Frontal Analysis Studies of Drug-Protein Interactions
 2.1. General Principles of Frontal Analysis
 2.2. Characterization of Simple Interactions by Frontal Analysis
 2.3. Characterization of Complex Interactions by Frontal Analysis 3. Zonal Elution Studies of Drug-Protein Interactions3.1. General Principles of Zonal Elution
 3.2. Characterization of Drug-Protein Interactions by Zonal Elution
 4. Other Methods for Examining Drug-Protein Interactions
 4.1. Peak Decay Method
 4.2. Ultrafast Affinity Extraction
 4.3. Chromatographic Immunoassays
 5. Conclusion
 Acknowledgments
 References
 Chapter Two: Role of Proteomics in the Development of Personalized Medicine
 1. Introduction
 2. Protein Biomarkers
 2.1. Proteomic Technologies for Discovery of Biomarkers
 3. Protein Biochips 3.1. Role of Protein Biochips in Personalized Medicine3.2. Nanoproteomics
 4. Role of Proteomics-Based Molecular Diagnostics in Personalized Medicine
 4.1. Integration of Diagnostics with Therapeutics
 5. Pharmacoproteomics
 5.1. Pharmacoproteomics and Personalized Medicine
 6. Concluding Remarks About Application of Proteomics for Personalized Medicine
 References
 Chapter Three: Metabolomics and Personalized Medicine
 1. Introduction
 2. The Value of ``Omics ́́Technologies in the Development of Personalized Medicine
 3. What is Metabolomics? 3.1. Analytical Methods Most Often Used for Metabolomics3.2. Statistical Approaches
 4. The Application of Metabolomics Toward Personalized Medicine
 4.1. Identification of Disease Biomarkers for Metabolomics-Based Diagnostics
 4.2. Pharmacometabonomics
 4.2.1. Metabolomics and the Elucidation of Drug Mechanisms
 4.2.2. Metabolomics and Understanding Response to Treatment
 4.2.3. Metabolomics and Understanding Drug Toxicology
 5. Concluding Remarks
 Acknowledgments
 References
 Chapter Four: Clinical Perspectives on Targeting Therapies for Personalized Medicine
 1. Introduction 2. What Are Personalized Medicines?3. Rare Diseases
 4. Evidence for Precision Medicines from Real World Data
 5. Using ``Real World ́́Data
 6. Ethical Concerns
 7. Adaptive Trial Design
 8. Companion Diagnostics
 9. Biological Treatments
 10. Case Studies: Targets for Precision Medicines and Companion Diagnostics
 10.1. Drug Transporter Proteins
 10.2. Pleiotropic Effects of Statins
 10.3. Flecainide: Potential Off-Target Mechanism for Sudden Death
 10.4. EGF Receptor 2 Antagonism with Trastuzmab
 10.5. Diagnostic Markers to Guide Selection of Anti-cancer Tyrosine Kinase Receptor Inhibitors